ଡେକ୍ସମିଥାଇଲଫେନିଡେଟ

ଡେକ୍ସମିଥାଇଲଫେନିଡେଟ
Clinical data
Trade names	Focalin, Focalin XR, Attenade, others
Synonyms	d-threo-methylphenidate (D-TMP)
AHFS/Drugs.com	monograph
MedlinePlus	a603014
data	US DailyMed: Dexmethylphenidate;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Dependence; liability	Physical: None Psychological: High
Routes of; administration	By mouth
Legal status
Legal status	AU: S8 (Controlled) ; CA: Schedule III ; DE: Anlage III (Prescription only) ; UK: Class B ; US: Schedule II ;
Pharmacokinetic data
Bioavailability	11–52%
Protein binding	30%
Metabolism	Liver
Elimination half-life	4 hours
Excretion	Kidney
Identifiers
	IUPAC name (R,R)-(+)-Methyl 2-phenyl-2-(2-piperidyl)acetate;
Chemical and physical data
Formula	C14H19NO2
Molar mass	୨୩୩.୩୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C([C@@H]([C@@H]1NCCCC1)C2=CC=CC=C2)OC;
	InChI InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1 ; Key:DUGOZIWVEXMGBE-CHWSQXEVSA-N ;
(verify)

ଡେକ୍ସମିଥାଇଲଫେନିଡେଟ, ଏକ ବ୍ୟବସାୟୀକ ନାମ ଫୋକାଲିନ୍, ହେଉଛି ଏକ ଔଷଧ ଯାହା ୫ ବର୍ଷରୁ ଅଧିକ ବୟସ୍କଙ୍କ ଧ୍ୟାନାଭାବ ଓ ଅତିସକ୍ରିୟତା ବିକାର (ADHD) ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୨] ୪ ସପ୍ତାହ ପରେ ଯଦି କୌଣସି ଉପକାର ଦେଖାଯାଏ ନାହିଁ ତେବେ ଏହାର ବ୍ୟବହାର ବନ୍ଦ କରିବା ଯୁକ୍ତିଯୁକ୍ତ | ^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୩] ତୁରନ୍ତ କର୍ମକ୍ଷମ ସୂତ୍ର ୫ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ ଏବଂ ବର୍ଦ୍ଧିତ କର୍ମକ୍ଷମ ସୂତ୍ର ୧୨ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ | ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପେଟ ଯନ୍ତ୍ରଣା, ଭୋକ କମିବା ଏବଂ ଜ୍ୱର ଅନ୍ତର୍ଭୁକ୍ତ | ^[୨] ଗୁରୁତର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଔଷଧ ଅପବ୍ୟବ‌ହାର, ସାଇକୋସିସ୍, ହଠାତ୍ ହୃଦ୍‌ରୋଘ ମୃତ୍ୟୁ, ମାନିଆ, ଆନାଫାଇଲକ୍‌ସିସ, ବାତ ଏବଂ ବିପଦପୂର୍ଣ୍ଣ ଭାବରେ ଦୀର୍ଘସ୍ଥାୟୀ ଇରେକ୍ସନ୍ ପ୍ରୟାପ୍ରିଜ୍ମ ହୋଇପାରେ | ^[୩] ଗର୍ଭାବସ୍ଥା ଏବଂ ସ୍ତନ୍ୟପାନ ସମୟରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ | ^[୫] ଡେକ୍ସମିଥାଇଲଫେନିଡେଟ୍ ହେଉଛି ଏକ କେନ୍ଦ୍ରୀୟ ସ୍ନାୟୁ ପ୍ରଣାଳୀ ଉତ୍ତେଜକ | ^[୬] ^[୩] ଏହି ରୋଗରେ ଏହି ଔଷଧ କିପରି କାମ କରେ, ତାହା ଅସ୍ପଷ୍ଟ | ^[୩] ଏହା ମିଥାଇଲଫେନିଡେଟର ଅଧିକ ସକ୍ରିୟ ଏନାନ୍ସିଓମର(

) ଅଟେ | ^[୩]

ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୦୧ ମସିହାରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଡେକ୍ସମେଥାଇଲଫେନିଡେଟ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା | ^[୭] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏକ ମାସର ଯୋଗାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୮ ଡଲାର ଅଟେ । ^[୮] ୨୦୧୭ ମସିହାରେ ଏହା ଆମେରିକାର ୧୮୯ ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ତିନି ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା। ^[୯] ^[୧୦] ଏହା ସ୍ୱିଜରଲ୍ୟାଣ୍ଡରେ ମଧ୍ୟ ଉପଲବ୍ଧ | ^[୧୧]

ଆଧାର

↑ "Dexmethylphenidate Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 April 2019.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Dexmethylphenidate Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 15 April 2019.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Dexmethylphenidate Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 15 April 2019.
↑ Mosby's Drug Reference for Health Professions - E-Book. Elsevier Health Sciences. 2013. p. 455. ISBN 9780323187602.
↑ "Dexmethylphenidate Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 April 2019.
↑ Moen MD, Keam SJ (December 2009). "Dexmethylphenidate extended release: a review of its use in the treatment of attention-deficit hyperactivity disorder". CNS Drugs. 23 (12): 1057–83. doi:10.2165/11201140-000000000-00000. PMID 19958043.
↑ "DailyMed - dexmethylphenidate hydrochloride tablet". dailymed.nlm.nih.gov. Retrieved 15 April 2019.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Dexmethylphenidate Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
↑ "Focalin XR". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 April 2019.

[Preg2019-1] "Dexmethylphenidate Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 April 2019.

[AHFS2019-2] ୨.୦ ^୨.୧ ^୨.୨ "Dexmethylphenidate Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 15 April 2019.

[autogen1-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Dexmethylphenidate Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 15 April 2019.

[4] Mosby's Drug Reference for Health Professions - E-Book. Elsevier Health Sciences. 2013. p. 455. ISBN 9780323187602.

[autogen3-5] "Dexmethylphenidate Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 April 2019.

[Moen2009-6] Moen MD, Keam SJ (December 2009). "Dexmethylphenidate extended release: a review of its use in the treatment of attention-deficit hyperactivity disorder". CNS Drugs. 23 (12): 1057–83. doi:10.2165/11201140-000000000-00000. PMID 19958043.

[Daily2019-7] "DailyMed - dexmethylphenidate hydrochloride tablet". dailymed.nlm.nih.gov. Retrieved 15 April 2019.

[NADAC2019-8] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-9] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ref1-10] "Dexmethylphenidate Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.

[11] "Focalin XR". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 April 2019.

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