ଓପିକାପୋନ

ଓପିକାପୋନ
Clinical data
Trade names	Ongentys
Synonyms	BIA 9-1067
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Opicapone;
Pregnancy; category	AU: B2 ; Not recommended;
Routes of; administration	By mouth (capsules)
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	~20%
Protein binding	99.9%
Metabolism	Mainly sulfation, also reduction, glucuronidation, methylation
Elimination half-life	0.7 to 3.2 hours
Duration of action	>24 hours
Excretion	Feces (67%), urine (13%)
Identifiers
	IUPAC name 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl)-1,2,4-oxadiazol-5-yl]-3-nitrobenzene-1,2-diol;
Chemical and physical data
Formula	C15H10Cl2N4O6
Molar mass	୪୧୩.୧୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C(=[N+](C(=C1Cl)C)[O-])Cl)C2=NOC(=N2)C3=CC(=C(C(=C3)O)O)[N+](=O)[O-];
	InChI InChI=InChI=1S/C15H10Cl2N4O6/c1-5-10(13(17)20(24)6(2)11(5)16)14-18-15(27-19-14)7-3-8(21(25)26)12(23)9(22)4-7/h3-4,22-23H,1-2H3; Key:ASOADIZOVZTJSR-UHFFFAOYSA-N;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Opicapone

ଓପିକାପୋନ (ଇଂରାଜୀ ଭାଷାରେ Opicapone), ଓଙ୍ଗିକାଣ୍ଟସ୍ ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ଏକ ଔଷଧ ଯାହା ପାର୍କିନ୍‌ସନ୍ ରୋଗ ପାଇଁ ଲେଭୋଡୋପା/କାର୍ବିଡୋପା ସହିତ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ^[୫] ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବରେ ଏହା ଲେଭୋଡୋପର ପୁର୍ବବର୍ତ୍ତୀ ମାତ୍ରା ଦେବା ପୂର୍ବରୁ ଚଳପ୍ରଚଳ (motor function) କାର୍ଯ୍ୟରେ ଅସ୍ଥିରତାର ପରିବର୍ତ୍ତନ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୬] ଉପକାରଗୁଡ଼ିକ ଏଣ୍ଟାକାପୋନ ସହିତ ସମାନ ।^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଗତି ନିୟନ୍ତ୍ରଣ କରିବାରେ ଅସୁବିଧା (ଡିସକାଇନେସିଆ) ଅନ୍ତର୍ଭୁକ୍ତ | ^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କୋଷ୍ଠକାଠିନ୍ୟ, ନିମ୍ନ ରକ୍ତଚାପ, ଓଜନ ହ୍ରାସ ଏବଂ ମାଂସପେଶୀ ଭାଙ୍ଗିବା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୫] ଏହା ଲେଭୋଡୋପାର ପ୍ରଭାବକୁ ବୃଦ୍ଧି କରିବା ଫଳରେ ମସ୍ତିଷ୍କର କିଛି ଅଂଶର ଗତି ଏବଂ ସମନ୍ୱୟକୁ ଡୋପାମିନ୍ ନିୟନ୍ତ୍ରଣ କରେ ।^[୨] ଲେଭୋଡୋପା ଭାଙ୍ଗିବାରେ ଜଡିତ କାଟେକୋଲ-ଓ-ମିଥାଇଲଟ୍ରାନ୍ସଫରେଜ ନାମକ ଏକ ଏନଜାଇମକୁ ଏହା ଅବରୋଧ କରିଥାଏ | ^[୨]

୨୦୧୬ ମସିହାରେ ୟୁରୋପରେ ଏବଂ ୨୦୨୦ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଓପିକାପୋ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଏକ ମାସର ଔଷଧର ମୂଲ୍ୟ ୯୪ ପାଉଣ୍ଡ ଥିଲା ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୬୩୦ ଡଲାର ଅଟେ ।^[୭]

ଆଧାର

↑ "Archive copy" (PDF). Archived (PDF) from the original on 13 June 2021. Retrieved 13 June 2021.{{cite web}}: CS1 maint: archived copy as title (link)
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Ongentys EPAR". European Medicines Agency. Archived from the original on 9 May 2020. Retrieved 28 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ "Ongentys 50 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 18 July 2019. Archived from the original on 4 June 2020. Retrieved 28 April 2020.
↑ "Ongentys- opicapone capsule". DailyMed. 24 April 2020. Archived from the original on 25 October 2021. Retrieved 30 September 2020.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ "Opicapone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 June 2020. Retrieved 8 November 2021.
↑ ^୬.୦ ^୬.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 433. ISBN 978-0857114105.
↑ "Ongentys Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 November 2021.

[1] "Archive copy" (PDF). Archived (PDF) from the original on 13 June 2021. Retrieved 13 June 2021.{{cite web}}: CS1 maint: archived copy as title (link)

[EPAR2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Ongentys EPAR". European Medicines Agency. Archived from the original on 9 May 2020. Retrieved 28 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[Ongentys_SmPC-3] "Ongentys 50 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 18 July 2019. Archived from the original on 4 June 2020. Retrieved 28 April 2020.

[Ongentys_FDA_label-4] "Ongentys- opicapone capsule". DailyMed. 24 April 2020. Archived from the original on 25 October 2021. Retrieved 30 September 2020.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ "Opicapone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 June 2020. Retrieved 8 November 2021.

[BNF81-6] ୬.୦ ^୬.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 433. ISBN 978-0857114105.

[7] "Ongentys Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 November 2021.

[୧]

[୩]

[୪]

[୨]

[୫]

[୬]

[୭]