ଡମ‌ପେରିଡନ

ଡମ‌ପେରିଡନ
Clinical data
Trade names	Motilium, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	AU: B2 ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth, intramuscular, rectal
Legal status
Legal status	UK: POM (Prescription only) ; US: Not approved for use or sale; Prescription medicine (Rx only):Pakistan, India, Australia, Canada, Israel, Belgium, France, Netherlands; over-the-counter: Egypt, Ireland, Italy, Japan, South Africa, Switzerland, Kuwait, China, Russia, Slovakia, Ukraine Mexico, Thailand, Malta, South Korea, and Romania;
Pharmacokinetic data
Bioavailability	By mouth: 13–17%; Intramuscular: 90%
Protein binding	~92%
Metabolism	Liver (CYP3A4/5) and intestinal (first-pass)
Metabolites	All inactive
Elimination half-life	7.5 hours
Excretion	Feces: 66%; Urine: 32%; Breast milk: small quantities
Identifiers
	IUPAC name 5-Chloro-1-(1-[3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl]piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one;
ECHA InfoCard	100.055.408
Chemical and physical data
Formula	C22H24ClN5O2
Molar mass	୪୨୫.୯୨ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	242.5 °C (468.5 °F)
	SMILES Clc1cc2c(cc1)N(C(=O)N2)C5CCN(CCCN4c3ccccc3NC4=O)CC5;
	InChI InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) ; Key:FGXWKSZFVQUSTL-UHFFFAOYSA-N ;
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ଡମ‌ପେରିଡନ (ଇଂରାଜୀ ଭାଷାରେ Domperidone) ବିକ୍ରୟ ନାମ ମୋଟିଲିଅମ (Motilium) ଏକ ଔଷଧ ଯାହା ଅଇ, ପାକସ୍ଥଳୀ ମାଧ୍ୟମରେ ଖାଦ୍ୟର ପରିବ‌ହନ ବୃଦ୍ଧି, ଅଧକପାଳି ଚିକିତ୍ସା, ଏବଂ ସ୍ତନ ଦୁଗ୍ଧ ପରିମାଣ ବୃଦ୍ଧି କରିବା ନିମନ୍ତ ଦିଆଯାଏ । ^[୧] ^[୬] ^[୭] ଏହା ପାଟିଦ୍ୱାରା ନିଆଯାଏ | ^[୮] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାର ବିପଦ ହେତୁ ଏକ ସପ୍ତାହରୁ କମ୍ ସମୟ ପାଇଁ ବ୍ୟବହାର କରିବାକୁ ସୁପାରିଶ କରାଯାଏ ଏବଂ ସ୍ତନ୍ୟପାନ ବୃଦ୍ଧି କରିବାକୁ ପରାମର୍ଶ ଦିଆଯାଇନଥାଏ | ^[୯]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୁଖିଲା ପାଟି ଅନ୍ତର୍ଭୁକ୍ତ | ^[୯] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଦ୍‌ବେଗ, ତରଳ ଝାଡ଼ା ଏବଂ ଯୌନ‌କ୍ରିୟା ଅସୁବିଧା ହୋଇପାରେ | ^[୯] ଅନିୟମିତ ହୃତ୍ ସ୍ପନ୍ଦନ ଏବଂ ହଠାତ୍ ହୃଦ୍‌‌ରୋଧ ହେବାର ଆଶଙ୍କା ଥିବାରୁ ହୃଦ୍‌ରୋଗରେ ଏହାର ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ। ^[୯] ^[୧୦] ସ୍ତନ୍ୟପାନ ସମୟରେ ବ୍ୟବହାର ଶିଶୁ ପାଇଁ ସୁରକ୍ଷିତ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ | ^[୯] ^[୧୧] ଡମ‌ପେରିଡନ ହେଉଛି ଏକ ପାରିପାର୍ଶ୍ୱିକ ଚୟନ‌କାରୀ ଡୋପାମାଇନ୍ ଡି୨ ରିସେପ୍ଟର ବିରୋଧୀ ଔଷଧ | ^[୧]

୧୯୭୪ ମସିହାରେ ଜନସେନ ଫାର୍ମାସିଉଟିକା ଏହାକୁ ବିକଶିତ କରିଥିଲେ | ^[୧୨] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୯] ଯୁକ୍ତରାଜ୍ୟରେ ଏନଏଚଏସ (NHS)ର ଯୋଗାଣ ବାବଦ ପ୍ରାୟ ୩ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ | ^[୯] ଅନେକ ଦେଶରେ ଉପଲବ୍ଧ ଥିବାବେଳେ ଏହା କେବଳ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଗୁରୁତର ପାକସ୍ଥଳୀ-ଅନ୍ତନାଳୀ ଗତିଶୀଳତା ବ୍ୟାଧି ପାଇଁ ବ୍ୟବ‌ହାର କରାଯାଏ ଯାହା ଅନ୍ୟ କୌଣସି ଚିକିତ୍ସାର ଉପଶନ ହୋଇନଥାଏ | ^[୧] ^[୧୩]

ଆଧାର

↑ ^୧.୦୦ ^୧.୦୧ ^୧.୦୨ ^୧.୦୩ ^୧.୦୪ ^୧.୦୫ ^୧.୦୬ ^୧.୦୭ ^୧.୦୮ ^୧.୦୯ ^୧.୧୦ ^୧.୧୧ ^୧.୧୨ Reddymasu, Savio C.; Soykan, Irfan; McCallum, Richard W. (2007). "Domperidone: Review of Pharmacology and Clinical Applications in Gastroenterology". The American Journal of Gastroenterology. 102 (9): 2036–2045. ISSN 0002-9270. PMID 17488253.
↑ "БРЮЛІУМ ЛІНГВАТАБС" [BRULIUM LINGUATABS]. Нормативно-директивні документи МОЗ України (in ୟୁକ୍ରାନିଆନ୍). 2014-03-18. Retrieved 2015-05-29.
↑ "Domperidone". Archived from the original on 22 ମଇ 2013. Retrieved 30 ଜୁନ 2013.
↑ ^୪.୦ ^୪.୧ Simard, C.; Michaud, V.; Gibbs, B.; Massé, R.; Lessard, É; Turgeon, J. (2008). "Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone". Xenobiotica. 34 (11–12): 1013–1023. doi:10.1080/00498250400015301. ISSN 0049-8254. PMID 15801545. S2CID 27426219.
↑ ^୫.୦ ^୫.୧ Suzanne Rose (October 2004). Gastrointestinal and Hepatobiliary Pathophysiology. Hayes Barton Press. pp. 523–. ISBN 978-1-59377-181-2.^{[permanent dead link]}
↑ Paul, C; Zénut, M; Dorut, A; Coudoré, MA; Vein, J; Cardot, JM; Balayssac, D (February 2015). "Use of domperidone as a galactagogue drug: a systematic review of the benefit-risk ratio". Journal of human lactation : official journal of International Lactation Consultant Association. 31 (1): 57–63. doi:10.1177/0890334414561265. PMID 25475074.
↑ Becker, WJ (June 2015). "Acute Migraine Treatment in Adults". Headache. 55 (6): 778–93. doi:10.1111/head.12550. PMID 25877672.
↑ BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 444. ISBN 9780857113658.
↑ ^୯.୦ ^୯.୧ ^୯.୨ ^୯.୩ ^୯.୪ ^୯.୫ ^୯.୬ BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 444. ISBN 9780857113658.
↑ Leelakanok, N; Holcombe, A; Schweizer, ML (February 2016). "Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis". Clinical drug investigation. 36 (2): 97–107. doi:10.1007/s40261-015-0360-0. PMID 26649742.
↑ "Domperidone". Drugs and Lactation Database (LactMed). National Library of Medicine (US). Retrieved 6 October 2020.
↑ Zarros, Apostolos; Tansey, Tilli (2019). Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals (in ଇଂରାଜୀ). Frontiers Media SA. p. 49. ISBN 978-2-88963-223-7.
↑ Research, Center for Drug Evaluation and (3 August 2020). "How to Request Domperidone for Expanded Access Use". FDA (in ଇଂରାଜୀ). Retrieved 6 October 2020.

[Red2007-1] ୧.୦୦ ^୧.୦୧ ^୧.୦୨ ^୧.୦୩ ^୧.୦୪ ^୧.୦୫ ^୧.୦୬ ^୧.୦୭ ^୧.୦୮ ^୧.୦୯ ^୧.୧୦ ^୧.୧୧ ^୧.୧୨ Reddymasu, Savio C.; Soykan, Irfan; McCallum, Richard W. (2007). "Domperidone: Review of Pharmacology and Clinical Applications in Gastroenterology". The American Journal of Gastroenterology. 102 (9): 2036–2045. ISSN 0002-9270. PMID 17488253.

[2] "БРЮЛІУМ ЛІНГВАТАБС" [BRULIUM LINGUATABS]. Нормативно-директивні документи МОЗ України (in ୟୁକ୍ରାନିଆନ୍). 2014-03-18. Retrieved 2015-05-29.

[3] "Domperidone". Archived from the original on 22 ମଇ 2013. Retrieved 30 ଜୁନ 2013.

[SimardMichaud2008-4] ୪.୦ ^୪.୧ Simard, C.; Michaud, V.; Gibbs, B.; Massé, R.; Lessard, É; Turgeon, J. (2008). "Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone". Xenobiotica. 34 (11–12): 1013–1023. doi:10.1080/00498250400015301. ISSN 0049-8254. PMID 15801545. S2CID 27426219.

[Rose2004-5] ୫.୦ ^୫.୧ Suzanne Rose (October 2004). Gastrointestinal and Hepatobiliary Pathophysiology. Hayes Barton Press. pp. 523–. ISBN 978-1-59377-181-2.^{[permanent dead link]}

[Breast2015-6] Paul, C; Zénut, M; Dorut, A; Coudoré, MA; Vein, J; Cardot, JM; Balayssac, D (February 2015). "Use of domperidone as a galactagogue drug: a systematic review of the benefit-risk ratio". Journal of human lactation : official journal of International Lactation Consultant Association. 31 (1): 57–63. doi:10.1177/0890334414561265. PMID 25475074.

[7] Becker, WJ (June 2015). "Acute Migraine Treatment in Adults". Headache. 55 (6): 778–93. doi:10.1111/head.12550. PMID 25877672.

[BNF79-8] BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 444. ISBN 9780857113658.

[autogen1-9] ୯.୦ ^୯.୧ ^୯.୨ ^୯.୩ ^୯.୪ ^୯.୫ ^୯.୬ BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 444. ISBN 9780857113658.

[Lee2016-10] Leelakanok, N; Holcombe, A; Schweizer, ML (February 2016). "Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis". Clinical drug investigation. 36 (2): 97–107. doi:10.1007/s40261-015-0360-0. PMID 26649742.

[11] "Domperidone". Drugs and Lactation Database (LactMed). National Library of Medicine (US). Retrieved 6 October 2020.

[12] Zarros, Apostolos; Tansey, Tilli (2019). Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals (in ଇଂରାଜୀ). Frontiers Media SA. p. 49. ISBN 978-2-88963-223-7.

[FDA2020-13] Research, Center for Drug Evaluation and (3 August 2020). "How to Request Domperidone for Expanded Access Use". FDA (in ଇଂରାଜୀ). Retrieved 6 October 2020.

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