Prostaglandin-endoperoxide synthase 2

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human enzyme involved in inflammation

External resources

ଫ୍ରୀବେସ ସୂଚକ
Microsoft Academic ID
RefSeq protein ID
Encyclopædia Britannica Online ID
science/cyclooxygenase-2

subject named as: cyclooxygenase-2

PDB structure ID
NL CR AUT ID
ph430281

subject named as: cyklooxygenáza 2

Ensembl protein ID
UniProt protein ID

ଦୃଷ୍ଟାନ୍ତ

ଏହା ଯାହାର ଅଂଶ

Prostaglandin G/H synthase 2[୭]
Haem peroxidase domain superfamily, animal type[୭]
Haem peroxidase superfamily[୭]
EGF-like domain, protein family[୮]

found in taxon

Homo sapiens[୬]

encoded by

PTGS2[୬]

molecular function

arachidonate 15-lipoxygenase activity[୯]

determination method: TAS

metal ion binding[୧୦]

determination method: IEA

heme binding[୧୧][୧୨][୧୩]

determination method: ISS, IEA

enzyme binding[୧୪]

determination method: IPI

oxidoreductase activity[୧୦]

determination method: IEA

protein homodimerization activity[୧୩]

determination method: IEA

dioxygenase activity[୧୦]

determination method: IEA

protein binding[୧୫]

determination method: IPI

peroxidase activity[୯][୧୬][୧୭][୧୮]

determination method: IEA, NAS, TAS

prostaglandin-endoperoxide synthase activity[୯][୧୭][୧୮][୧୯][୨୦][୨୧]

determination method: IEA, IDA, TAS

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[୯][୧୯]

determination method: IEA, TAS

peroxidase activity[୨୨][୧୦][୧୨]

determination method: IEA, NAS

prostaglandin-endoperoxide synthase activity[୧୦][୧୨][୧୩][୨୩][୨୪]

determination method: IDA, IEA

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[୧୩]

determination method: IEA

transferase activity[୧୦]

determination method: IEA

cell component

cytoplasm[୧୧][୧୩][୨୫]

determination method: IDA, ISS, IEA

endoplasmic reticulum lumen[୨୬]

determination method: TAS

membrane[୧୦]

determination method: IEA

caveola[୧୩]

determination method: IEA

neuron projection[୧୩][୨୭]

determination method: IDA, IEA

organelle membrane[୧୦]

determination method: IEA

endoplasmic reticulum[୧୦][୨୮][୨୯]

determination method: IDA, IEA

intracellular membrane-bounded organelle[୧୦]

determination method: IEA

endoplasmic reticulum membrane[୩୦][୧୦]

determination method: TAS, IEA

protein-containing complex[୧୩]

determination method: IEA

biological process

response to fructose[୧୩]

determination method: IEA

learning[୧୩]

determination method: IEA

response to organic substance[୧୩]

determination method: IEA

lipoxygenase pathway[୩୦]

determination method: TAS

cellular response to mechanical stimulus[୧୩]

determination method: IEA

response to manganese ion[୧୩]

determination method: IEA

angiogenesis[୧୩]

determination method: IEA

cellular response to hypoxia[୩୧]

determination method: IEP

embryo implantation[୧୩]

determination method: IEA

negative regulation of cell population proliferation[୧୩]

determination method: IEA

response to cytokine[୧୩]

determination method: IEA

negative regulation of smooth muscle contraction[୧୩]

determination method: IEA

memory[୧୩]

determination method: IEA

response to oxidative stress[୧୨]

determination method: IEA

maintenance of blood-brain barrier[୧୩]

determination method: IEA

response to lithium ion[୧୩]

determination method: IEA

response to tumor necrosis factor[୧୩]

determination method: IEA

fatty acid biosynthetic process[୧୦]

determination method: IEA

positive regulation of synaptic transmission, glutamatergic[୧୩]

determination method: IEA

positive regulation of vasoconstriction[୧୩]

determination method: IEA

response to organonitrogen compound[୧୩]

determination method: IEA

inflammatory response[୧୨][୧୩]

determination method: IEA

positive regulation of smooth muscle contraction[୧୩]

determination method: IEA

bone mineralization[୧୩]

determination method: IEA

response to fatty acid[୧୩]

determination method: IEA

response to vitamin D[୧୩]

determination method: IEA

cellular response to UV[୧୩]

determination method: IEA

positive regulation of fever generation[୩୨][୧୩]

determination method: ISS, IEA

cellular response to fluid shear stress[୧୩]

determination method: IEA

positive regulation of synaptic plasticity[୧୩]

determination method: IEA

regulation of blood pressure[୧୧][୧୨][୧୩]

determination method: ISS, IEA

response to lipopolysaccharide[୧୩]

determination method: IEA

positive regulation of platelet-derived growth factor production[୩୨][୧୩]

determination method: ISS, IEA

regulation of inflammatory response[୨୨]

determination method: NAS

brown fat cell differentiation[୧୩]

determination method: IEA

sensory perception of pain[୧୩]

determination method: IEA

response to radiation[୧୩]

determination method: IEA

prostaglandin biosynthetic process[୩୩][୧୧][୧୦][୧୨][୧୩]

determination method: NAS, ISS, IEA

cellular response to ATP[୧୩]

determination method: IEA

ovulation[୧୩]

determination method: IEA

positive regulation of smooth muscle cell proliferation[୧୩]

determination method: IEA

hair cycle[୧୩]

determination method: IEA

response to estradiol[୧୩]

determination method: IEA

positive regulation of cell death[୧୩]

determination method: IEA

positive regulation of cell migration involved in sprouting angiogenesis[୩୪][୧୩]

determination method: ISS, IEA

response to organic cyclic compound[୧୩]

determination method: IEA

lipid metabolism[୧୦]

determination method: IEA

positive regulation of nitric oxide biosynthetic process[୩୪][୧୩]

determination method: ISS, IEA

response to glucocorticoid[୧୩]

determination method: IEA

cyclooxygenase pathway[୩୦][୧୨][୧୩][୨୪]

determination method: IDA, TAS, IEA

fatty acid metabolic process[୧୦]

determination method: IEA

positive regulation of fibroblast growth factor production[୩୪][୧୩]

determination method: ISS, IEA

decidualization[୧୩]

determination method: IEA

regulation of cell population proliferation[୧୩]

determination method: IEA

positive regulation of cell population proliferation[୧୩]

determination method: IEA

negative regulation of calcium ion transport[୧୩]

determination method: IEA

positive regulation of apoptotic process[୧୩]

determination method: IEA

positive regulation of transforming growth factor beta production[୩୪][୧୩]

determination method: ISS, IEA

positive regulation of vascular endothelial growth factor production[୩୪][୧୩]

determination method: ISS, IEA

positive regulation of brown fat cell differentiation[୩୫][୧୩]

determination method: ISS, IEA

negative regulation of synaptic transmission, dopaminergic[୧୩]

determination method: IEA

cellular oxidant detoxification[୩୬]

determination method: IEA

human ageing[୧୩]

determination method: IEA

NAD biosynthesis via nicotinamide riboside salvage pathway[୩୦]

determination method: TAS

cellular response to heat[୧୩]

determination method: IEA

positive regulation of prostaglandin biosynthetic process[୩୩][୧୩]

determination method: IEA, NAS

positive regulation of peptidyl-serine phosphorylation[୧୩]

determination method: IEA

negative regulation of apoptotic process[୧୩]

determination method: IEA

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[୧୩]

determination method: IEA

cellular response to non-ionic osmotic stress[୧୩]

determination method: IEA

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress[୧୩]

determination method: IEA

cellular response to lead ion[୧୩]

determination method: IEA

response to angiotensin[୧୩]

determination method: IEA

prostaglandin metabolic process[୧୦]

determination method: IEA

positive regulation of protein import into nucleus[୧୩]

determination method: IEA

cytokine-mediated signaling pathway[୩୦]

determination method: TAS

long-chain fatty acid biosynthetic process[୩୦]

determination method: TAS

negative regulation of cell cycle[୧୩]

determination method: IEA

regulation of neuroinflammatory response[୧୧][୧୩]

determination method: IEA, ISS

physically interacts with

ଆସ୍ପିରିନ‎‎[୩୭]

ବ୍ୟବହାର: enzyme inhibitor

benzquinamide[୩୮]

ବ୍ୟବହାର: enzyme inhibitor

carprofen[୩୯]

ବ୍ୟବହାର: enzyme inhibitor

ସେଲେକକ୍ସିବ[୪୦]

ବ୍ୟବହାର: enzyme inhibitor

ଡାଇକ୍ଲୋଫେନାକ[୪୧]

ବ୍ୟବହାର: enzyme inhibitor

ଇଟୋଡୋଲାକ[୪୨]

ବ୍ୟବହାର: enzyme inhibitor

etoricoxib[୪୩]

ବ୍ୟବହାର: enzyme inhibitor

ଫ୍ଲର୍ବିପ୍ରୋଫେନ[୪୪]

ବ୍ୟବହାର: enzyme inhibitor

ଆଇବୁପ୍ରୋଫେନ୍[୪୫]

ବ୍ୟବହାର: enzyme inhibitor

କେଟୋପ୍ରୋଫେନ[୪୬]

ବ୍ୟବହାର: enzyme inhibitor

କେଟୋରୋଲାକ[୪୭]

ବ୍ୟବହାର: enzyme inhibitor

lumiracoxib[୪୮]

ବ୍ୟବହାର: enzyme inhibitor

meclofenamic acid[୪୯]

ବ୍ୟବହାର: enzyme inhibitor

ମେଫେନାମିକ୍ ଏସିଡ[୫୦]

ବ୍ୟବହାର: enzyme inhibitor

ମେଲୋକ୍ସିକାମ[୫୧]

ବ୍ୟବହାର: enzyme inhibitor

ନାପ୍ରୋକ୍ସେନ[୫୨]

ବ୍ୟବହାର: enzyme inhibitor

ନିମେସୁଲାଇଡ[୫୩]

ବ୍ୟବହାର: enzyme inhibitor

NS-398[୫୪]

ବ୍ୟବହାର: enzyme inhibitor

ଅକ୍ସାପ୍ରୋଜିନ[୫୫]

ବ୍ୟବହାର: enzyme inhibitor

ପାରାସେଟାମୋଲ[୫୬]

ବ୍ୟବହାର: enzyme inhibitor

phenylbutazone[୫୭]

ବ୍ୟବହାର: enzyme inhibitor

ପିରୋକ୍ସିକାମ[୫୮]

ବ୍ୟବହାର: enzyme inhibitor

resveratrol[୫୯]

ବ୍ୟବହାର: enzyme inhibitor

rofecoxib[୬୦]

ବ୍ୟବହାର: enzyme inhibitor

suprofen[୬୧]

ବ୍ୟବହାର: enzyme inhibitor

valdecoxib[୬୨]

ବ୍ୟବହାର: enzyme inhibitor

ନାପ୍ରୋକ୍ସେନ[୬୩]

object has role: reaction inhibitor

diclofenac sodium[୬୪]

object has role: reaction inhibitor

iguratimod[୬୫]

object has role: reaction inhibitor

ଅକ୍ସାପ୍ରୋଜିନ[୬୬]

object has role: reaction inhibitor

apricoxib[୬୭]

object has role: reaction inhibitor

ଆସ୍ପିରିନ‎‎[୬୮]

object has role: reaction inhibitor

ଆଇବୁପ୍ରୋଫେନ୍[୬୯]

object has role: reaction inhibitor

polmacoxib[୭୦]

object has role: reaction inhibitor

କେଟୋରୋଲାକ[୭୧]

object has role: reaction inhibitor

isoxicam[୭୨]

object has role: reaction inhibitor

ଡାଇକ୍ଲୋଫେନାକ[୭୩]

object has role: reaction inhibitor

ଇଟୋଡୋଲାକ[୭୪]

object has role: reaction inhibitor

ବ୍ରୋମଫେନାକ[୭୫]

object has role: reaction inhibitor

(RS)-fenoprofen[୭୬]

object has role: reaction inhibitor

ଡିଫ୍ଲୁନିସାଲ[୭୭]

object has role: reaction inhibitor

esflurbiprofen[୭୮]

object has role: reaction inhibitor

diclofenac potassium[୭୯]

object has role: reaction inhibitor

(RS)-fenoprofen calcium dihydrate[୮୦]

object has role: reaction inhibitor

ketorolac tromethamine[୮୧]

object has role: reaction inhibitor

naproxen sodium[୮୨]

object has role: reaction inhibitor

tolmetin sodium[୮୩]

object has role: reaction inhibitor

EC enzyme number

1.14.99.1

ଏହାର ଅଂଶ

EGF-like domain[୭]

କମନ୍ସ ଶ୍ରେଣୀ

Cyclooxygenase 2

ଆଧାର

  1. Freebase Data Dumps, ୨୮ ଅକ୍ଟୋବର 2013
  2. NCBI Gene, ୩୦ ମଇ 2020, 5743
  3. ୩.୦ ୩.୧ ୩.୨ ୩.୩ ୩.୪ ୩.୫ P35354, ୯ ଅଗଷ୍ଟ 2016, UniProt, ଇଂରାଜୀ ଭାଷା
  4. Ensembl Release 99, ENSP00000356438
  5. Ensembl Release 99, ENSP00000454130
  6. ୬.୦ ୬.୧ ୬.୨ ୬.୩ UniProt, ୧୩ ନଭେମ୍ବର 2019, P35354
  7. ୭.୦ ୭.୧ ୭.୨ ୭.୩ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P35354
  8. inferred from protein domain or family
  9. ୯.୦ ୯.୧ ୯.୨ ୯.୩ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ୭ ନଭେମ୍ବର 2018, Reactome, GOA
  10. ୧୦.୦୦ ୧୦.୦୧ ୧୦.୦୨ ୧୦.୦୩ ୧୦.୦୪ ୧୦.୦୫ ୧୦.୦୬ ୧୦.୦୭ ୧୦.୦୮ ୧୦.୦୯ ୧୦.୧୦ ୧୦.୧୧ ୧୦.୧୨ ୧୦.୧୩ ୧୦.୧୪ ୧୦.୧୫ IEA, ୯ ମଇ 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  11. ୧୧.୦ ୧୧.୧ ୧୧.୨ ୧୧.୩ ୧୧.୪ ISS, ୯ ମଇ 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  12. ୧୨.୦ ୧୨.୧ ୧୨.୨ ୧୨.୩ ୧୨.୪ ୧୨.୫ ୧୨.୬ ୧୨.୭ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, InterPro, GOA
  13. ୧୩.୦୦ ୧୩.୦୧ ୧୩.୦୨ ୧୩.୦୩ ୧୩.୦୪ ୧୩.୦୫ ୧୩.୦୬ ୧୩.୦୭ ୧୩.୦୮ ୧୩.୦୯ ୧୩.୧୦ ୧୩.୧୧ ୧୩.୧୨ ୧୩.୧୩ ୧୩.୧୪ ୧୩.୧୫ ୧୩.୧୬ ୧୩.୧୭ ୧୩.୧୮ ୧୩.୧୯ ୧୩.୨୦ ୧୩.୨୧ ୧୩.୨୨ ୧୩.୨୩ ୧୩.୨୪ ୧୩.୨୫ ୧୩.୨୬ ୧୩.୨୭ ୧୩.୨୮ ୧୩.୨୯ ୧୩.୩୦ ୧୩.୩୧ ୧୩.୩୨ ୧୩.୩୩ ୧୩.୩୪ ୧୩.୩୫ ୧୩.୩୬ ୧୩.୩୭ ୧୩.୩୮ ୧୩.୩୯ ୧୩.୪୦ ୧୩.୪୧ ୧୩.୪୨ ୧୩.୪୩ ୧୩.୪୪ ୧୩.୪୫ ୧୩.୪୬ ୧୩.୪୭ ୧୩.୪୮ ୧୩.୪୯ ୧୩.୫୦ ୧୩.୫୧ ୧୩.୫୨ ୧୩.୫୩ ୧୩.୫୪ ୧୩.୫୫ ୧୩.୫୬ ୧୩.୫୭ ୧୩.୫୮ ୧୩.୫୯ ୧୩.୬୦ ୧୩.୬୧ ୧୩.୬୨ ୧୩.୬୩ ୧୩.୬୪ ୧୩.୬୫ ୧୩.୬୬ ୧୩.୬୭ ୧୩.୬୮ ୧୩.୬୯ ୧୩.୭୦ ୧୩.୭୧ ୧୩.୭୨ ୧୩.୭୩ ୧୩.୭୪ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Ensembl genome database project, GOA
  14. IPI, ୯ ମଇ 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  15. IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
  16. NAS, ୭ ନଭେମ୍ବର 2018, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
  17. ୧୭.୦ ୧୭.୧ IEA, ୭ ନଭେମ୍ବର 2018, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
  18. ୧୮.୦ ୧୮.୧ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ୭ ନଭେମ୍ବର 2018, InterPro, GOA
  19. ୧୯.୦ ୧୯.୧ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ୭ ନଭେମ୍ବର 2018, Ensembl genome database project, GOA
  20. IDA, ୭ ନଭେମ୍ବର 2018, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
  21. IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ୭ ନଭେମ୍ବର 2018, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
  22. ୨୨.୦ ୨୨.୧ NAS, ୯ ମଇ 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  23. IDA, ୯ ମଇ 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  24. ୨୪.୦ ୨୪.୧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
  25. IDA, ୯ ମଇ 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  26. TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
  27. IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Mouse Genome Informatics, Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina, GOA
  28. IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
  29. IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Human Protein Atlas, GOA
  30. ୩୦.୦ ୩୦.୧ ୩୦.୨ ୩୦.୩ ୩୦.୪ ୩୦.୫ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Reactome, GOA
  31. IEP, ୯ ମଇ 2019, P35354, Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  32. ୩୨.୦ ୩୨.୧ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, GOA
  33. ୩୩.୦ ୩୩.୧ NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
  34. ୩୪.୦ ୩୪.୧ ୩୪.୨ ୩୪.୩ ୩୪.୪ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, Cyclooxygenase regulates angiogenesis induced by colon cancer cells, GOA
  35. ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
  36. IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Gene Ontology Consortium, GOA
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