Prostaglandin-endoperoxide synthase 2
human enzyme involved in inflammation
ଏହା ଯାହାର ଅଂଶ
Prostaglandin G/H synthase 2[୭]
Haem peroxidase domain superfamily, animal type[୭]
Haem peroxidase superfamily[୭]
EGF-like domain, protein family[୮]
found in taxon
Homo sapiens[୬]
encoded by
PTGS2[୬]
molecular function
prostaglandin-endoperoxide synthase activity[୯][୧୭][୧୮][୧୯][୨୦][୨୧]
determination method: IEA, IDA, TAS
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[୯][୧୯]
determination method: IEA, TAS
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[୧୩]
determination method: IEA
cell component
biological process
positive regulation of platelet-derived growth factor production[୩୨][୧୩]
determination method: ISS, IEA
positive regulation of cell migration involved in sprouting angiogenesis[୩୪][୧୩]
determination method: ISS, IEA
positive regulation of transforming growth factor beta production[୩୪][୧୩]
determination method: ISS, IEA
positive regulation of vascular endothelial growth factor production[୩୪][୧୩]
determination method: ISS, IEA
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[୧୩]
determination method: IEA
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress[୧୩]
determination method: IEA
physically interacts with
EC enzyme number
1.14.99.1
exact match
ଏହାର ଅଂଶ
EGF-like domain[୭]
କମନ୍ସ ଶ୍ରେଣୀ
Cyclooxygenase 2
ଆଧାର
- ↑ Freebase Data Dumps, ୨୮ ଅକ୍ଟୋବର 2013
- ↑ NCBI Gene, ୩୦ ମଇ 2020, 5743
- ↑ ୩.୦ ୩.୧ ୩.୨ ୩.୩ ୩.୪ ୩.୫ P35354, ୯ ଅଗଷ୍ଟ 2016, UniProt, ଇଂରାଜୀ ଭାଷା
- ↑ Ensembl Release 99, ENSP00000356438
- ↑ Ensembl Release 99, ENSP00000454130
- ↑ ୬.୦ ୬.୧ ୬.୨ ୬.୩ UniProt, ୧୩ ନଭେମ୍ବର 2019, P35354
- ↑ ୭.୦ ୭.୧ ୭.୨ ୭.୩ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P35354
- ↑ inferred from protein domain or family
- ↑ ୯.୦ ୯.୧ ୯.୨ ୯.୩ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ୭ ନଭେମ୍ବର 2018, Reactome, GOA
- ↑ ୧୦.୦୦ ୧୦.୦୧ ୧୦.୦୨ ୧୦.୦୩ ୧୦.୦୪ ୧୦.୦୫ ୧୦.୦୬ ୧୦.୦୭ ୧୦.୦୮ ୧୦.୦୯ ୧୦.୧୦ ୧୦.୧୧ ୧୦.୧୨ ୧୦.୧୩ ୧୦.୧୪ ୧୦.୧୫ IEA, ୯ ମଇ 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ ୧୧.୦ ୧୧.୧ ୧୧.୨ ୧୧.୩ ୧୧.୪ ISS, ୯ ମଇ 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ ୧୨.୦ ୧୨.୧ ୧୨.୨ ୧୨.୩ ୧୨.୪ ୧୨.୫ ୧୨.୬ ୧୨.୭ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, InterPro, GOA
- ↑ ୧୩.୦୦ ୧୩.୦୧ ୧୩.୦୨ ୧୩.୦୩ ୧୩.୦୪ ୧୩.୦୫ ୧୩.୦୬ ୧୩.୦୭ ୧୩.୦୮ ୧୩.୦୯ ୧୩.୧୦ ୧୩.୧୧ ୧୩.୧୨ ୧୩.୧୩ ୧୩.୧୪ ୧୩.୧୫ ୧୩.୧୬ ୧୩.୧୭ ୧୩.୧୮ ୧୩.୧୯ ୧୩.୨୦ ୧୩.୨୧ ୧୩.୨୨ ୧୩.୨୩ ୧୩.୨୪ ୧୩.୨୫ ୧୩.୨୬ ୧୩.୨୭ ୧୩.୨୮ ୧୩.୨୯ ୧୩.୩୦ ୧୩.୩୧ ୧୩.୩୨ ୧୩.୩୩ ୧୩.୩୪ ୧୩.୩୫ ୧୩.୩୬ ୧୩.୩୭ ୧୩.୩୮ ୧୩.୩୯ ୧୩.୪୦ ୧୩.୪୧ ୧୩.୪୨ ୧୩.୪୩ ୧୩.୪୪ ୧୩.୪୫ ୧୩.୪୬ ୧୩.୪୭ ୧୩.୪୮ ୧୩.୪୯ ୧୩.୫୦ ୧୩.୫୧ ୧୩.୫୨ ୧୩.୫୩ ୧୩.୫୪ ୧୩.୫୫ ୧୩.୫୬ ୧୩.୫୭ ୧୩.୫୮ ୧୩.୫୯ ୧୩.୬୦ ୧୩.୬୧ ୧୩.୬୨ ୧୩.୬୩ ୧୩.୬୪ ୧୩.୬୫ ୧୩.୬୬ ୧୩.୬୭ ୧୩.୬୮ ୧୩.୬୯ ୧୩.୭୦ ୧୩.୭୧ ୧୩.୭୨ ୧୩.୭୩ ୧୩.୭୪ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Ensembl genome database project, GOA
- ↑ IPI, ୯ ମଇ 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
- ↑ NAS, ୭ ନଭେମ୍ବର 2018, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
- ↑ ୧୭.୦ ୧୭.୧ IEA, ୭ ନଭେମ୍ବର 2018, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
- ↑ ୧୮.୦ ୧୮.୧ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ୭ ନଭେମ୍ବର 2018, InterPro, GOA
- ↑ ୧୯.୦ ୧୯.୧ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ୭ ନଭେମ୍ବର 2018, Ensembl genome database project, GOA
- ↑ IDA, ୭ ନଭେମ୍ବର 2018, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ୭ ନଭେମ୍ବର 2018, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
- ↑ ୨୨.୦ ୨୨.୧ NAS, ୯ ମଇ 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ IDA, ୯ ମଇ 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ ୨୪.୦ ୨୪.୧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
- ↑ IDA, ୯ ମଇ 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Mouse Genome Informatics, Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Human Protein Atlas, GOA
- ↑ ୩୦.୦ ୩୦.୧ ୩୦.୨ ୩୦.୩ ୩୦.୪ ୩୦.୫ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Reactome, GOA
- ↑ IEP, ୯ ମଇ 2019, P35354, Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ ୩୨.୦ ୩୨.୧ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, GOA
- ↑ ୩୩.୦ ୩୩.୧ NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
- ↑ ୩୪.୦ ୩୪.୧ ୩୪.୨ ୩୪.୩ ୩୪.୪ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, Cyclooxygenase regulates angiogenesis induced by colon cancer cells, GOA
- ↑ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
- ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ୯ ମଇ 2019, Gene Ontology Consortium, GOA
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 4139, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7124, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7141, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 2892, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 2714, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7185, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 2896, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 4194, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 2713, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 4795, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 6661, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 2897, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7219, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 2593, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7220, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 5230, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7401, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 8976, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7252, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 5239, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7270, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7273, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 8741, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 2893, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 7298, ଇଂରାଜୀ ଭାଷା
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ୧୭ ଅଗଷ୍ଟ 2016, 2894, ଇଂରାଜୀ ଭାଷା
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL154
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL1034
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL2107455
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL1071
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL1835207
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL25
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL521
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL166863
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL469
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL53292
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL139
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL622
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL1077
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL1297
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL898
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL435298
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL1200804
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL2103736
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL1201124
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL1200806
- ↑ Open Targets Platform, ୧୪ ଅଗଷ୍ଟ 2023, https://platform.opentargets.org/drug/CHEMBL1200613
- ↑ Identifiers.org