ସାକୁବିଟ୍ରିଲ/ଭାଲ୍‌ସାର୍ଟାନ

ସାକୁବିଟ୍ରିଲ/ଭାଲ୍‌ସାର୍ଟାନ
Combination of
Sacubitril	Neprilysin inhibitor
Valsartan	Angiotensin II receptor antagonist
Clinical data
Trade names	Entresto, Azmarda, Neparvis, others
Synonyms	LCZ696
AHFS/Drugs.com	monograph
MedlinePlus	a615039
data	EU EMA: yes; US DailyMed: Sacubitril_and_valsartan;
Pregnancy; category	AU: D ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Chemical and physical data
Formula	C96H120N12Na6O21
Molar mass	୧,୯୧୬.୦୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[N-]3)C(C(C)C)C(=O)[O-].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[N-]3)C(C(C)C)C(=O)[O-].CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+];
	InChI InChI=1S/2C24H29N5O3.2C24H29NO5.6Na.5H2O/c21-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23;21-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;;;;;;;;;;;/h26-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H2,25,26,27,28,31,32);24-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);;;;;;;51H2/q;;;;6+1;;;;;/p-6/t222-;217-,21+;;;;;;;;;;;/m0011.........../s1; Key:ZASXKEGREHRXDL-CAWNUZPDSA-H;

ସାକୁବିଟ୍ରିଲ/ଭାଲ୍‌ସାର୍ଟାନ, ବିକ୍ରୟ ନାମ ଏଣ୍ଟ୍ରେସ୍ଟୋ, ହେଉଛି ଏକ ଔଷଧ ମିଶ୍ରଣ ଯାହା ହ୍ରାସକୃତ ଇଜେକସନ ଭଗ୍ନାଂଶ ସହିତ ଥିବା ହୃଦ୍‌ପାତ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୭] ଏହା ଆଞ୍ଜିଓଟେନସିନ୍-ରୂପାନ୍ତରକାରୀ-ଏନଜାଇମ ଅବରୋଧକ ବା ଏସିଇ ଇନହିବିଟର ବଦଳରେ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୭] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୭]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତଚାପ, କାଶ, ବୃକ୍‌କ ସମସ୍ୟା ଏବଂ ଉଚ୍ଚ ପୋଟାସିୟମ୍ ହୋଇପାରେ ।^[୮] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଞ୍ଜିଓଇଡିମା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୮] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ ।^[୮] ଏଥିରେ ସାକୁବିଟ୍ରିଲ୍ ନାମକ ଏକ ନେପ୍ରିଲିସିନ୍ ଇନହିବିଟର ଏବଂ ଭାଲସାର୍ଟାନ୍ ନାମକ ଏକ ଆଞ୍ଜିଓଟେନସିନ୍ ରିସେପ୍ଟର ବ୍ଲକର୍ ଥାଏ ।^[୮] ଏହି ମିଶ୍ରଣ ବେଳେବେଳେ ଏକ "ଆଞ୍ଜିଓଟେନସିନ୍ ରିସେପ୍ଟର-ନେପ୍ରିଲିସିନ୍ ଇନହିବିଟର" (ARNi) ଭାବରେ ଜଣାଶୁଣା ଥାଏ ।^[୮]

୨୦୧୫ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଏହି ଔଷଧ ମିଶ୍ରଣ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩]^[୮] ଏହା ୨୦୧୬ ମସିହାରେ ଅଷ୍ଟ୍ରେଲିଆରେ ଏହା ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ମସିହାରେ ଏହାର ଏକ ମାସ ଔଷଧର ଖର୍ଚ୍ଚ ୫୭୫ ଡଲାର ଥିଲା ।^[୯] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ରାଶିର ମୂଲ୍ୟ ୯୨ ପାଉଣ୍ଡ ଥିଲା ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Entresto 24/26 tablets, Entresto 49/51 tablets, Entresto 97/103 tablets (sacubitril/valsartan) Product Information". Therapeutic Goods Administration (TGA). Novartis. Archived from the original on 11 November 2020. Retrieved 21 September 2020.
↑ "Sacubitril / valsartan (Entresto) Use During Pregnancy". Drugs.com. 20 November 2019. Archived from the original on 17 April 2021. Retrieved 21 September 2020.
↑ ^୩.୦ ^୩.୧ "Entresto EPAR". European Medicines Agency (EMA). Archived from the original on 27 February 2021. Retrieved 21 September 2020.
↑ "Neparvis EPAR". European Medicines Agency (EMA). Archived from the original on 28 December 2020. Retrieved 23 September 2020.
↑ "Entresto 24 mg/26 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 24 January 2021. Retrieved 21 September 2020.
↑ "Entresto- sacubitril and valsartan tablet, film coated". DailyMed. 14 June 2020. Archived from the original on 19 April 2020. Retrieved 21 September 2020.
↑ ^୭.୦ ^୭.୧ ^୭.୨ ^୭.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 207. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ ^୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ "Sacubitril and Valsartan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 January 2020. Retrieved 9 October 2021.
↑ "Entresto Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 9 October 2021.

[AUPI-1] ୧.୦ ^୧.୧ ^୧.୨ "Entresto 24/26 tablets, Entresto 49/51 tablets, Entresto 97/103 tablets (sacubitril/valsartan) Product Information". Therapeutic Goods Administration (TGA). Novartis. Archived from the original on 11 November 2020. Retrieved 21 September 2020.

[Drugs.com_pregnancy-2] "Sacubitril / valsartan (Entresto) Use During Pregnancy". Drugs.com. 20 November 2019. Archived from the original on 17 April 2021. Retrieved 21 September 2020.

[EPAR2021-3] ୩.୦ ^୩.୧ "Entresto EPAR". European Medicines Agency (EMA). Archived from the original on 27 February 2021. Retrieved 21 September 2020.

[Neparvis_EPAR-4] "Neparvis EPAR". European Medicines Agency (EMA). Archived from the original on 28 December 2020. Retrieved 23 September 2020.

[5] "Entresto 24 mg/26 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 24 January 2021. Retrieved 21 September 2020.

[Entresto_FDA_label-6] "Entresto- sacubitril and valsartan tablet, film coated". DailyMed. 14 June 2020. Archived from the original on 19 April 2020. Retrieved 21 September 2020.

[BNF80-7] ୭.୦ ^୭.୧ ^୭.୨ ^୭.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 207. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHFS2021-8] ୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ "Sacubitril and Valsartan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 January 2020. Retrieved 9 October 2021.

[9] "Entresto Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 9 October 2021.

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