ଫେଣ୍ଟାନିଲ

ଉଇକିପିଡ଼ିଆ ରୁ
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ଫେଣ୍ଟାନିଲ
Fentanyl2DCSD.svg
Fentanyl-xtal-3D-balls.png
Clinical data
Trade namesActiq, Duragesic, Fentora, others
AHFS/Drugs.commonograph
data
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Dependence
liability
Very high
Routes of
administration
Buccal, epidural, IM, IT, IV, sublingual, skin patch
Drug classOpioid
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability92% (transdermal)
89% (intranasal)
50% (buccal)
33% (ingestion)
Protein binding80–85%
Metabolismhepatic, primarily by CYP3A4
Onset of action5 minutes[୧]
Elimination half-lifeIV: 6 mins (T1/2 α)
1 hours (T1/2 β)
16 hours (T1/2 ɣ)
Intranasal: 6.5 hours
Transdermal: 20–27 hours[୨]
Sublingual/buccal (single dose): 2.6–13.5 hours[୨]
Duration of actionIV: 30–60 minutes[୧][୩]
ExcretionMostly urinary (metabolites, <10% unchanged drug)[୨]
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.006.468 Edit this at Wikidata
Chemical and physical data
FormulaC22H28N2O
Molar mass336.471 g/mol
3D model (JSmol)
Melting point୮୭.୫ °C (୧୮୯.୫ °F)
  (verify)

ଫେଣ୍ଟାନିଲ (ଇଂରାଜୀ ଭାଷାରେ Fentanyl, also spelled fentanil) ଏକ ଓପିଅଏଡ ଔଷଧ ଯାହା ଯନ୍ତ୍ରଣା ନିବାରକ ଔଷଧ (pain medication) ଭାବରେ ଓ ନିଶ୍ଚେତକ (anesthesia) ଦେବା ସମୟରେ ବ୍ୟବ‌ହୃତ ହୁଏ ।[୨] ବେନିୟମ ଭାବରେ ଫେଣ୍ଟାନିଲ ମଧ୍ୟ ତିଆରି ହୋଇ ଆମୋଦ‌ ଦାୟକ ଔଷଧ (recreational drug) ଭାବରେ ହିରୋଇନ (heroin) ବା କୋକେନ (cocaine) ସାଥୀରେ ବ୍ୟବ‌ହାର କରାଯାଏ ।[୪] ଏହାର ପ୍ରଭାବ ଶୀଘ୍ର ଆରମ୍ଭ ହୋଇ ୧/୨ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହେ ।[୨] ଏହି ଔଷଧ ପାଟିରେ, ଇଞ୍ଜେକସନ (injection) ଆକାରରେ ଚର୍ମରେ (patch on the skin) ବା ନାକ ସ୍ପ୍ରେ (nasal spray) ଆକାରରେ ଦିଆଯାଏ । [୨]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି (vomiting), କୋଷ୍ଠକାଠିନ୍ୟ, ଦ୍ୱନ୍ଦ୍ୱ, ହାଲୁସିନେସନ (hallucinations), ପ୍ରଶାନ୍ତି ଓ ଦୁର୍ବଳ ନିୟନ୍ତ୍ରଣ ଯୋଗୁ ଆଘାତ ପାଇବା ଆଦି ହୋଇପାରେ ।[୨][୫] ସାଂଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ଶ୍ୱାସକ୍ରିୟା (decreased breathing), ସେରୋଟୋନିନ ସିଣ୍ଡ୍ରୋମ (serotonin syndrome), ନିମ୍ନ ରକ୍ତଚାପ (low blood pressure), ନିଶାଗ୍ରସ୍ତ ଓ କୋମା (coma) ହୋଇପାରେ ।[୨][୫] ସନ ୨୦୧୬ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ମାତ୍ରାଧିକ ଫେଣ୍ଟାନିଲ ଓ ଫେଣ୍ଟାନିଲ ଅନାଲଗ (fentanyl analogues) ସେବନ ଯୋଗୁ ୨୦,୦୦୦ ଲୋକ ମୃତ୍ୟୁ ବରଣ କରିଥିଲେ ।[୬][୭] ଓପିଅଏଡ (μ-opioid) ରିସେପ୍ଟରକୁ ଉତ୍ତେଜିତ କରି ଫେଣ୍ଟାନିଲ କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ । [୨] ମର୍ଫିନ ଅପେକ୍ଷା ଫେଣ୍ଟାନିଲ ୧୦୦ ଗୁଣ ଓ କାର୍ଫେଣ୍ଟାନିଲ (‌carfentanil) ୧୦,୦୦୦ ଗୁଣ ଶକ୍ତିଶାଳୀ । [୮] }}

ଆଧାର[ସମ୍ପାଦନା]

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  2. ୨.୦ ୨.୧ ୨.୨ ୨.୩ ୨.୪ ୨.୫ ୨.୬ ୨.୭ ୨.୮ "Fentanyl, Fentanyl Citrate, Fentanyl Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 14 December 2017. Retrieved 8 December 2017.
  3. "Guideline for administration of fentanyl for pain relief in labour" (PDF). RCP. Archived (PDF) from the original on 4 March 2016. Retrieved 7 October 2015. Onset of action after IV administration of Fentanyl is 3–5 minutes; duration of action is 30–60 minutes.
  4. "Fentanyl Drug Overdose". CDC Injury Center (in ଇଂରାଜୀ). 29 August 2017. Archived from the original on 15 December 2017. Retrieved 14 December 2017.
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  6. "Overdose Death Rates". National Institute on Drug Abuse. 15 September 2017. Archived from the original on 13 December 2017. Retrieved 14 December 2017.
  7. "Nearly half of opioid-related overdose deaths involve fentanyl". National Institute on Drug Abuse. 2018-05-01. Archived from the original on 2018-06-14. Retrieved 2018-06-14.
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