ସେଫଡିନିର

ସେଫଡିନିର
Clinical data
Pronunciation	SEF-di-nir
Trade names	Cefzon, Omnicef, others
AHFS/Drugs.com	monograph
MedlinePlus	a698001
data	US DailyMed: Cefdinir;
Routes of; administration	By mouth
ATC code	J01DD15 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	16% to 21% (dose-dependent)
Protein binding	60% to 70%
Metabolism	Negligible
Elimination half-life	1.7 ± 0.6 hours
Excretion	Kidney
Identifiers
	IUPAC name 8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso-; ethenyl]amino-4-ethenyl-7-oxo-2-thia-6-; azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid;
CAS Number	91832-40-5 ;
PubChem CID	6915944;
DrugBank	DB00535 ;
ChemSpider	5291705 ;
UNII	CI0FAO63WC;
KEGG	D00917 ;
ChEBI	CHEBI:3485 ;
ChEMBL	CHEMBL927 ;
ECHA InfoCard	100.171.145
Chemical and physical data
Formula	C14H13N5O5S2
Molar mass	୩୯୫.୪୧ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	170 °C (338 °F) (dec.)
	SMILES O=C2N1/C(=C(/C=C)CS[C@@H]1[C@@H]2NC(=O)C(=N\O)/c3nc(sc3)N)C(=O)O;
	InChI InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1 ; Key:RTXOFQZKPXMALH-GHXIOONMSA-N ;
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ସେଫଡିନିର, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଓମନିସେଫ୍, ଏକ ଆଣ୍ଟିବାୟୋଟିକ ଯାହା ନିମୋନିଆ, ସେଲ୍ୟୁଲାଇଟିସ୍, ମଧ୍ୟକର୍ଣ୍ଣ ପ୍ରଦାହ, ଷ୍ଟ୍ରେପ୍ଟୋକୋକାଲ ଫାରିଞ୍ଜାଇଟିସ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୧] ମଧ୍ୟକର୍ଣ୍ଣ ପ୍ରଦାହ, ଷ୍ଟ୍ରେପ୍ଟୋକୋକାଲ ଫାରିଞ୍ଜାଇଟିସ ଓ ନିମୋନିଆ ପାଇଁ ଏହା ଏକ କମ୍ ପସନ୍ଦଯୋଗ୍ୟ ବିକଳ୍ପ, ପେନିସିଲିନ ଆଲର୍ଜି ଥିଲେ ଏହା ବ୍ୟବ‌ହାର କରାଯାଇପାରିବ । ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ବାନ୍ତି, ଏବଂ ଚର୍ମରୋଗ ଦେଖାଯାଏ | ^[୧] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କ୍ଲୋଷ୍ଟ୍ରିଡିଅମ ଡିଫିସିଲ୍ ସଂକ୍ରମଣ, ଆନାଫାଇଲକ୍‌ସିସ ଏବଂ ଷ୍ଟିଭେନ୍ସ ଜନସନ ସିଣ୍ଡ୍ରୋମ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ | ^[୨] ଗର୍ଭାବସ୍ଥାରେ ଏବଂ ସ୍ତନ୍ୟପାନରେ ବ୍ୟବହାର ନିରାପଦ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ କିନ୍ତୁ ଭଲ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ | ^[୩] ଏହା ଏକ ତୃତୀୟ ପିଢ଼ୀର ସେଫାଲୋସ୍ପୋରନ ଏବଂ ଜୀବାଣୁଙ୍କର କୋଷ ପ୍ରାଚୀର ତିଆରି କରିବାରେ ବାଧା ସୃଷ୍ଟି କରି ଏହାର ମୃତ୍ୟୁରେ ପରିଣତ ହୁଏ | ^[୨]

୧୯୭୯ ମସିହାରେ ଏହା ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୯୧ରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ^[୪] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଦଶ ଦିନର ଔଷଧର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୯.୪୦ ଡଲାର | ^[୫] ୨୦୧୭ରେ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୯୮ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଦୁଇ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ଥିଲା | ^[୬] ^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Cefdinir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 14 August 2019. Retrieved 23 March 2019.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Cefdinir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 14 August 2019. Retrieved 23 March 2019.
↑ "Cefdinir Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 March 2019. Retrieved 3 March 2019.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 49X. ISBN 9783527607495. Archived from the original on 2019-03-06. Retrieved 2019-03-02.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Cefdinir - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

[AHFS2019-1] ୧.୦ ^୧.୧ ^୧.୨ "Cefdinir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 14 August 2019. Retrieved 23 March 2019.

[autogen1-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Cefdinir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 14 August 2019. Retrieved 23 March 2019.

[Preg2019-3] "Cefdinir Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 March 2019. Retrieved 3 March 2019.

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 49X. ISBN 9783527607495. Archived from the original on 2019-03-06. Retrieved 2019-03-02.

[NADAC2019-5] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-6] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[ref1-7] "Cefdinir - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

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