ରାବେପ୍ରାଜୋଲ

ରାବେପ୍ରାଜୋଲ
Clinical data
Pronunciation	/rəˈbɛprəˌzɔːl/
Trade names	AcipHex, Pariet, others
AHFS/Drugs.com	monograph
MedlinePlus	a699060
data	US FDA: Rabeprazole;
Pregnancy; category	US: C (Risk not ruled out) ;
Routes of; administration	By mouth
Drug class	Proton pump inhibitor
ATC code	A02BC04 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	52%
Protein binding	96.3%
Metabolism	CYP2C19 and CYP3A4 in the liver
Metabolites	thioether carboyxlic acid metabolite, thioether glucuronide metabolite, sulfone metabolite
Elimination half-life	~1 hour
Excretion	90% via kidney as metabolites
Identifiers
	IUPAC name (RS)-2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole;
CAS Number	117976-89-3 ;
PubChem CID	5029;
IUPHAR/BPS	7290;
DrugBank	DB01129 ;
ChemSpider	4853 ;
UNII	32828355LL;
ChEBI	CHEBI:8768 ;
ChEMBL	CHEMBL1219 ;
PDB ligand	RZX (PDBe, RCSB PDB);
ECHA InfoCard	100.123.408
Chemical and physical data
Formula	C18H21N3O3S
Molar mass	୩୫୯.୪୪ g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES n1c2ccccc2[nH]c1S(=O)Cc3nccc(c3C)OCCCOC;
	InChI InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21) ; Key:YREYEVIYCVEVJK-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Rabeprazole

ରାବେପ୍ରାଜୋଲ (ଇଂରାଜୀ ଭାଷାରେ Rabeprazole, ଏକ ବ୍ୟବସାୟୀକ ନାମ ପାରିଏଟ/ Pariet) ଏକ ଔଷଧ ଯାହା ପାକସ୍ଥଳୀରେ ଅମ୍ଳ (stomach acid) ପରିମାଣ କମେଇଦିଏ ।^[୫] ଅଧିକ ଅମ୍ଳ କ୍ଷରିତ ହେଉଥିବା ରୋଗ ଯେପରିକି ପେପଟିକ ଅଲସର ଡିଜିଜ (peptic ulcer disease), ଗାସ୍ଟ୍ରୋଏସୋଫେଜିଆଲ ରିଫ୍ଲକ୍ସ ଡିଜିଜ ଓ ଜୋଲିଞ୍ଜର ଏଲିସନସ ଡିଜିଜ (Zollinger–Ellison syndrome) ରୋଗମାନଙ୍କର ଚିକିତ୍ସାରେ ଦିଆଯାଏ ।^[୫] ହେଲିବ୍ୟାକ୍ଟର ପାଇଲୋରି (Helicobacter pylori) ରୋଗରେ ଏହା ଅନ୍ୟାନ୍ୟ ଔଷଧ ସ‌ହିତ ଦିଆଯାଏ ।^[୬] ଅନ୍ୟାନ୍ୟ ପ୍ରୋଟୋନ ପମ୍ପ ଇନହିବିଟର ବା ପିପିଆଇ (proton pump inhibitors/ PPI) ଔଷଧ ସ‌ହ ସମତୁଲ ଭାବରେ କାମ କରେ ।^[୭] ଏହି ଔଷଧ ପାଟିରେ ଦିଆଯାଏ ।^[୫]

ରାବେପ୍ରାଜୋଲର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କୋଷ୍ଠକାଠିନ୍ୟ, ଦୁର୍ବଳ ଅନୁଭବ ଓ ଗଳା ପ୍ରଦାହ ହୋଇପାରେ ।^[୫] ପ୍ରତିକ୍ରିୟା ସାଂଘାତିକ ହେଲେ ଓଷ୍ଟିଓପୋରୋସିସ, ଅଳ୍ପ ରକ୍ତ ମ୍ୟାଗନେସିଅମ (low blood magnesium), କ୍ଲୋସ୍ଟ୍ରିଡିଅମ ଡିଫିସିଲ ସଂକ୍ରମଣ (Clostridium difficile infection) ଓ ନିମୋନିଆ ହୋଇପାରେ ।^[୫] ଗର୍ଭାବସ୍ଥା ଓ ସ୍ତନ୍ୟପାନ ସମୟରେ ଏହାର ନିରାପତ୍ତା ସ୍ପଷ୍ଟ ହୋଇନାହିଁ ।^[୮] ପାକସ୍ଥଳୀର ପାରାଏଟାଲ ଜୀବକୋଷରେ (parietal cell) ଥିବା ହାଇଡ୍ରୋଜେନ ପୋଟାସିଅମ ଏଟିପେଜକୁ (H⁺/K⁺-ATPase) ଅବରୋଧ କରି ଏହା କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୫]

ରାବେପ୍ରାଜୋଲ ସନ ୧୯୮୬ରେ ପେଟେଣ୍ଟ ହେବା ପରେ ସନ ୧୯୯୭ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା । ^[୯] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୬] ସନ ୨୦୧୯ରେ ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ (United Kingdom) ଏନଏଚଏସକୁ (NHS) ଏହାର ଏକ ମାସର ଡୋଜ ପିଛା ପ୍ରାୟ ଏକ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିବାକୁ ପଡ଼ୁଥିଲା ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହି ଔଷଧ ବାବଦ ଏକ ମାସରେ ପ୍ରାୟ ୧୬ ଆମେରିକୀୟ ଡଲାର ଖର୍ଚ୍ଚ ହୁଏ ।^[୧୦] ସନ ୨୦୧୬ରେ ଏହାର ଏକ ନିୟୁତରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ ହୋଇ ସର୍ବାଧିକ ପ୍ରେସକ୍ରିସନ ତାଲିକାର ୨୮୫ ତମ ସ୍ଥାନରେ ଥଲା ।^[୧୧]

ଆଧାର

↑ "ACIPHEX DELAYED-RELEASE TABLETS" (PDF). Eisai, Inc. Archived from the original (PDF) on 23 March 2018. Retrieved 22 March 2018.
1 2 3 4 5 Marelli, Silvia; Pace, Fabio (10 January 2014). "Rabeprazole for the treatment of acid-related disorders". Expert Review of Gastroenterology & Hepatology. 6 (4): 423–435. doi:10.1586/egh.12.18.
1 2 Langtry, HD; Markham, A (October 1999). "Rabeprazole: a review of its use in acid-related gastrointestinal disorders". Drugs. 58 (4): 725–42. doi:10.2165/00003495-199958040-00014. PMID 10551440.
↑ "rabeprazole". pubchem.ncbi.nlm.nih.gov. NCBI. Retrieved 9 October 2017.
1 2 3 4 5 6 "Rabeprazole Sodium Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.
1 2 3 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 82. ISBN 9780857113382.
↑ "[99] Comparative effectiveness of proton pump inhibitors | Therapeutics Initiative". 28 June 2016. Retrieved 14 July 2016.
↑ "Rabeprazole Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 445. ISBN 9783527607495.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ବାହ୍ୟ ଲିଙ୍କ

Drug Information Portal by the NIH

[Rabeprazole_PI_Jan2018_Update-1] "ACIPHEX DELAYED-RELEASE TABLETS" (PDF). Eisai, Inc. Archived from the original (PDF) on 23 March 2018. Retrieved 22 March 2018.

[Marelli_Review_2012-2] 1 2 3 4 5 Marelli, Silvia; Pace, Fabio (10 January 2014). "Rabeprazole for the treatment of acid-related disorders". Expert Review of Gastroenterology & Hepatology. 6 (4): 423–435. doi:10.1586/egh.12.18.

[Langtry_Review-3] 1 2 Langtry, HD; Markham, A (October 1999). "Rabeprazole: a review of its use in acid-related gastrointestinal disorders". Drugs. 58 (4): 725–42. doi:10.2165/00003495-199958040-00014. PMID 10551440.

[PubChem-4] "rabeprazole". pubchem.ncbi.nlm.nih.gov. NCBI. Retrieved 9 October 2017.

[AHFS2019-5] 1 2 3 4 5 6 "Rabeprazole Sodium Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[BNF76-6] 1 2 3 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 82. ISBN 9780857113382.

[TI2016-7] "[99] Comparative effectiveness of proton pump inhibitors | Therapeutics Initiative". 28 June 2016. Retrieved 14 July 2016.

[Preg2019-8] "Rabeprazole Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.

[9] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 445. ISBN 9783527607495.

[NADAC2019-10] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[11] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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