ଲୋରାଟାଡାଇନ

ଲୋରାଟାଡାଇନ
Clinical data
Trade names	Claritin, Claratyne, Clarityn, others
AHFS/Drugs.com	monograph
MedlinePlus	a697038
data	US DailyMed: Loratadine;
Pregnancy; category	AU: B1 ;
Routes of; administration	By mouth
Drug class	Second-generation antihistamine
ATC code	R06AX13 (WHO) ;
Legal status
Legal status	CA: OTC [ଆଧାର ଲୋଡ଼ା]; UK: General sales list (GSL, OTC) / Pharmacy; US: OTC / Rx-only;
Pharmacokinetic data
Bioavailability	almost 100%
Protein binding	97–99%
Metabolism	liver (CYP2D6- and 3A4-mediated)
Elimination half-life	8 hours, active metabolite desloratadine 27 hours
Excretion	40% as conjugated metabolites into urine; Similar amount into the feces
Identifiers
	IUPAC name Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate;
CAS Number	79794-75-5 ;
PubChem CID	3957;
IUPHAR/BPS	7216;
DrugBank	DB00455 ;
ChemSpider	3820 ;
UNII	7AJO3BO7QN;
KEGG	D00364 ;
ChEBI	CHEBI:6538 ;
ChEMBL	CHEMBL998 ;
ECHA InfoCard	100.120.122
Chemical and physical data
Formula	C22H23ClN2O2
Molar mass	୩୮୨.୮୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)N4CC/C(=C2/c1ccc(Cl)cc1CCc3cccnc23)CC4;
	InChI InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3 ; Key:JCCNYMKQOSZNPW-UHFFFAOYSA-N ;
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ଲୋରାଟାଡାଇନ, ଏକ ପ୍ରକାର ବ୍ରାଣ୍ଡ ନାମ କ୍ଲାରିଟିନ୍, ଏକ ଔଷଧ ଯାହା ଆଲର୍ଜି ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୩] ଏହା ଆଲର୍ଜିକ ନାକ ପ୍ରଦାହ ଏବଂ ହାଇଭ୍‌ସ ନିମନ୍ତେ ମଧ୍ୟ ଦିଆଯାଏ | ^[୪] ଏକ ଡିକଞ୍ଜେଷ୍ଟାଣ୍ଟ ସୁଡୋଏଫିଡ୍ରନ ସହିତ ମିଳିତ ଭାବରେ ଉପଲବ୍ଧ ଯାହା ଲୋରାଟାଡାଇନ/ସୁଡୋଏଫିଡ୍ରନ ନାମରେ ବିକ୍ରି ହୁଏ । ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ, ଶୁଖିଲା ପାଟି ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ଅନ୍ତର୍ଭୁକ୍ତ | ^[୩] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ବିରଳ ଥାଏ ଏବଂ ଏଥିରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା, ବାତ ଏବଂ ଯକୃତ ସମସ୍ୟା ଉତ୍ପନ୍ନ ହୋଇପାରେ | ^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ନିରାପଦ ମନେହୁଏ କିନ୍ତୁ ଏହାର ଅଧିକ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ | ^[୬] ଦୁଇ ବର୍ଷରୁ କମ୍ ପିଲାମାନଙ୍କଠାରେ ଏହା ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୭] ଏହା ଦ୍ୱିତୀୟ ପିଢ଼ୀ ଆଣ୍ଟିହିଷ୍ଟାମିନ ଔଷଧ ପରିବାରରେ ଅଛି | ^[୪]

ଲୋରାଟାଡାଇନ ୧୯୮୦ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇ ୧୯୮୮ରେ ବଜାରରେ ମିଳିଲା ^[୮] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ତାଲିକାରେ ଲିପିବଦ୍ଧ ଅଛି ।^[୯]ଏହା ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୩] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ ୨୦୧୫ ମସିହାର ଏହାର ହୋଲସେଲ୍ ମୂଲ୍ୟ ୦।୦୧-୦।୦୬ ଡଲାର ଥିଲା ।^[୧୦] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ବିନା ପ୍ରେସକ୍ରିପସନରେ ଉପଲବ୍ଧ | ^[୪] ୨୦୧୭ ମସିହାରେ ଏହା ଆମେରିକାରେ ୫୯ତମ ସାଧାରଣ ଔଷଧ ଥିଲା, ଯାହାର ବାର ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା। ^[୧୧] ^[୧୨]

ଆଧାର

↑ "Loratadine Use During Pregnancy". Drugs.com. 10 February 2020. Retrieved 10 April 2020.
↑ "Clarityn Allergy 10mg Tablets (P & GSL) - Patient Information Leaflet (PIL)". (emc). 30 August 2019. Archived from the original on 10 April 2020. Retrieved 10 April 2020.
1 2 3 "Loratadine". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
1 2 3 4 5 "Loratadine". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
↑ "Clarityn Allergy 10mg Tablets (P) - Summary of Product Characteristics (SmPC) - (eMC)". www.medicines.org.uk. 7 October 2015. Archived from the original on 20 December 2016. Retrieved 13 December 2016.
↑ "Loratadine Use During Pregnancy". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 13 December 2016.
↑ "Clarityn Allergy 10mg Tablets (P) - Summary of Product Characteristics (SmPC) - (eMC)". www.medicines.org.uk. 7 October 2015. Archived from the original on 20 December 2016. Retrieved 13 December 2016.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495.
↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
↑ "Loratadine". International Drug Price Indicator Guide. Archived from the original on 1 August 2018. Retrieved 1 June 2018.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Loratadine - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

[Drugs.com_pregnancy-1] "Loratadine Use During Pregnancy". Drugs.com. 10 February 2020. Retrieved 10 April 2020.

[2] "Clarityn Allergy 10mg Tablets (P & GSL) - Patient Information Leaflet (PIL)". (emc). 30 August 2019. Archived from the original on 10 April 2020. Retrieved 10 April 2020.

[AHFS2016-3] 1 2 3 "Loratadine". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.

[autogen1-4] 1 2 3 4 5 "Loratadine". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.

[ERC2015-5] "Clarityn Allergy 10mg Tablets (P) - Summary of Product Characteristics (SmPC) - (eMC)". www.medicines.org.uk. 7 October 2015. Archived from the original on 20 December 2016. Retrieved 13 December 2016.

[6] "Loratadine Use During Pregnancy". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 13 December 2016.

[autogen3-7] "Clarityn Allergy 10mg Tablets (P) - Summary of Product Characteristics (SmPC) - (eMC)". www.medicines.org.uk. 7 October 2015. Archived from the original on 20 December 2016. Retrieved 13 December 2016.

[Fis2006-8] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495.

[WHO21st-9] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[ERC2014-10] "Loratadine". International Drug Price Indicator Guide. Archived from the original on 1 August 2018. Retrieved 1 June 2018.

[ref-11] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ref1-12] "Loratadine - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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