ନର୍ଜେଷ୍ଟ୍ରେଲ୍

ନର୍ଜେଷ୍ଟ୍ରେଲ୍
	Top, levonorgestrel (CAS 797-63-7 ); ; Bottom: dextronorgestrel (CAS 797-64-8 ).
Clinical data
Trade names	Ovral, Opill, others
Synonyms	dl-Norgestrel; DL-Norgestrel; (±)-Norgestrel; WY-3707; SH-70850; SH-850; FH 122-A; rac-13-Ethyl-17α-ethynyl-19-nortestosterone; rac-13-Ethyl-17α-ethynylestr-4-en-17β-ol-3-one
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a602008
data	US DailyMed: Norgestrel;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only / OTC;
Identifiers
	IUPAC name (8R,9S,10R,13S,14S)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;
ECHA InfoCard	100.026.758
Chemical and physical data
Formula	C21H28O2
Molar mass	୩୧୨.୪୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C\1CC[C@H]4C(=C/1)/CC[C@@H]3[C@@H]4CC[C@@]2(CC)[C@H]3CCC2(O)C#C;
	InChI InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21?/m0/s1 ; Key:WWYNJERNGUHSAO-CULCCENASA-N ;
(verify)

ନର୍ଜେଷ୍ଟ୍ରେଲ, (ଇଂରାଜୀ ଭାଷାରେ Norgestrel), ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏହାର ଏକ ବେପାର ନାମ ଓପିଲ, ହେଉଛି ଜନ୍ମ ନିୟନ୍ତ୍ରଣ ବଟିକା ଭାବରେ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୨] ଉପଯୁକ୍ତ ବ୍ୟବହାର ସହିତ ପ୍ରାୟ ୨% ମହିଳା ପ୍ରତିବର୍ଷ ଗର୍ଭବତୀ ହୁଅନ୍ତି; ଯଦିଓ ସାଧାରଣ ବ୍ୟବହାର ସହିତ ଏହା ୮% ପାଖାପାଖି ଗର୍ଭବତୀ ହୋଇପାରନ୍ତି ।| ^[୨] ^[୩] ଏହା ହରମୋନ ପ୍ରତିସ୍ଥାପନ ଚିକିତ୍ସାର ଏକ ଅଂଶ ଭାବରେ ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୪] ଏହାକୁ ପ୍ରତିଦିନ ସମାନ ସମୟରେ ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅନିୟମିତ ଋତୁସ୍ରାବ, ମୁଣ୍ଡବିନ୍ଧା, ବାନ୍ତି, ଏବଂ ସ୍ତନ ଦରଜ ହୋଇପାରେ ।^[୩] ^[୫] ଏହା ଏଚଆଇଭି ସ‌ହିତ ଯୌନ କ୍ରିୟା ସଞ୍ଚାରିତ ରୋଗ ସମୂହକୁ ସୁରକ୍ଷା ଦିଏ ନାହିଁ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁକୁ କ୍ଷତି ପହଞ୍ଚାଇବା ପରି ଦେଖାଯାଏ ନାହିଁ ଏବଂ ସ୍ତନ୍ୟପାନ ସମୟରେ ମଧ୍ୟ ବ୍ୟବହାର ନିରାପଦ ଅଟେ ।^[୩] ବାତ ନିରୋଧକ ଔଷଧ ସମେତ କେତେକ ଔଷଧ ଏହାର ଫଳପ୍ରଦତା ହ୍ରାସ କରିପାରେ ।^[୩] ଇଷ୍ଟ୍ରୋଜେନ ବିନା ନର୍ଗେଷ୍ଟ୍ରେଲ୍ କେବଳ ଏକ ପ୍ରୋଜେଷ୍ଟିନ୍।^[୩] ଏଥିରେ ସମାନ ପରିମାଣର ଲେଭୋନରଜେସ୍ଟ୍ରେଲ (LNG) ଦ୍ୱାରା ତିଆରି ହୁଏ ଯାହା କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ଏବଂ ନିଷ୍କ୍ରିୟ ଡି-ନର୍ଜେଷ୍ଟ୍ରେଲ (D-norgestrel) ଥାଏ ।^[୬]

୧୯୬୧ ମସିହାରେ ନର୍ଜେଷ୍ଟ୍ରେଲ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୬୬ ମସିହାରେ ଚିକିତ୍ସା ବ୍ୟବହାରରେ ଆସିଥିଲା ।^[୭] ଏହାକୁ ବ୍ୟାପକ ଭାବେ ବିକ୍ରି କରାଯାଉଛି ।^[୮] ୨୦୨୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ମାସିକ ୨୦ ଡଲାର ମୂଲ୍ୟରେ ଉପଲବ୍ଧ ହୁଏ ।^[୯] ଏହା ପୂର୍ବରୁ ଆମେରିକାରେ ଏକ ପ୍ରକାର ଇଷ୍ଟ୍ରୋଜେନ୍ ସହିତ ମିଶି ଉପଲବ୍ଧ ଥିଲା ଯାହାର ନାମ ଏଥିନିଲ ଏଷ୍ଟ୍ରାଡିଓଲ/<b id="mwEg">ନର୍ଜେଷ୍ଟ୍ରେଲ</b> ଥିଲା ।^[୧୦]

ଆଧାର

↑ "FDA Approves First Nonprescription Daily Oral Contraceptive". U.S. Food and Drug Administration (FDA) (Press release). 2023-07-13. Archived from the original on 2023-07-13. Retrieved 2023-07-13. This article incorporates text from this source, which is in the public domain.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "DailyMed - OPILL- norgestrel tablet". dailymed.nlm.nih.gov. Archived from the original on 11 March 2024. Retrieved 10 March 2024.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ Torro, J; Bhayani, A (January 2024). "Norgestrel 0.075 mg (Opill) for Contraception". American family physician. 109 (1): 90–91. PMID 38227882.
↑ "Hormone replacement therapy (HRT)". NICE. September 2020. Archived from the original on 11 March 2024. Retrieved 10 March 2024.
↑ Research, Center for Drug Evaluation and (2023-07-14). "Opill (0.075mg Oral Norgestrel Tablet) Information". FDA (in ଇଂରାଜୀ). Archived from the original on 2023-10-09. Retrieved 2023-11-11.
↑ Bińkowska, M; Woroń, J (June 2015). "Progestogens in menopausal hormone therapy". Przeglad menopauzalny = Menopause review. 14 (2): 134–43. doi:10.5114/pm.2015.52154. PMID 26327902.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 479. ISBN 9783527607495.
↑ "Norgestrel - brand name list from". Drugs.com. Archived from the original on 2021-01-09. Retrieved 2022-09-17.
↑ Belluck, Pam (4 March 2024). "First U.S. Over-the-Counter Birth Control Pill Will Be Available Soon". The New York Times. Archived from the original on 7 March 2024. Retrieved 9 March 2024.
↑ "Generic Lo/Ovral-28 Availability". Archived from the original on 2019-03-02. Retrieved 2018-03-10.

[FDA_PR_20230713-1] "FDA Approves First Nonprescription Daily Oral Contraceptive". U.S. Food and Drug Administration (FDA) (Press release). 2023-07-13. Archived from the original on 2023-07-13. Retrieved 2023-07-13. This article incorporates text from this source, which is in the public domain.

[PI2024-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "DailyMed - OPILL- norgestrel tablet". dailymed.nlm.nih.gov. Archived from the original on 11 March 2024. Retrieved 10 March 2024.

[Tor2024-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ Torro, J; Bhayani, A (January 2024). "Norgestrel 0.075 mg (Opill) for Contraception". American family physician. 109 (1): 90–91. PMID 38227882.

[4] "Hormone replacement therapy (HRT)". NICE. September 2020. Archived from the original on 11 March 2024. Retrieved 10 March 2024.

[FDA2024-5] Research, Center for Drug Evaluation and (2023-07-14). "Opill (0.075mg Oral Norgestrel Tablet) Information". FDA (in ଇଂରାଜୀ). Archived from the original on 2023-10-09. Retrieved 2023-11-11.

[6] Bińkowska, M; Woroń, J (June 2015). "Progestogens in menopausal hormone therapy". Przeglad menopauzalny = Menopause review. 14 (2): 134–43. doi:10.5114/pm.2015.52154. PMID 26327902.

[Fis2006-7] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 479. ISBN 9783527607495.

[Drugs.com-8] "Norgestrel - brand name list from". Drugs.com. Archived from the original on 2021-01-09. Retrieved 2022-09-17.

[NYT2024-9] Belluck, Pam (4 March 2024). "First U.S. Over-the-Counter Birth Control Pill Will Be Available Soon". The New York Times. Archived from the original on 7 March 2024. Retrieved 9 March 2024.

[Combo-10] "Generic Lo/Ovral-28 Availability". Archived from the original on 2019-03-02. Retrieved 2018-03-10.

[୧]

[୨]

[୩]

[୪]

[୫]

[୬]

[୭]

[୮]

[୯]

[୧୦]