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Prostaglandin-endoperoxide synthase 2

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human enzyme involved in inflammation

External resources

ଫ୍ରୀବେସ ସୂଚକ
Microsoft Academic ID
RefSeq protein ID
Encyclopædia Britannica Online ID
science/cyclooxygenase-2

subject named as: cyclooxygenase-2

PDB structure ID
NL CR AUT ID
ph430281

subject named as: cyklooxygenáza 2

Ensembl protein ID
UniProt protein ID

ଦୃଷ୍ଟାନ୍ତ

ଏହା ଯାହାର ଅଂଶ

Prostaglandin G/H synthase 2[]
Haem peroxidase domain superfamily, animal type[]
Haem peroxidase superfamily[]
EGF-like domain, protein family[]

found in taxon

Homo sapiens[]

encoded by

PTGS2[]

molecular function

arachidonate 15-lipoxygenase activity[]

determination method or standard: TAS

metal ion binding[୧୦]

determination method or standard: IEA

heme binding[୧୧][୧୨][୧୩]

determination method or standard: ISS, IEA

enzyme binding[୧୪]

determination method or standard: IPI

oxidoreductase activity[୧୦]

determination method or standard: IEA

protein homodimerization activity[୧୩]

determination method or standard: IEA

dioxygenase activity[୧୦]

determination method or standard: IEA

protein binding[୧୫]

determination method or standard: IPI

peroxidase activity[][୧୬][୧୭][୧୮]

determination method or standard: IEA, NAS, TAS

prostaglandin-endoperoxide synthase activity[][୧୭][୧୮][୧୯][୨୦][୨୧]

determination method or standard: IEA, IDA, TAS

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[][୧୯]

determination method or standard: IEA, TAS

peroxidase activity[୨୨][୧୦][୧୨]

determination method or standard: IEA, NAS

prostaglandin-endoperoxide synthase activity[୧୦][୧୨][୧୩][୨୩][୨୪]

determination method or standard: IDA, IEA

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[୧୩]

determination method or standard: IEA

transferase activity[୧୦]

determination method or standard: IEA

cell component

cytoplasm[୧୧][୧୩][୨୫]

determination method or standard: IDA, ISS, IEA

endoplasmic reticulum lumen[୨୬]

determination method or standard: TAS

membrane[୧୦]

determination method or standard: IEA

caveola[୧୩]

determination method or standard: IEA

neuron projection[୧୩][୨୭]

determination method or standard: IDA, IEA

organelle membrane[୧୦]

determination method or standard: IEA

endoplasmic reticulum[୧୦][୨୮][୨୯]

determination method or standard: IDA, IEA

intracellular membrane-bounded organelle[୧୦]

determination method or standard: IEA

endoplasmic reticulum membrane[୩୦][୧୦]

determination method or standard: TAS, IEA

protein-containing complex[୧୩]

determination method or standard: IEA

biological process

response to fructose[୧୩]

determination method or standard: IEA

learning[୧୩]

determination method or standard: IEA

response to organic substance[୧୩]

determination method or standard: IEA

lipoxygenase pathway[୩୦]

determination method or standard: TAS

cellular response to mechanical stimulus[୧୩]

determination method or standard: IEA

response to manganese ion[୧୩]

determination method or standard: IEA

angiogenesis[୧୩]

determination method or standard: IEA

cellular response to hypoxia[୩୧]

determination method or standard: IEP

embryo implantation[୧୩]

determination method or standard: IEA

negative regulation of cell population proliferation[୧୩]

determination method or standard: IEA

response to cytokine[୧୩]

determination method or standard: IEA

negative regulation of smooth muscle contraction[୧୩]

determination method or standard: IEA

memory[୧୩]

determination method or standard: IEA

response to oxidative stress[୧୨]

determination method or standard: IEA

maintenance of blood-brain barrier[୧୩]

determination method or standard: IEA

response to lithium ion[୧୩]

determination method or standard: IEA

response to tumor necrosis factor[୧୩]

determination method or standard: IEA

fatty acid biosynthetic process[୧୦]

determination method or standard: IEA

positive regulation of synaptic transmission, glutamatergic[୧୩]

determination method or standard: IEA

positive regulation of vasoconstriction[୧୩]

determination method or standard: IEA

response to organonitrogen compound[୧୩]

determination method or standard: IEA

inflammatory response[୧୨][୧୩]

determination method or standard: IEA

positive regulation of smooth muscle contraction[୧୩]

determination method or standard: IEA

bone mineralization[୧୩]

determination method or standard: IEA

response to fatty acid[୧୩]

determination method or standard: IEA

response to vitamin D[୧୩]

determination method or standard: IEA

cellular response to UV[୧୩]

determination method or standard: IEA

positive regulation of fever generation[୩୨][୧୩]

determination method or standard: ISS, IEA

cellular response to fluid shear stress[୧୩]

determination method or standard: IEA

positive regulation of synaptic plasticity[୧୩]

determination method or standard: IEA

regulation of blood pressure[୧୧][୧୨][୧୩]

determination method or standard: ISS, IEA

response to lipopolysaccharide[୧୩]

determination method or standard: IEA

positive regulation of platelet-derived growth factor production[୩୨][୧୩]

determination method or standard: ISS, IEA

regulation of inflammatory response[୨୨]

determination method or standard: NAS

brown fat cell differentiation[୧୩]

determination method or standard: IEA

sensory perception of pain[୧୩]

determination method or standard: IEA

response to radiation[୧୩]

determination method or standard: IEA

prostaglandin biosynthetic process[୩୩][୧୧][୧୦][୧୨][୧୩]

determination method or standard: NAS, ISS, IEA

cellular response to ATP[୧୩]

determination method or standard: IEA

ovulation[୧୩]

determination method or standard: IEA

positive regulation of smooth muscle cell proliferation[୧୩]

determination method or standard: IEA

hair cycle[୧୩]

determination method or standard: IEA

response to estradiol[୧୩]

determination method or standard: IEA

positive regulation of cell death[୧୩]

determination method or standard: IEA

positive regulation of cell migration involved in sprouting angiogenesis[୩୪][୧୩]

determination method or standard: ISS, IEA

response to organic cyclic compound[୧୩]

determination method or standard: IEA

lipid metabolism[୧୦]

determination method or standard: IEA

positive regulation of nitric oxide biosynthetic process[୩୪][୧୩]

determination method or standard: ISS, IEA

response to glucocorticoid[୧୩]

determination method or standard: IEA

cyclooxygenase pathway[୩୦][୧୨][୧୩][୨୪]

determination method or standard: IDA, TAS, IEA

fatty acid metabolic process[୧୦]

determination method or standard: IEA

positive regulation of fibroblast growth factor production[୩୪][୧୩]

determination method or standard: ISS, IEA

decidualization[୧୩]

determination method or standard: IEA

regulation of cell population proliferation[୧୩]

determination method or standard: IEA

positive regulation of cell population proliferation[୧୩]

determination method or standard: IEA

negative regulation of calcium ion transport[୧୩]

determination method or standard: IEA

positive regulation of apoptotic process[୧୩]

determination method or standard: IEA

positive regulation of transforming growth factor beta production[୩୪][୧୩]

determination method or standard: ISS, IEA

positive regulation of vascular endothelial growth factor production[୩୪][୧୩]

determination method or standard: ISS, IEA

positive regulation of brown fat cell differentiation[୩୫][୧୩]

determination method or standard: ISS, IEA

negative regulation of synaptic transmission, dopaminergic[୧୩]

determination method or standard: IEA

cellular oxidant detoxification[୩୬]

determination method or standard: IEA

ageing[୧୩]

determination method or standard: IEA

NAD biosynthesis via nicotinamide riboside salvage pathway[୩୦]

determination method or standard: TAS

cellular response to heat[୧୩]

determination method or standard: IEA

positive regulation of prostaglandin biosynthetic process[୩୩][୧୩]

determination method or standard: IEA, NAS

positive regulation of peptidyl-serine phosphorylation[୧୩]

determination method or standard: IEA

negative regulation of apoptotic process[୧୩]

determination method or standard: IEA

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[୧୩]

determination method or standard: IEA

cellular response to non-ionic osmotic stress[୧୩]

determination method or standard: IEA

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress[୧୩]

determination method or standard: IEA

cellular response to lead ion[୧୩]

determination method or standard: IEA

response to angiotensin[୧୩]

determination method or standard: IEA

prostaglandin metabolic process[୧୦]

determination method or standard: IEA

positive regulation of protein import into nucleus[୧୩]

determination method or standard: IEA

cytokine-mediated signaling pathway[୩୦]

determination method or standard: TAS

long-chain fatty acid biosynthetic process[୩୦]

determination method or standard: TAS

negative regulation of cell cycle[୧୩]

determination method or standard: IEA

regulation of neuroinflammatory response[୧୧][୧୩]

determination method or standard: IEA, ISS

physically interacts with

ଆସ୍ପିରିନ‎‎[୩୭]

ବ୍ୟବହାର: enzyme inhibitor

benzquinamide[୩୮]

ବ୍ୟବହାର: enzyme inhibitor

carprofen[୩୯]

ବ୍ୟବହାର: enzyme inhibitor

ସେଲେକକ୍ସିବ[୪୦]

ବ୍ୟବହାର: enzyme inhibitor

ଡାଇକ୍ଲୋଫେନାକ[୪୧]

ବ୍ୟବହାର: enzyme inhibitor

ଇଟୋଡୋଲାକ[୪୨]

ବ୍ୟବହାର: enzyme inhibitor

etoricoxib[୪୩]

ବ୍ୟବହାର: enzyme inhibitor

ଫ୍ଲର୍ବିପ୍ରୋଫେନ[୪୪]

ବ୍ୟବହାର: enzyme inhibitor

ଆଇବୁପ୍ରୋଫେନ୍[୪୫]

ବ୍ୟବହାର: enzyme inhibitor

କେଟୋପ୍ରୋଫେନ[୪୬]

ବ୍ୟବହାର: enzyme inhibitor

କେଟୋରୋଲାକ[୪୭]

ବ୍ୟବହାର: enzyme inhibitor

lumiracoxib[୪୮]

ବ୍ୟବହାର: enzyme inhibitor

ମେଫେନାମିକ୍ ଏସିଡ[୫୦]

ବ୍ୟବହାର: enzyme inhibitor

ମେଲୋକ୍ସିକାମ[୫୧]

ବ୍ୟବହାର: enzyme inhibitor

ନାପ୍ରୋକ୍ସେନ[୫୨]

ବ୍ୟବହାର: enzyme inhibitor

ନିମେସୁଲାଇଡ[୫୩]

ବ୍ୟବହାର: enzyme inhibitor

NS-398[୫୪]

ବ୍ୟବହାର: enzyme inhibitor

ଅକ୍ସାପ୍ରୋଜିନ[୫୫]

ବ୍ୟବହାର: enzyme inhibitor

ପାରାସେଟାମୋଲ[୫୬]

ବ୍ୟବହାର: enzyme inhibitor

phenylbutazone[୫୭]

ବ୍ୟବହାର: enzyme inhibitor

ପିରୋକ୍ସିକାମ[୫୮]

ବ୍ୟବହାର: enzyme inhibitor

resveratrol[୫୯]

ବ୍ୟବହାର: enzyme inhibitor

rofecoxib[୬୦]

ବ୍ୟବହାର: enzyme inhibitor

suprofen[୬୧]

ବ୍ୟବହାର: enzyme inhibitor

valdecoxib[୬୨]

ବ୍ୟବହାର: enzyme inhibitor

ନାପ୍ରୋକ୍ସେନ[୬୩]

object of statement has role: reaction inhibitor

diclofenac sodium[୬୪]

object of statement has role: reaction inhibitor

iguratimod[୬୫]

object of statement has role: reaction inhibitor

ଅକ୍ସାପ୍ରୋଜିନ[୬୬]

object of statement has role: reaction inhibitor

apricoxib[୬୭]

object of statement has role: reaction inhibitor

ଆସ୍ପିରିନ‎‎[୬୮]

object of statement has role: reaction inhibitor

ଆଇବୁପ୍ରୋଫେନ୍[୬୯]

object of statement has role: reaction inhibitor

polmacoxib[୭୦]

object of statement has role: reaction inhibitor

କେଟୋରୋଲାକ[୭୧]

object of statement has role: reaction inhibitor

isoxicam[୭୨]

object of statement has role: reaction inhibitor

ଡାଇକ୍ଲୋଫେନାକ[୭୩]

object of statement has role: reaction inhibitor

ଇଟୋଡୋଲାକ[୭୪]

object of statement has role: reaction inhibitor

ବ୍ରୋମଫେନାକ[୭୫]

object of statement has role: reaction inhibitor

ଫେନୋପ୍ରୋଫେନ[୭୬]

object of statement has role: reaction inhibitor

ଡିଫ୍ଲୁନିସାଲ[୭୭]

object of statement has role: reaction inhibitor

esflurbiprofen[୭୮]

object of statement has role: reaction inhibitor

diclofenac potassium[୭୯]

object of statement has role: reaction inhibitor

(RS)-fenoprofen calcium dihydrate[୮୦]

object of statement has role: reaction inhibitor

ketorolac tromethamine[୮୧]

object of statement has role: reaction inhibitor

naproxen sodium[୮୨]

object of statement has role: reaction inhibitor

tolmetin sodium[୮୩]

object of statement has role: reaction inhibitor

EC enzyme number

1.14.99.1

ଏହାର ଅଂଶ

EGF-like domain[]

କମନ୍ସ ଶ୍ରେଣୀ

Cyclooxygenase 2

ଆଧାର

  1. Freebase Data Dumps, ୨୮ ଅକ୍ଟୋବର 2013
  2. NCBI Gene, ୩୦ ମଇ 2020, 5743
  3. ୩.୦ ୩.୧ ୩.୨ ୩.୩ ୩.୪ ୩.୫ P35354, ୯ ଅଗଷ୍ଟ 2016, ଇଂରାଜୀ ଭାଷା, UniProt
  4. Ensembl Release 99, ENSP00000356438
  5. Ensembl Release 99, ENSP00000454130
  6. ୬.୦ ୬.୧ ୬.୨ ୬.୩ UniProt, ୧୩ ନଭେମ୍ବର 2019, P35354
  7. ୭.୦ ୭.୧ ୭.୨ ୭.୩ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P35354
  8. inferred from protein domain or family
  9. ୯.୦ ୯.୧ ୯.୨ ୯.୩ Reactome, ୭ ନଭେମ୍ବର 2018, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354
  10. ୧୦.୦୦ ୧୦.୦୧ ୧୦.୦୨ ୧୦.୦୩ ୧୦.୦୪ ୧୦.୦୫ ୧୦.୦୬ ୧୦.୦୭ ୧୦.୦୮ ୧୦.୦୯ ୧୦.୧୦ ୧୦.୧୧ ୧୦.୧୨ ୧୦.୧୩ ୧୦.୧୪ ୧୦.୧୫ GOA, ୯ ମଇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, IEA
  11. ୧୧.୦ ୧୧.୧ ୧୧.୨ ୧୧.୩ ୧୧.୪ GOA, ୯ ମଇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ISS
  12. ୧୨.୦ ୧୨.୧ ୧୨.୨ ୧୨.୩ ୧୨.୪ ୧୨.୫ ୧୨.୬ ୧୨.୭ InterPro, ୯ ମଇ 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
  13. ୧୩.୦୦ ୧୩.୦୧ ୧୩.୦୨ ୧୩.୦୩ ୧୩.୦୪ ୧୩.୦୫ ୧୩.୦୬ ୧୩.୦୭ ୧୩.୦୮ ୧୩.୦୯ ୧୩.୧୦ ୧୩.୧୧ ୧୩.୧୨ ୧୩.୧୩ ୧୩.୧୪ ୧୩.୧୫ ୧୩.୧୬ ୧୩.୧୭ ୧୩.୧୮ ୧୩.୧୯ ୧୩.୨୦ ୧୩.୨୧ ୧୩.୨୨ ୧୩.୨୩ ୧୩.୨୪ ୧୩.୨୫ ୧୩.୨୬ ୧୩.୨୭ ୧୩.୨୮ ୧୩.୨୯ ୧୩.୩୦ ୧୩.୩୧ ୧୩.୩୨ ୧୩.୩୩ ୧୩.୩୪ ୧୩.୩୫ ୧୩.୩୬ ୧୩.୩୭ ୧୩.୩୮ ୧୩.୩୯ ୧୩.୪୦ ୧୩.୪୧ ୧୩.୪୨ ୧୩.୪୩ ୧୩.୪୪ ୧୩.୪୫ ୧୩.୪୬ ୧୩.୪୭ ୧୩.୪୮ ୧୩.୪୯ ୧୩.୫୦ ୧୩.୫୧ ୧୩.୫୨ ୧୩.୫୩ ୧୩.୫୪ ୧୩.୫୫ ୧୩.୫୬ ୧୩.୫୭ ୧୩.୫୮ ୧୩.୫୯ ୧୩.୬୦ ୧୩.୬୧ ୧୩.୬୨ ୧୩.୬୩ ୧୩.୬୪ ୧୩.୬୫ ୧୩.୬୬ ୧୩.୬୭ ୧୩.୬୮ ୧୩.୬୯ ୧୩.୭୦ ୧୩.୭୧ ୧୩.୭୨ ୧୩.୭୩ ୧୩.୭୪ Ensembl genome database project, ୯ ମଇ 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
  14. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, ୯ ମଇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, IPI
  15. Parkinsons Disease Gene Ontology Initiative, ୯ ମଇ 2019, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
  16. Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, ୭ ନଭେମ୍ବର 2018, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, NAS
  17. ୧୭.୦ ୧୭.୧ GOA, ୭ ନଭେମ୍ବର 2018, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, IEA
  18. ୧୮.୦ ୧୮.୧ InterPro, ୭ ନଭେମ୍ବର 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354
  19. ୧୯.୦ ୧୯.୧ Ensembl genome database project, ୭ ନଭେମ୍ବର 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354
  20. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, ୭ ନଭେମ୍ବର 2018, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, IDA
  21. British Heart Foundation, ୭ ନଭେମ୍ବର 2018, Human cyclooxygenase-2 cDNA, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354
  22. ୨୨.୦ ୨୨.୧ Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, ୯ ମଇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, NAS
  23. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, ୯ ମଇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, IDA
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