ସେଲେଗିଲିନ

ସେଲେଗିଲିନ
Clinical data
Pronunciation	/səˈlɛdʒɪliːn/ sə-LEJ-i-leen
Trade names	Eldepryl, Jumex, Zelapar, Emsam, others
Synonyms	L-Deprenyl; (R)-(–)-N,α-Dimethyl-N-2-propynylphenethylamine; (R)-(–)-N-Methyl-N-2-propynylamphetamine; (R)-(–)-N-2-propynylmethamphetamine
AHFS/Drugs.com	monograph
MedlinePlus	a697046
data	US FDA: Selegiline;
Pregnancy; category	AU: B2 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth, skin (patch)
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	10% (by mouth), 73% (patch)
Protein binding	94%
Metabolism	Intestines and liver
Metabolites	N-Desmethylselegiline, levoamphetamine, levomethamphetamine
Elimination half-life	1.5–3.5 hours (oral), 18–25 hours (transdermal)
Excretion	Urine
Identifiers
	IUPAC name (R)-N-methyl-N-(1-pheny lpropan-2-yl)prop-3-yn-1-amine;
ECHA InfoCard	100.109.269
Chemical and physical data
Formula	C13H17N
Molar mass	187.281
3D model (JSmol)	Interactive image;
	SMILES C#CCN([C@@H](Cc1ccccc1)C)C;
	InChI InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1 ; Key:MEZLKOACVSPNER-GFCCVEGCSA-N ;
(verify)

ସେଲେଗିଲିନ, ବେପାର ନାମ ଏଲଡେପ୍ରିଲ୍, ଏକ ଔଷଧ ଯାହା ପାର୍କିନ୍‌ସନ୍ ରୋଗ ସ‌ହ ପାର୍କିନ୍‌ସୋନିଜ୍ମ ଏବଂ ପ୍ରମୁଖ ଅବସାଦ ବେମାରୀର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ^[୫] ^[୬] ଏହା ପାଟିରେ ଦିଆଯାଏ କିମ୍ବା ଚର୍ମରେ ଲଗାଯାଇଥିବା ପ୍ୟାଚ୍ ଭାବରେ ବ୍ୟବହୃତ ହୁଏ ।^[୫] ^[୬]

ଯେତେବେଳେ ପାଟିଦ୍ୱାରା ନିଆଗଲେ ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ମୁଣ୍ଡ ହାଲୁକା, ଶୁଖିଲା ପାଟି, ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ହାଲୁସିନେସନ୍ ହୋଇପାରେ ।^[୪] ପ୍ୟାଚ୍ ଭାବରେ ପ୍ରୟୋଗ କରାଗଲେ ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୋଇବା ସମସ୍ୟା, ରାସ ଏବଂ ନାକ ଭରି ରହିଥାଏ ।^[୬] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସେରୋଟୋନିନ୍ ସିଣ୍ଡ୍ରୋମ, ନିମ୍ନ ରକ୍ତଚାପ, ଜୁଆ ଖେଳିବାକୁ ଇଚ୍ଛା, ନ୍ୟୁରୋଲେପ୍ଟିକ୍ ମାଲିଗନାଣ୍ଟ ସିଣ୍ଡ୍ରୋମ ଏବଂ ହଠାତ୍ ଶୋଇବା ଆରମ୍ଭ ହୋଇପାରେ। ^[୪] ଏହା ନିମ୍ନ ମାତ୍ରାରେ ଏକ ମୋନୋଆମିନୋ ଅକ୍ସିଡେଜ୍ ବି ଇନହିବିଟର ହୋଇଥିବାବେଳେ ଅଧିକ ମାତ୍ରାରେ ଏହା ଏକ ମୋନୋଏମାଇନ୍ ଅକ୍ସିଡେଜ୍ ଏ ଇନହିବିଟର କାମ କରେ ।^[୫] ^[୪] ଏହା ଡୋପାମାଇନ୍ ଏବଂ ସେରୋଟୋନିନର ମସ୍ତିଷ୍କ ସ୍ତର ବୃଦ୍ଧି କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୬] ^[୪]

୧୯୮୯ ମସିହାରେ ସେଲେଗିଲିନ ଔଷଧ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ୧୦ ମିଗ୍ରା ୧୦୦ ବଟିକା ଔଷଧର ମୂଲ୍ୟ ୨୦୨୧ରେ £୩୨ ଥିଲା । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ମୂଲ୍ୟ ୧୩୦ ଡଲାର ଥିଲା ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏକ ମାସର ପ୍ୟାଚର ମୂଲ୍ୟ ପ୍ରାୟ ୧,୮୦୦ ଡଲାର ଥିଲା ।^[୮]

ଆଧାର

↑ "Selegiline". Drugs.com. Archived from the original on December 29, 2019. Retrieved February 7, 2016.
↑ "Archive copy". Archived from the original on April 16, 2015. Retrieved July 10, 2021.{{cite web}}: CS1 maint: archived copy as title (link)
↑ "Archive copy" (PDF). Archived (PDF) from the original on April 3, 2021. Retrieved July 10, 2021.{{cite web}}: CS1 maint: archived copy as title (link)
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Selegiline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on August 13, 2020. Retrieved 11 October 2021.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 447. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "EMSAM® (selegiline transdermal system)" (PDF). Archived from the original (PDF) on August 10, 2021. Retrieved 11 October 2021.
↑ "Selegiline Prices and Selegiline Coupons - GoodRx". GoodRx. Retrieved 11 October 2021.
↑ "Emsam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on November 15, 2016. Retrieved 11 October 2021.

[DrugNames-1] "Selegiline". Drugs.com. Archived from the original on December 29, 2019. Retrieved February 7, 2016.

[2] "Archive copy". Archived from the original on April 16, 2015. Retrieved July 10, 2021.{{cite web}}: CS1 maint: archived copy as title (link)

[3] "Archive copy" (PDF). Archived (PDF) from the original on April 3, 2021. Retrieved July 10, 2021.{{cite web}}: CS1 maint: archived copy as title (link)

[AHFS2021-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Selegiline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on August 13, 2020. Retrieved 11 October 2021.

[BNF80-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 447. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[PI2006Patch-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "EMSAM® (selegiline transdermal system)" (PDF). Archived from the original (PDF) on August 10, 2021. Retrieved 11 October 2021.

[7] "Selegiline Prices and Selegiline Coupons - GoodRx". GoodRx. Retrieved 11 October 2021.

[8] "Emsam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on November 15, 2016. Retrieved 11 October 2021.

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