ଅକ୍ସିବ୍ୟୁଟିନିନ

ଅକ୍ସିବ୍ୟୁଟିନିନ
Clinical data
Trade names	Ditropan, others
AHFS/Drugs.com	monograph
MedlinePlus	a682141
data	EU EMA: yes;
Pregnancy; category	AU: B1 ; US: B (No risk in non-human studies) ;
Routes of; administration	By mouth, transdermal gel, transdermal patch
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only and OTC;
Pharmacokinetic data
Protein binding	91–93%
Elimination half-life	12.4–13.2 hours
Identifiers
	IUPAC name 4-Diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylethanoate;
ECHA InfoCard	100.158.590
Chemical and physical data
Formula	C22H31NO3
Molar mass	୩୫୭.୪୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC#CCN(CC)CC)C(O)(c1ccccc1)C2CCCCC2;
	InChI InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3 ; Key:XIQVNETUBQGFHX-UHFFFAOYSA-N ;
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ଅକ୍ସିବ୍ୟୁଟିନିନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ବେପାର ନମ ଡିଟ୍ରୋପାନ, ଏକ ଔଷଧ ଯାହା ଅତି ସକ୍ରିୟ ମୂତ୍ରାଶୟ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୧] ଏହା ଟୋଲଟେରୋଡାଇନ ପରି କାମ କରେ | ^[୨] ପିଲାମାନଙ୍କରେ ଶଯ୍ୟା ଓଦା ପାଇଁ ଏହା ବ୍ୟବହୃତ ହେଉଥିବାବେଳେ, ଏହି ବ୍ୟବହାରକୁ ସମର୍ଥନ କରିବାର ବିଶେଷ ପ୍ରମାଣ ନାହିଁ | ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ କିମ୍ବା ଚର୍ମରେ ଲଗାଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୁଷ୍କ ପାଟି, ମୁଣ୍ଡ ବୁଲା, କୋଷ୍ଠକାଠିନ୍ୟ, ଶୋଇବାରେ ଅସୁବିଧା ଏବଂ ମୂତ୍ରାଙ୍ଗ ସଂକ୍ରମଣ ହୋଇପାରେ | ^[୧] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୂତ୍ରାଶୟ ଧାରଣ ଏବଂ ଅଂଶୁଘାତ ହେବାର ଆଶଙ୍କା ରହିପାରେ | ^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ନିରାପଦ ଦେଖାଯାଏ କିନ୍ତୁ ସ୍ତନ୍ୟପାନରେ ବ୍ୟବହାର ଅସ୍ପଷ୍ଟ ଥିବାବେଳେ ଭଲ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ | ^[୩] ଏହା ଏକ ଆଣ୍ଟିମସ୍କାରିନିକ୍ ଏବଂ କୋମଳ ମାଂସପେଶୀ ଉପରେ ଆସେଟିଲକୋଲିନର ପ୍ରଭାବକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ | ^[୨]

୧୯୭୫ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅକ୍ସିବ୍ୟୁଟିନିନ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୧] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ଯାହା ଶସ୍ତା ଅଟେ। ^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସ ଯୋଗାଣକୁ ୨୦୧୯ ସୁଦ୍ଧା ମାସକୁ ୩ ପାଉଣ୍ଡରୁ କମ୍ ଖର୍ଚ୍ଚ ହୋଇଥାଏ |^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୧୪ ଡଲାର ଅଟେ | ^[୬] ୨୦୧୭ରେ, ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୦୦ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ସାତ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୭] ^[୮]

ଆଧାର

1 2 3 "Oxybutynin Chloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 24 June 2019. Retrieved 3 March 2019.
1 2 3 4 5 "Oxybutynin Chloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 24 June 2019. Retrieved 3 March 2019.
↑ "Oxybutynin Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 6 March 2019. Retrieved 3 March 2019.
↑ Hitchings, Andrew; Lonsdale, Dagan; Burrage, Daniel; Baker, Emma (2019). The Top 100 Drugs: Clinical Pharmacology and Practical Prescribing (in ଇଂରାଜୀ) (2nd ed.). Elsevier. pp. 76–77. ISBN 978-0-7020-7442-4. Archived from the original on 2021-05-22. Retrieved 2021-11-09.
↑ British National Formulary: BNF 76 (76th ed.). Pharmaceutical Press. 2018. ISBN 9780857113382.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019. Archived 2019-03-06 at the Wayback Machine.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Oxybutynin - Drug Usage Statistics". ClinCalc. Archived from the original on 2 July 2020. Retrieved 11 April 2020.

[AHFS2019-1] 1 2 3 "Oxybutynin Chloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 24 June 2019. Retrieved 3 March 2019.

[autogen1-2] 1 2 3 4 5 "Oxybutynin Chloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 24 June 2019. Retrieved 3 March 2019.

[Preg2019-3] "Oxybutynin Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 6 March 2019. Retrieved 3 March 2019.

[Hitch2019-4] Hitchings, Andrew; Lonsdale, Dagan; Burrage, Daniel; Baker, Emma (2019). The Top 100 Drugs: Clinical Pharmacology and Practical Prescribing (in ଇଂରାଜୀ) (2nd ed.). Elsevier. pp. 76–77. ISBN 978-0-7020-7442-4. Archived from the original on 2021-05-22. Retrieved 2021-11-09.

[BNF76-5] British National Formulary: BNF 76 (76th ed.). Pharmaceutical Press. 2018. ISBN 9780857113382.

[NADAC2019-6] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019. Archived 2019-03-06 at the Wayback Machine.

[ref-7] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[ref1-8] "Oxybutynin - Drug Usage Statistics". ClinCalc. Archived from the original on 2 July 2020. Retrieved 11 April 2020.

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