ଟ୍ରାଜୋଡନ

ଟ୍ରାଜୋଡନ
Clinical data
Trade names	ପୃଥିବୀରେ ଅନେକ ବ୍ରାଣ୍ଡ ନାମରେ ମିଳେ
Synonyms	AF-1161
AHFS/Drugs.com	monograph
MedlinePlus	a681038
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	ପାଟିରେ ଦିଆଯାଏ (ବଟିକା)
ATC code	N06AX05 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: କେବଳ ପ୍ରେସକ୍ରିପସନରେ ମିଳେ । ; UK: POM (Prescription only) ; US: କେବଳ ପ୍ରେସକ୍ରିପସନରେ ମିଳେ । ;
Pharmacokinetic data
Bioavailability	ପାଟିରେ ଦେଲେ: ୬୫%
Protein binding	୮୯–୯୫%
Metabolism	ଯକୃତ (CYP3A4)
Metabolites	mCPP
Onset of action	ପାଟିରେ: ୧ ଘଣ୍ଟା (Tmax)
Elimination half-life	Trazodone IR: ୭ ଘଣ୍ଟା hours; Trazodone ER: ୧୦ ଘଣ୍ଟା ; mCPP: ୪–୮ ଘଣ୍ଟା
Excretion	Urine: ୭୦–୭୫%; Feces: 21%
Identifiers
	IUPAC name 2-{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one;
CAS Number	19794-93-5 ;
PubChem CID	5533;
IUPHAR/BPS	213;
DrugBank	DB00656 ;
ChemSpider	5332 ;
UNII	YBK48BXK30;
KEGG	D08626 ;
ChEBI	CHEBI:9654 ;
ChEMBL	CHEMBL621 ;
ECHA InfoCard	100.039.364
Chemical and physical data
Formula	C19H22ClN5O
Molar mass	371.8641 g/mol
3D model (JSmol)	Interactive image;
	SMILES Clc4cccc(N3CCN(CCCN1/N=C2/C=C\C=C/N2C1=O)CC3)c4;
	InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 ; Key:PHLBKPHSAVXXEF-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Trazodone

ଟ୍ରାଜୋଡନ (ଇଂରାଜୀ ଭାଷାରେ Trazodone) ଏକ ଔଷଧ ଯାହା ଅନେକ ନାମରେ ପୃଥିବୀରେ ବିକ୍ରୟ ହୁଏ,^[୧] ଓ ଏହା ଏକ ଅବସାଦରୋଧୀ ଔଷଧ (antidepressant) ।^[୮] ପ୍ରମୁଖ ଅବସାଦ ବେମାରୀ, ଉଦ୍‌ବେଗ ଅବ୍ୟବସ୍ଥା ଓ ଅନ୍ୟାନ୍ୟ ଔଷଧ ସ‌ହିତ ଆଲକୋହୋଲ ଡିପେଣ୍ଡେନ୍ସ (alcohol dependence) ରୋଗମାନଙ୍କର ଚିକିତ୍ସାରେ ଏହି ଔଷଧ ଦିଆଯାଏ ।^[୮] ପାଟିରେ ଏ ଔଷଧ ଦିଆଯାଏ । ^[୮]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୁଖିଲା ପାଟି, ବେହୋସ ଅନୁଭବ, ବାନ୍ତି ଓ ମୁଣ୍ଡବିନ୍ଧା ହୁଏ ।^[୮] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ସାଂଘାତିକ ହେଲେ ଆତ୍ମହତ୍ୟା, ପ୍ରକଟିତ ବାଇପୋଲାର ଡିଜଅଡର, ଅନିୟମିତ ହୃଦ୍‌ଗତି (irregular heart rate) ଓ ପ୍ରାୟାପିଜ୍ମ ଇତ୍ୟାଦି ଦେଖାଯାଏ ।^[୮] ଗର୍ଭାବସ୍ଥା ବା ସ୍ତନ୍ୟପାନ କରେଇବା ସମୟରେ ଏହାର ପ୍ରତିକ୍ରିୟା ଅସ୍ପଷ୍ଟ ଅଛି ।^[୯] ଏହା ସେରୋଟୋନିନ ଆଣ୍ଟାଗୋନିସ୍ଟ ଓ ରିଅପଟେକ ଇନ‌ହିବିଟର (serotonin antagonist and reuptake inhibitor)/ SARI) ଶ୍ରେଣୀର ଫିନାଇଲପିପେରାଜିନ (phenylpiperazine) ଯୌଗିକ ପଦାର୍ଥ । ^[୧୦]^[୧୧] ଏହାର ଏକ ପ୍ରଶାନ୍ତି କରଣ ପ୍ରଭାବ ମଧ୍ୟ ଅଛି ।^[୧୨]

ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ସନ ୧୯୮୧ରେ ଟ୍ରାଜୋଡନ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୮] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୮] ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ ସନ ୨୦୧୫ରେ ଏହାର ଏକ ମାସର ଔଷଧ ଖର୍ଚ୍ଚ ପ୍ରାୟ ୨୧.୨୩ ପାଉଣ୍ଡ ଥିଲା ।^[୧୨] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ମାସ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ସନ ୨୦୧୮ରେ ୪.୫୩ ଆମେରିକୀୟ ଡଲାର ଥିଲା ।^[୧୩] ସନ ୨୦୧୪ରେ ଏହି ଔଷଧର ୨୬ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ଆସିଥିଲା । ^[୧୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ Drugs.com international listings for Trazodone Page accessed Feb 10, 2016
↑ Lemke, Thomas L.; Williams, David A. (2012). Foye's Principles of Medicinal Chemistry (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 615. ISBN 9781609133450.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. ^{[not in citation given]}
↑ "Trazodone". DrugBank. Retrieved 7 June 2015.
↑ Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross (6 December 2012). Antidepressants: Past, Present and Future. Springer Science & Business Media. pp. 68–. ISBN 978-3-642-18500-7.
↑ "MicroMedex DrugPoints - Trazodone". Pharmacy Choice. Retrieved 20 April 2017.
↑ Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. pp. 460–. ISBN 978-1-58562-523-9.{{cite book}}: CS1 maint: multiple names: authors list (link)
↑ ^୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ ^୮.୬ "Trazodone Hydrochloride". The American Society of Health-System Pharmacists. Retrieved 8 January 2018.
↑ "Trazodone Use During Pregnancy". Drugs.com. Retrieved 7 January 2018.
↑ Stahl, Stephen M. (2008). Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (in ଇଂରାଜୀ). Cambridge University Press. p. 567. ISBN 9780521857024.
↑ Lemke, Thomas L.; Williams, David A. (2008). Foye's Principles of Medicinal Chemistry (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 586. ISBN 9780781768795.
↑ ^୧୨.୦ ^୧୨.୧ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 257–258. ISBN 9780857111562.
↑ "NADAC as of 2018-01-03". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-06-24. Retrieved 7 January 2018.
↑ "Trazodone hydrochloride prescriptions number U.S. 2004-2014". Statista (in ଇଂରାଜୀ). Retrieved 7 January 2018.

ବାହ୍ୟ ଲିଙ୍କ

U.S. National Library of Medicine: Drug Information Portal – Trazodone

[genericnames-1] ୧.୦ ^୧.୧ Drugs.com international listings for Trazodone Page accessed Feb 10, 2016

[2] Lemke, Thomas L.; Williams, David A. (2012). Foye's Principles of Medicinal Chemistry (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 615. ISBN 9781609133450.

[DrugPoint-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. ^{[not in citation given]}

[4] "Trazodone". DrugBank. Retrieved 7 June 2015.

[PreskornStanga2012-5] Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross (6 December 2012). Antidepressants: Past, Present and Future. Springer Science & Business Media. pp. 68–. ISBN 978-3-642-18500-7.

[6] "MicroMedex DrugPoints - Trazodone". Pharmacy Choice. Retrieved 20 April 2017.

[SchatzbergNemeroff2017-7] Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. pp. 460–. ISBN 978-1-58562-523-9.{{cite book}}: CS1 maint: multiple names: authors list (link)

[AHFS2018-8] ୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ ^୮.୬ "Trazodone Hydrochloride". The American Society of Health-System Pharmacists. Retrieved 8 January 2018.

[9] "Trazodone Use During Pregnancy". Drugs.com. Retrieved 7 January 2018.

[10] Stahl, Stephen M. (2008). Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (in ଇଂରାଜୀ). Cambridge University Press. p. 567. ISBN 9780521857024.

[11] Lemke, Thomas L.; Williams, David A. (2008). Foye's Principles of Medicinal Chemistry (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 586. ISBN 9780781768795.

[BNF69-12] ୧୨.୦ ^୧୨.୧ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 257–258. ISBN 9780857111562.

[13] "NADAC as of 2018-01-03". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-06-24. Retrieved 7 January 2018.

[14] "Trazodone hydrochloride prescriptions number U.S. 2004-2014". Statista (in ଇଂରାଜୀ). Retrieved 7 January 2018.

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