ସେଫୁରୋକ୍ସାଇମ

ସେଫୁରୋକ୍ସାଇମ
Clinical data
Trade names	Zinacef, Ceftin, others
AHFS/Drugs.com	monograph
MedlinePlus	a601206
data	US DailyMed: Cefuroxime;
Pregnancy; category	B;
Routes of; administration	Intramuscular, intravenous, by mouth
Legal status
Legal status	AU: S4 (Prescription only) ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	37% on an empty stomach, up to 52% if taken after food
Elimination half-life	80 minutes
Excretion	Urine 66–100% unchanged
Identifiers
	IUPAC name (6R,7R)-3-{[(Aminocarbonyl)oxy]methyl}-7-{[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
ECHA InfoCard	100.054.127
Chemical and physical data
Formula	C16H16N4O8S
Molar mass	୪୨୪.୩୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)\c3occc3)COC(=O)N)C(=O)O;
	InChI InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9+/t10-,14-/m1/s1 ; Key:JFPVXVDWJQMJEE-SWWZKJRFSA-N ;
(verify)

ସେଫୁରୋକ୍ସାଇମ, ଏକ ବିକ୍ରୟ ନାମ ଜିନାସେଫ୍, ହେଉଛି ଏକ ଆଣ୍ଟିବାୟୋଟିକ ଯାହା ଅନେକ ଗୁଡ଼ିଏ ସଂକ୍ରମଣର ପ୍ରତିଷେଧ ଓ ଚିକିତ୍ସାରେ ବ୍ୟବ‌ହୃତ ହୁଏ ।^[୧] ଏଥିମଧ୍ୟରେ ନିମୋନିଆ, ମେନିଞ୍ଜାଇଟିସ୍, ମଧ୍ୟକର୍ଣ୍ଣ ପ୍ରଦାହ, ସେପସିସ୍, ମୂତ୍ରାଙ୍ଗ ସଂକ୍ରମଣ ଏବଂ ଲାଇମ୍ ରୋଗ ଅନ୍ତର୍ଭୁକ୍ତ। ^[୨] ଏହା ପାଟିରେ କିମ୍ବା ଶିରା ଅଥବା ମାଂସପେଶୀରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ତରଳ ଝାଡ଼ା, ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ଏବଂ ଇଞ୍ଜେକସନ ସ୍ଥାନରେ ଯନ୍ତ୍ରଣା ହୋଇପାରେ ।^[୨] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କ୍ଲୋଷ୍ଟ୍ରିଡିଅମ ଡିଫିସିଲ୍ ସଂକ୍ରମଣ, ଆନାଫାଇଲକ୍ସିସ୍ ଏବଂ ଷ୍ଟିଭେନ୍ସ - ଜନସନ ସିଣ୍ଡ୍ରୋମ ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଏବଂ ସ୍ତନ୍ୟପାନ ନିରାପଦ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ । ^[୪] ଏହା ଏକ ଦ୍ୱିତୀୟ ପିଢ଼ୀର ସେଫାଲୋସ୍ପୋରିନ ଔଷଧ ଯାହା ଜୀବାଣୁଙ୍କର କୋଷ ପ୍ରାଚୀର ତିଆରି କରିବାରେ ବାଧା ପ୍ରଦାନ କରିବା ଫଳରେ ମୃତ୍ୟୁ ହୁଏ ।^[୩]

୧୯୭୧ ମସିହାରେ ସେଫୁରୋକ୍ସାଇମ୍ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୭୭ ମସିହାରେ ଚିକିତ୍ସାରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ତାଲିକାରେ ଏହାର ନାମ ଅଛି । ^[୬] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୧] ଯୁକ୍ତରାଜ୍ୟରେ ପାଟିଦ୍ୱାରା ନିଆଯାଉଥିବା ଏକ ସପ୍ତାହ ଚିକିତ୍ସା ନିମନ୍ତେ ୨୦୧୯ ସୁଦ୍ଧା ମୂଲ୍ୟ £ ୧୮ ଅଟେ ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୮.୫୦ ଡଲାର ଅଟେ । ^[୮] ୨୦୧୭ରେ ଏହା ୮୦୦ ହଜାରରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ସହିତ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୩୪୨ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା । ^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 518. ISBN 9780857113382.
↑ ^୨.୦ ^୨.୧ "Cefuroxime Sodium Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 22 March 2019. Retrieved 22 March 2019.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Cefuroxime Sodium Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 22 March 2019. Retrieved 22 March 2019.
↑ "Cefuroxime Use During Pregnancy". Drugs.com. Archived from the original on 22 March 2019. Retrieved 3 March 2019.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 493. ISBN 9783527607495. Archived from the original on 2 March 2019. Retrieved 2 March 2019.
↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 518. ISBN 9780857113382.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
↑ "Cefuroxime - Drug Usage Statistics". ClinCalc. Archived from the original on 19 June 2020. Retrieved 11 April 2020.

[BNF76-1] ୧.୦ ^୧.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 518. ISBN 9780857113382.

[AHFS2019-2] ୨.୦ ^୨.୧ "Cefuroxime Sodium Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 22 March 2019. Retrieved 22 March 2019.

[autogen1-3] ୩.୦ ^୩.୧ ^୩.୨ "Cefuroxime Sodium Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 22 March 2019. Retrieved 22 March 2019.

[Preg2019-4] "Cefuroxime Use During Pregnancy". Drugs.com. Archived from the original on 22 March 2019. Retrieved 3 March 2019.

[Fis2006-5] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 493. ISBN 9783527607495. Archived from the original on 2 March 2019. Retrieved 2 March 2019.

[WHO21st-6] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[autogen4-7] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 518. ISBN 9780857113382.

[NADAC2019-8] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.

[ref-9] "Cefuroxime - Drug Usage Statistics". ClinCalc. Archived from the original on 19 June 2020. Retrieved 11 April 2020.

[୧]

[୨]

[୩]

[୪]

[୫]

[୬]

[୭]

[୮]

[୯]