ଟେମୋଜୋଲୋମାଇଡ

ଟେମୋଜୋଲୋମାଇଡ
Clinical data
Trade names	Temodar, Temodal, Temcad, others
AHFS/Drugs.com	monograph
MedlinePlus	a601250
data	EU EMA: yes; US DailyMed: Temozolomide;
Pregnancy; category	AU: D ; US: D (Evidence of risk) ; ;
Routes of; administration	By mouth, intravenous
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	almost 100%
Protein binding	15% (10–20%)
Metabolism	hydrolysis
Metabolites	3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC, the active species); temozolomide acid
Elimination half-life	1.8 hours
Excretion	mainly kidney
Identifiers
	IUPAC name 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide;
ECHA InfoCard	100.158.652
Chemical and physical data
Formula	C6H6N6O2
Molar mass	୧୯୪.୧୫ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	212 °C (414 °F) (decomp.)
	SMILES O=C(c1ncn2C(=O)N(\N=N/c12)C)N;
	InChI InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13) ; Key:BPEGJWRSRHCHSN-UHFFFAOYSA-N ;
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ଟେମୋଜୋଲୋମାଇଡ ( ଟିଏମଜେଡ୍ ), ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଟେମୋଡର, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଗ୍ଲାୟୋବ୍ଲାଷ୍ଟୋମା ମଲ୍ଟିଫର୍ମ ଏବଂ ଆନାପ୍ଲାଷ୍ଟିକ ଆଷ୍ଟ୍ରୋସାଇଟୋମା ଭଳି ମସ୍ତିଷ୍କ ଅର୍ବୁଦମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଏହା ପାଟିରେ କିମ୍ବା ଧୀରେ ଧୀରେ ଏକ ଶିରାରେ ଇଞ୍ଜେକ୍ସନଦ୍ୱାରା ନିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ବାନ୍ତି, କୋଷ୍ଠକାଠିନ୍ୟ, ଭୋକ ନଷ୍ଟ ହେବା, କେଶହାନୀ, ମୁଣ୍ଡବିନ୍ଧା, ଥକ୍କା, ଜବରଦଖଲ, ରାସ/ଦାଗ, ରକ୍ତରେ ନିମ୍ନ ଧଳା ରକ୍ତ କଣିକା ସ୍ତର ଏବଂ କମ୍ ପ୍ଲାଲେଟ୍ ସ୍ତର ହୋଇପାରେ ।^[୩] ଇଞ୍ଜେକ୍ସନ ଗ୍ରହଣ କରୁଥିବା ଲୋକଙ୍କର ସେହି ସ୍ଥାନରେ ଯନ୍ତ୍ରଣା, ଲାଲ ପଡ଼ିବା,ଗଲୁ, କିମ୍ବା ଘା/ବ୍ରୁଇ ହୋଇପାରେ ।^[୩] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମୋସାଇଷ୍ଟିସ ଜିରୋଭେଷି ନିମୋନିଆ, ଅନ୍ୟାନ୍ୟ କର୍କଟ ଏବଂ ପୁନଃ ସକ୍ରିୟ ହେପାଟାଇଟିସ ବି ହୋଇପାରେ ।^[୪] ଏହା ଏକ ଆଲକାଇଲେଟିଂ ଏଜେଣ୍ଟ ।^[୩]

୧୯୯୯ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଟେମୋଜୋଲୋମାଇଡ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ୨୫୦ ମିଗ୍ରାର ପାଞ୍ଚଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ମସିହା ସୁଦ୍ଧା ୫୩୦ ଡଲାର ଥିଲା ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୧୩୫ ଡଲାର ଅଟେ ।^[୬]

ଆଧାର

↑ "Temozolomide". Drugs.com. 4 May 2020. Archived from the original on 29 August 2021. Retrieved 7 May 2020.
↑ "Temodal Capsules - Summary of Product Characteristics (SmPC)". (emc). 24 October 2019. Archived from the original on 20 September 2020. Retrieved 7 May 2020.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Temodal EPAR". European Medicines Agency (EMA). Archived from the original on 22 October 2020. Retrieved 7 May 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ ^୪.୦ ^୪.୧ "Temozolomide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 August 2021. Retrieved 25 September 2021.
↑ ^୫.୦ ^୫.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 949. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Temozolomide Prices and Temozolomide Coupons - GoodRx". GoodRx. Retrieved 25 September 2021.

[1] "Temozolomide". Drugs.com. 4 May 2020. Archived from the original on 29 August 2021. Retrieved 7 May 2020.

[2] "Temodal Capsules - Summary of Product Characteristics (SmPC)". (emc). 24 October 2019. Archived from the original on 20 September 2020. Retrieved 7 May 2020.

[EPAR2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Temodal EPAR". European Medicines Agency (EMA). Archived from the original on 22 October 2020. Retrieved 7 May 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[AHFS2021-4] ୪.୦ ^୪.୧ "Temozolomide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 August 2021. Retrieved 25 September 2021.

[BNF80-5] ୫.୦ ^୫.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 949. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[6] "Temozolomide Prices and Temozolomide Coupons - GoodRx". GoodRx. Retrieved 25 September 2021.

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