ଭାଲସାର୍ଟାନ

ଭାଲସାର୍ଟାନ
Clinical data
Trade names	Diovan, others
AHFS/Drugs.com	monograph
MedlinePlus	a697015
data	EU EMA: yes; US DailyMed: Valsartan;
Pregnancy; category	AU: D ; US: N (Not classified yet) ;
Routes of; administration	By mouth
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	25%
Protein binding	95%
Elimination half-life	6 hours
Excretion	Kidney 30%, biliary 70%
Identifiers
	IUPAC name (S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}pentanamido)butanoic acid;
ECHA InfoCard	100.113.097
Chemical and physical data
Formula	C24H29N5O3
Molar mass	୪୩୫.୫୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O;
	InChI InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1 ; Key:ACWBQPMHZXGDFX-QFIPXVFZSA-N ;
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ଭାଲସାର୍ଟାନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ବାଣିଜ୍ୟ ନା ଡିଭୋଭାନ ଏକ ଔଷଧ ଯାହା ଉଚ୍ଚ ରକ୍ତଚାପ, ହୃଦଘାତ ଏବଂ ମଧୁମେହ କିଡନୀ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୩] ଉଚ୍ଚ ରକ୍ତଚାପ ପାଇଁ ଏହା ଏକ ଯୁକ୍ତିଯୁକ୍ତ ପ୍ରାରମ୍ଭିକ ଚିକିତ୍ସା | ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୪] ଏହାର କେତେକ ମିଶ୍ରଣ ଭାବରେ ସଂସ୍କରଣ ମଧ୍ୟ ଉପଲବ୍ଧ ଯେପରିକି ଭାଲ୍‌ସାର୍ଟାନ/ହାଇଡ୍ରୋକ୍ଲୋରୋଥିଆଜାଇଡ, ଭାଲ୍‌ସାର୍ଟାନ/ଆମଲୋଡିପାଇନ, ଭାଲ୍‌ସାର୍ଟାନ/ଆମଲୋଡିପାଇନ/ହାଇଡ୍ରୋକ୍ଲୋରୋଥିଆଜାଇଡ କିମ୍ବା ଭାଲ୍‌ସାର୍ଟାନ/ସାଲିବିଟ୍ରିଲ | ^[୪] ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କ୍ଳାନ୍ତ ଅନୁଭବ, ମୁଣ୍ଡ ବୁଲାଇବା, ଉଚ୍ଚ ରକ୍ତ ପୋଟାସିୟମ୍, ତରଳ ଝାଡ଼ା ଏବଂ ଗଣ୍ଠି ଯନ୍ତ୍ରଣା ଅନ୍ତର୍ଭୁକ୍ତ | ^[୩] ଅନ୍ୟାନ୍ୟ ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କିଡନୀ ସମସ୍ୟା,ନିମ୍ନ ରକ୍ତଚାପ ଏବଂ ଆଞ୍ଜିଓଇଡିମା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ | ^[୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ ଏବଂ ସ୍ତନ୍ୟପାନ କରାଇବା ପରାମର୍ଶ ଦିଆଯାଇନଥାଏ | ^[୬] ଏହା ଏକ ଆଞ୍ଜିଓଟେନସିନ୍ ୨ ରିସେପ୍ଟର ବ୍ଲକର୍ସ ଏବଂ ଆଞ୍ଜିଓଟେନସିନ ୨ର ପ୍ରଭାବକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ | ^[୪]

୧୯୯୦ ମସିହାରେ ଭାଲସାର୍ଟାନ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୯୬ରେ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା । ^[୭] ଏହା ଏକ ସାଧାରଣ ଔଷଷ ଭାବରେ ଉପଲବ୍ଧ | ^[୮] ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସର ଯୋଗାଣ ୨୦୧୯ସୁଦ୍ଧା ମାସକୁ ୫ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିଥାଏ | ^[୯] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୭.୫୦ ଆମେରିକୀୟ ଡଲାର ଅଟେ | ^[୧୦] ୨୦୧୭ରେ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୮୫ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ନଅ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୧୧] ^[୧୨]

ଆଧାର

1 2 "Valsartan Use During Pregnancy". Drugs.com. 28 March 2019. Archived from the original on 20 April 2020. Retrieved 12 February 2020.
↑ "Valsartan 160 mg capsules - Summary of Product Characteristics (SmPC)". (emc). 19 February 2019. Archived from the original on 13 February 2020. Retrieved 12 February 2020.
1 2 "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
1 2 3 4 5 "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
↑ "Sacubitril and Valsartan Monograph for Professionals". Drugs.com. 7 November 2019. Archived from the original on 4 January 2020. Retrieved 12 February 2020.
↑ "Valsartan Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 20 April 2020. Retrieved 3 March 2019.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 470. ISBN 9783527607495. Archived from the original on 12 June 2020. Retrieved 1 March 2019.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
↑ "Valsartan - Drug Usage Statistics". ClinCalc. Archived from the original on 11 April 2020. Retrieved 11 April 2020.

[Drugs.com_pregnancy-1] 1 2 "Valsartan Use During Pregnancy". Drugs.com. 28 March 2019. Archived from the original on 20 April 2020. Retrieved 12 February 2020.

[2] "Valsartan 160 mg capsules - Summary of Product Characteristics (SmPC)". (emc). 19 February 2019. Archived from the original on 13 February 2020. Retrieved 12 February 2020.

[AHFS2019-3] 1 2 "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 3 March 2019.

[autogen3-4] 1 2 3 4 5 "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 3 March 2019.

[Entresto_AHFS-5] "Sacubitril and Valsartan Monograph for Professionals". Drugs.com. 7 November 2019. Archived from the original on 4 January 2020. Retrieved 12 February 2020.

[Preg2019-6] "Valsartan Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 20 April 2020. Retrieved 3 March 2019.

[Fis2006-7] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 470. ISBN 9783527607495. Archived from the original on 12 June 2020. Retrieved 1 March 2019.

[BNF76-8] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.

[autogen1-9] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.

[NADAC2019-10] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.

[ref-11] "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.

[ref1-12] "Valsartan - Drug Usage Statistics". ClinCalc. Archived from the original on 11 April 2020. Retrieved 11 April 2020.

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