କୋଟିଆପିନ

କୋଟିଆପିନ
Clinical data
Pronunciation	/kwɪˈtaɪ.əpiːn/ kwi-TY-ə-peen
Trade names	Seroquel, Temprolide, others
AHFS/Drugs.com	monograph
MedlinePlus	a698019
data	US FDA: Quetiapine;
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	by mouth
ATC code	N05AH04 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	100%
Protein binding	83%
Metabolism	Liver via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)
Elimination half-life	7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)
Excretion	Kidney (73%), faeces (20%)
Identifiers
	IUPAC name 2-(2-(4-Dibenzo[b,f][1,4]thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol;
CAS Number	111974-69-7 ;
PubChem CID	5002;
IUPHAR/BPS	50;
DrugBank	DB01224 ;
ChemSpider	4827 ;
UNII	BGL0JSY5SI;
KEGG	D08456 ;
ChEBI	CHEBI:8707 ;
ChEMBL	CHEMBL716 ;
ECHA InfoCard	100.131.193
Chemical and physical data
Formula	C21H25N3O2S
Molar mass	383.5099 g/mol
3D model (JSmol)	Interactive image;
Solubility in water	3.29 mg/mL (20 °C)
	SMILES N\1=C(\c3c(Sc2c/1cccc2)cccc3)N4CCN(CCOCCO)CC4;
	InChI InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2 ; Key:URKOMYMAXPYINW-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Quetiapine

କୋଟିଆପିନ (ଇଂରାଜୀ ଭାଷାରେ Quetiapine, ମାର୍କେଟ ନାମ ସେରୋକ୍ୱେଲ/ Seroquel) ଏକ ଅନିୟମିତ ଆଣ୍ଟିସାଇକୋଟିକ ଯାହା ସିଜୋଫ୍ରେନିଆ, ବାଇପୋଲାର ଡିଜଅଡର ଓ ପ୍ରମୁଖ ଅବସାଦ ବେମାରୀ ଆଦି ରୋଗମାନଙ୍କର ଚିକିତ୍ସାରେ ଦିଆଯାଏ ।^[୬]^[୭] ନିଦ୍ରା ଆଣିବା ନିମନ୍ତେ ବେଳେବେଳେ ଦିଆଗଲେ ମଧ୍ୟ ଏହାକୁ ଦେବାକୁ ସୁପାରିସ କରାଯାଏନାହିଁ ।^[୮] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୬]

ଏହାର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତନ୍ଦ୍ରା, କୋଷ୍ଠକାଠିନ୍ୟ, ଓଜନ ବୃଦ୍ଧି ଓ ଶୁଷ୍କ ପାଟି (dry mouth) ଇତ୍ୟାଦି ଦେଖାଯାଏ ।^[୬] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଠିଆ ହେଲେ ନିମ୍ନ ରକ୍ତଚାପ (low blood pressure with standing), ବାତ (seizures), ପ୍ରାୟାପିଜ୍ମ, ଅଧିକ ରକ୍ତ ଶର୍କରା (high blood sugar) ଓ ନିଉରୋଲେପ୍ଟିକ ମାଲିଗନାଣ୍ଟ ସିଣ୍ଡ୍ରୋମ (neuroleptic malignant syndrome) ଇତ୍ୟାଦି ଦେଖାଯାଏ ।^[୬] ଡିମେନ୍ସିଆ ରୋଗ ଥିବା ବୟସ୍କ ଲୋକଙ୍କୁ ଏହି ଔଷଧ ଦେଲେ ମୃତ୍ୟୁ ସମ୍ଭାବନା ବଢ଼ିଯାଏ ।^[୬] ଗର୍ଭାବସ୍ଥାର ଶେଷ ଭାଗରେ ଏହା ଦେଲେ ଜନ୍ମିତ ଶିଶୁର କିଛି ଦିନ ନିମନ୍ତେ ମୁଭମେଣ୍ଟ ଡିଜଅଡର (movement disorder) ହୋଇପାରେ ।^[୬] ସେରୋଟୋନିନ (serotonin) ଓ ଡୋପାମିନ ରିସେପ୍ଟରମାନଙ୍କୁ (dopamine receptors) ଅବରୋଧ କରି କୋଟିଆପିନ କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୬]

ସନ ୧୯୮୫ରେ କୋଟିଆପିନ ପ୍ରସ୍ତୁତ କରାଯାଇଥିଲା ଓ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସନ ୧୯୯୭ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୬]^[୯] ଏହାର ପେଟେଣ୍ଟ ସୁରକ୍ଷା ସନ ୨୦୧୨ରେ ସରିଗଲେ ମଧ୍ୟ ଏହାର ଦୀର୍ଘକାଳୀନ ସଂସ୍କରଣ ସନ ୨୦୧୭ ପର୍ଯ୍ୟନ୍ତ ରହିବ ।^[୧୦]୨୦୧୭ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ସ୍ୱଳ୍ପକାଳୀନ ସଂସ୍କରଣର ମାସିକ ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୧୨ ଆମେରିକୀୟ ଡଲାର ।^[୧୧] ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ ଏହାର ଏକ ମାସର ଖର୍ଚ୍ଚ ପ୍ରାୟ ୩.୧୯ ପାଉଣ୍ଡ । ^[୧୨]

ଆଧାର[ସମ୍ପାଦନା]

↑ Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman’s The Pharmacological Basis of Therapeutics (12th ed.). McGraw Hill Professional. ISBN 978-0071624428.
↑ ^୨.୦ ^୨.୧ "quetiapine (Rx) - Seroquel, Seroquel XR". Medscape Reference. WebMD. Retrieved 11 October 2013.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics". electronic Medicines Compendium. Sandoz. January 2013. Retrieved 20 October 2013.
↑ ^୪.୦ ^୪.୧ Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.
↑ "QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]". DailyMed. Ascend Laboratories, LLC. October 2013. Retrieved 26 November 2013.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ ^୬.୪ ^୬.୫ ^୬.୬ ^୬.୭ "Quetiapine Fumarate". The American Society of Health-System Pharmacists. Retrieved 26 March 2017.
↑ Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S (Dec 8, 2010). "Second-generation antipsychotics for major depressive disorder and dysthymia". The Cochrane Database of Systematic Reviews (12): CD008121. doi:10.1002/14651858.CD008121.pub2. PMID 21154393.
↑ James J. Gugger; Manouchkathe Cassagnol (2008). "Low-dose quetiapine is not a benign sedative-hypnotic agent". The American Journal on Addictions. 17 (5): 454–455. doi:10.1080/10550490802266185. PMID 18770092.
↑ Riedel, M; Müller, N; Strassnig, M; Spellmann, I; Severus, E; Möller, HJ (April 2007). "Quetiapine in the treatment of schizophrenia and related disorders". Neuropsychiatric disease and treatment. 3 (2): 219–35. PMID 19300555.
↑ AstraZeneca (2013). "Pioneering science, life-changing medicines". www.sec.gov. Retrieved 26 March 2017.
↑ "NADAC as of 2017-03-22". Centers for Medicare and Medicaid Services. Retrieved 26 March 2017.
↑ British national formulary : BNF 69 (69th ed.). British Medical Association. 2015. p. 245. ISBN 9780857111562.

[GG-1] Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman’s The Pharmacological Basis of Therapeutics (12th ed.). McGraw Hill Professional. ISBN 978-0071624428.

[Medscape-2] ୨.୦ ^୨.୧ "quetiapine (Rx) - Seroquel, Seroquel XR". Medscape Reference. WebMD. Retrieved 11 October 2013.

[EMC-3] ୩.୦ ^୩.୧ ^୩.୨ "Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics". electronic Medicines Compendium. Sandoz. January 2013. Retrieved 20 October 2013.

[DD-4] ୪.୦ ^୪.୧ Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.

[DM-5] "QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]". DailyMed. Ascend Laboratories, LLC. October 2013. Retrieved 26 November 2013.

[AHFS2017-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ ^୬.୪ ^୬.୫ ^୬.୬ ^୬.୭ "Quetiapine Fumarate". The American Society of Health-System Pharmacists. Retrieved 26 March 2017.

[Cochrane2010-7] Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S (Dec 8, 2010). "Second-generation antipsychotics for major depressive disorder and dysthymia". The Cochrane Database of Systematic Reviews (12): CD008121. doi:10.1002/14651858.CD008121.pub2. PMID 21154393.

[8] James J. Gugger; Manouchkathe Cassagnol (2008). "Low-dose quetiapine is not a benign sedative-hypnotic agent". The American Journal on Addictions. 17 (5): 454–455. doi:10.1080/10550490802266185. PMID 18770092.

[9] Riedel, M; Müller, N; Strassnig, M; Spellmann, I; Severus, E; Möller, HJ (April 2007). "Quetiapine in the treatment of schizophrenia and related disorders". Neuropsychiatric disease and treatment. 3 (2): 219–35. PMID 19300555.

[10] AstraZeneca (2013). "Pioneering science, life-changing medicines". www.sec.gov. Retrieved 26 March 2017.

[11] "NADAC as of 2017-03-22". Centers for Medicare and Medicaid Services. Retrieved 26 March 2017.

[BNF69-12] British national formulary : BNF 69 (69th ed.). British Medical Association. 2015. p. 245. ISBN 9780857111562.

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