ଡେସ୍ଲୋରାଟାଡାଇନ

ଡେସ୍ଲୋରାଟାଡାଇନ
Clinical data
Trade names	Aerius, Allex, Clarinex, others
AHFS/Drugs.com	monograph
MedlinePlus	a602002
data	EU EMA: yes; US DailyMed: Desloratadine;
Pregnancy; category	AU: B1 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth (tablets, solution)
Legal status
Legal status	AU: S2 (Pharmacy only) ; CA: OTC ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	Rapidly absorbed
Protein binding	83 to 87%
Metabolism	UGT2B10, CYP2C8
Metabolites	3-Hydroxydesloratadine
Onset of action	Within 1 hour
Elimination half-life	27 hours
Duration of action	Up to 24 hours
Excretion	40% as conjugated metabolites into urine; Similar amount into the feces
Identifiers
	IUPAC name 8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine;
ECHA InfoCard	100.166.554
Chemical and physical data
Formula	C19H19ClN2
Molar mass	୩୧୦.୮୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc4cc2c(C(/c1ncccc1CC2)=C3/CCNCC3)cc4;
	InChI InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 ; Key:JAUOIFJMECXRGI-UHFFFAOYSA-N ;
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ଡେସ୍ଲୋରାଟାଡାଇନ, ଏକ ବେପାର ନାମ କ୍ଲାରିନକ୍ସ, ଏକ ଔଷଧ ଯାହା ଅର୍ଟିକାରିଆ ଏବଂ ଆଲର୍ଜିକ ନାକ ପ୍ରଦାହ ଭଳି ଆଲର୍ଜି ସମ୍ପନ୍ନ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଏହି ଔଷଧର ପ୍ରଭାବ ଏଇ ଘଣ୍ଟାରେ ଆରମ୍ଭ ହୋଇ ୨୪ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହେ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ଥକାପଣ, ଶୁଖିଲା ପାଟି ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ ।^[୩] ବୃକ୍‌କ କିମ୍ବା ଯକୃତ ଜନିତ ସମସ୍ୟାରେ କମ ମାତ୍ରା ଦେବାକୁ ସୁପାରିଶ କରାଯାଏ ।^[୩] ଯଦିଓ ଗର୍ଭାବସ୍ଥାରେ କ୍ଷତିର କୌଣସି ସ୍ପଷ୍ଟ ପ୍ରମାଣ ନାହିଁ, ସାଧାରଣତଃ ଏହାର ବ୍ୟବହାର କରିବାକୁ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୪]^[୫] ଏହା ଏକ ଦ୍ୱିତୀୟ ପିଢ଼ିର ଆଣ୍ଟିହିଷ୍ଟାମିନ ଔଷଧ ।^[୩] ଏହା ଲୋରାଟାଡାଇନର ଏକ ସକ୍ରିୟ ମେଟାବୋଲାଇଟ ।^[୩]

୧୯୮୪ ମସିହାରେ ଡେସ୍ଲୋରାଟାଡାଇନ୍ ପେଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୨୦୦୧ରେ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା ।^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ଏବଂ ପ୍ରତି ମାସରେ ଏହା ବାବଦ ପ୍ରାୟ ୧.୫ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶି ପ୍ରାୟ ୧୭ ଡଲାର ଅଟେ ।^[୭] ଏହା ସୁଡୋଏଫେଡ୍ରିନ ସହିତ ଏକ ମିଶ୍ରଣ ଭାବରେ ମଧ୍ୟ ଉପଲବ୍ଧ ।^[୩]

ଆଧାର

↑ Murdoch, David; Goa, Karen L.; Keam, Susan J. (April 7, 2003). "Desloratadine: an update of its efficacy in the management of allergic disorders". Drugs. 63 (19): 2051–2077. doi:10.2165/00003495-200363190-00010. PMID 12962522.
↑ "Allex EPAR". European Medicines Agency (EMA). Archived from the original on 2020-12-27. Retrieved 2020-04-05.
↑ ^୩.୦୦ ^୩.୦୧ ^୩.୦୨ ^୩.୦୩ ^୩.୦୪ ^୩.୦୫ ^୩.୦୬ ^୩.୦୭ ^୩.୦୮ ^୩.୦୯ "Desloratadine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 2020-08-12. Retrieved 2021-07-16.
↑ ^୪.୦ ^୪.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 294. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Desloratadine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 6 May 2021. Retrieved 16 July 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495. Archived from the original on 2020-12-27. Retrieved 2020-05-09.
↑ "Desloratadine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 10 September 2016. Retrieved 16 July 2021.

[murdoch-1] Murdoch, David; Goa, Karen L.; Keam, Susan J. (April 7, 2003). "Desloratadine: an update of its efficacy in the management of allergic disorders". Drugs. 63 (19): 2051–2077. doi:10.2165/00003495-200363190-00010. PMID 12962522.

[Allex_EPAR-2] "Allex EPAR". European Medicines Agency (EMA). Archived from the original on 2020-12-27. Retrieved 2020-04-05.

[AHFS2021-3] ୩.୦୦ ^୩.୦୧ ^୩.୦୨ ^୩.୦୩ ^୩.୦୪ ^୩.୦୫ ^୩.୦୬ ^୩.୦୭ ^୩.୦୮ ^୩.୦୯ "Desloratadine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 2020-08-12. Retrieved 2021-07-16.

[BNF80-4] ୪.୦ ^୪.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 294. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[Preg2021-5] "Desloratadine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 6 May 2021. Retrieved 16 July 2021.

[Fis2006-6] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495. Archived from the original on 2020-12-27. Retrieved 2020-05-09.

[GX2021-7] "Desloratadine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 10 September 2016. Retrieved 16 July 2021.

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