କଲଚିସିନ

କଲଚିସିନ
Clinical data
Trade names	Colcrys, Mitigare, others
AHFS/Drugs.com	monograph
MedlinePlus	a682711
data	US DailyMed: Colchicine;
Pregnancy; category	AU: D ; ;
Routes of; administration	By mouth
ATC code	M04AC01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	45%
Protein binding	35-44%
Metabolism	Metabolism, partly by CYP3A4
Elimination half-life	26.6-31.2 hours
Excretion	Faeces (65%)
Identifiers
	IUPAC name N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide;
CAS Number	64-86-8 ;
PubChem CID	6167;
IUPHAR/BPS	2367;
DrugBank	DB01394 ;
ChemSpider	5933 ;
UNII	SML2Y3J35T;
KEGG	D00570 ;
ChEBI	CHEBI:27882 ;
ChEMBL	CHEMBL107 ;
ECHA InfoCard	100.000.544
Chemical and physical data
Formula	C22H25NO6
Molar mass	399.437
3D model (JSmol)	Interactive image;
	SMILES O=C(N[C@@H]3C\1=C\C(=O)C(\OC)=C/C=C/1c2c(cc(OC)c(OC)c2OC)CC3)C;
	InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 ; Key:IAKHMKGGTNLKSZ-INIZCTEOSA-N ;
(verify)

କଲଚିସିନ ଏକ ଔଷଧ ଯାହା ଗାଉଟ ଏବଂ ବେସେଟ ଡିଜିଜ ରୋଗମାନଙ୍କ ଚିକିତ୍ସାରେ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୧] ^[୨] ^[୩] ଗାଉଟ ରୋଗରେ ଏହାନନଷ୍ଟେରଏଡାଲ ଆଣ୍ଟି-ଇନଫ୍ଲାମେଟରୀ ଔଷଧ କିମ୍ବା ସ୍ଟିରଏଡ ଅପେକ୍ଷା କମ୍ ପସନ୍ଦ କରାଯାଏ | ^[୪] ଅନ୍ୟାନ୍ୟ ବ୍ୟବହାରରେ ପେରିକାର୍ଡାଇଟିସ୍ ଏବଂ ପାରିବାରିକ ଭୂମଧ୍ୟସାଗରୀୟ ଜ୍ୱର ରୋଗର ପ୍ରତିଷେଧ ଭାବରେ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୪] ^[୫] ଏହା ପାଟିଦ୍ୱାରା ନିଆଯାଏ | ^[୪]

ଅଧିକ ମାତ୍ରାରେ ଏହି ଔଷଧ ଦେଲେ ସାଧାରଣତଃ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପାକଅନ୍ତନଳୀ ସମସ୍ୟା ହୁଏ ।^[୬] ଗୁରୁତର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତ କଣିକା ପରିମାଣ କମିଯାଏ ଏବଂ ରାବଡୋମାୟୋଲାଇସିସ୍ ହୋଇପାରେ | ^[୪] ଗର୍ଭଧାରଣ ସମୟରେ ବ୍ୟବହାରର ନିରାପତ୍ତା ଅସ୍ପଷ୍ଟ ଥିବାବେଳେ ସ୍ତନ୍ୟପାନ ସମୟରେ ବ୍ୟବହାର ନିରାପଦ ଦେଖାଯାଏ | ^[୪] ^[୭] ଅତ୍ୟଧିକ ମାତ୍ରାରେ ମୃତ୍ୟୁ ହୋଇପାରେ। ^[୪] ଏକାଧିକ ପ୍ରଣାଳୀରେ ପ୍ରଦାହ ହ୍ରାସ କରି କଲଚିସିନ କାମ କରେ | ^[୮]

କଲଚିସିନ୍ ଖ୍ରୀଷ୍ଟପୂର୍ବ ୧୫୦୦ ମସିହାରୁ ଅଟମ କ୍ରୋକସ ଆକାରରେ ଗଣ୍ଠି ଫୁଲା ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୋଇଥିଲା | ^[୯] ୧୯୬୧ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ଏହାକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା । ^[୧୦] ଏହା ଯୁକ୍ତରାଜ୍ୟରେ ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ଓ ୨୦୧୯ ମସିହାରେ^[୧୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୨୫୨.୨୦ ଆମେରିକୀୟ ଡଲାର ଥିଲା । ^[୧୨] ୨୦୧୭ ମସିହାରେ, ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୧ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଦୁଇ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା। ^[୧୩] ^[୧୪]

ଆଧାର

↑ Shekelle PG, Newberry SJ, FitzGerald JD, Motala A, O'Hanlon CE, Tariq A, Okunogbe A, Han D, Shanman R (January 2017). "Management of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline". Annals of Internal Medicine. 166 (1): 37–51. doi:10.7326/M16-0461. PMID 27802478. {{cite journal}}: Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)
↑ "Colchicine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 27 March 2019.
↑ Schachner, Lawrence A.; Hansen, Ronald C. (2011). Pediatric Dermatology E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 177. ISBN 9780723436652.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Colchicine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 27 March 2019.
↑ Hutchison, Stuart J. (2009). Pericardial Diseases: Clinical Diagnostic Imaging Atlas with DVD (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 58. ISBN 9781416052746.
↑ "Colchicine for acute gout: updated information about dosing and drug interactions". National Prescribing Service, Australia. 14 May 2010. Archived from the original on 30 June 2012. Retrieved 14 May 2010.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1085–1086. ISBN 9780857113382.
↑ Dalbeth N, Lauterio TJ, Wolfe HR (October 2014). "Mechanism of action of colchicine in the treatment of gout". Clinical Therapeutics. 36 (10): 1465–79. doi:10.1016/j.clinthera.2014.07.017. PMID 25151572.
↑ Wall, Wilson John (2015). The Search for Human Chromosomes: A History of Discovery (in ଇଂରାଜୀ). Springer. p. 88. ISBN 9783319263366.
↑ "Colchicine capsule". DailyMed. Retrieved 27 March 2019.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1085–1086. ISBN 9780857113382.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Colchicine - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

[Ann2017-1] Shekelle PG, Newberry SJ, FitzGerald JD, Motala A, O'Hanlon CE, Tariq A, Okunogbe A, Han D, Shanman R (January 2017). "Management of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline". Annals of Internal Medicine. 166 (1): 37–51. doi:10.7326/M16-0461. PMID 27802478. {{cite journal}}: Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)

[AHFS2019-2] "Colchicine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 27 March 2019.

[3] Schachner, Lawrence A.; Hansen, Ronald C. (2011). Pediatric Dermatology E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 177. ISBN 9780723436652.

[autogen2-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Colchicine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 27 March 2019.

[5] Hutchison, Stuart J. (2009). Pericardial Diseases: Clinical Diagnostic Imaging Atlas with DVD (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 58. ISBN 9781416052746.

[NPS2010-6] "Colchicine for acute gout: updated information about dosing and drug interactions". National Prescribing Service, Australia. 14 May 2010. Archived from the original on 30 June 2012. Retrieved 14 May 2010.

[BNF76-7] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1085–1086. ISBN 9780857113382.

[Dal2014-8] Dalbeth N, Lauterio TJ, Wolfe HR (October 2014). "Mechanism of action of colchicine in the treatment of gout". Clinical Therapeutics. 36 (10): 1465–79. doi:10.1016/j.clinthera.2014.07.017. PMID 25151572.

[9] Wall, Wilson John (2015). The Search for Human Chromosomes: A History of Discovery (in ଇଂରାଜୀ). Springer. p. 88. ISBN 9783319263366.

[Daily2019-10] "Colchicine capsule". DailyMed. Retrieved 27 March 2019.

[autogen1-11] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1085–1086. ISBN 9780857113382.

[NADAC2019-12] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-13] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ref1-14] "Colchicine - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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