ପ୍ରିଗାବାଲିନ

ପ୍ରିଗାବାଲିନ
Clinical data
Pronunciation	/priˈɡæbəlɪn/
Trade names	Lyrica, others
Synonyms	3-isobutyl GABA, (S)-3-isobutyl-γ-aminobutyric acid
AHFS/Drugs.com	monograph
MedlinePlus	a605045
data	EU EMA: yes; US FDA: Pregabalin;
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Dependence; liability	Physical: Moderate; Psychological: Moderate
Addiction; liability	Low
Routes of; administration	By mouth
Drug class	Gabapentinoid
ATC code	N03AX16 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: Schedule V ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	High (≥90% rapidly absorbed; administration with food has no significant effect on bioavailability)
Protein binding	<1%
Metabolites	N-methylpregabalin
Onset of action	May occur within a week (pain)
Elimination half-life	6.3–11.5 hours
Duration of action	Unknown
Excretion	Kidney
Identifiers
	IUPAC name (3S)-3-(aminomethyl)-5-methylhexanoic acid;
CAS Number	148553-50-8 ;
PubChem CID	5486971;
DrugBank	DB00230 ;
ChemSpider	4589156 ;
UNII	55JG375S6M;
KEGG	D02716 ;
ChEBI	CHEBI:64356 ;
ChEMBL	CHEMBL1059 ;
ECHA InfoCard	100.119.513
Chemical and physical data
Formula	C8H17NO2
Molar mass	159.229 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C[C@H](CC(C)C)CN;
	InChI InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1 ; Key:AYXYPKUFHZROOJ-ZETCQYMHSA-N ;
(verify)

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Pregabalin

ପ୍ରିଗାବାଲିନ (ଇଂରାଜୀ ଭାଷାରେ Pregabalin, ଏକ ବିକ୍ରୟ ନାମ ଲିରିକା/ Lyrica) ଏକ ଔଷଧ ଯାହା ଅପସ୍ମାର ବାତ, ସ୍ନାୟୁ ଯନ୍ତ୍ରଣା (neuropathic pain), ଫାଇବ୍ରୋମ୍ୟାଲ୍‌ଜିଆ, ରେସ୍ଟଲେସ ଲେଗ୍ସ ସିଣ୍ଡ୍ରୋମ ଓ ଜେନେରାଲାଇଜ୍‌ଡ ଆଙ୍ଗଜାଇଟି ଡିଜଅର୍ଡ଼ର (generalized anxiety disorder) ରୋଗମାନଙ୍କର ଚିକିତ୍ସାରେ ଦିଆଯାଏ ।^[୯]^[୧୦]^[୧୧] ଆଂଶିକ ବାତ (partial seizure) ନିମନ୍ତେ ମଧ୍ୟ ଦିଅଯାଇପାରେ ।^[୯] ଅପରେଶନ ପୂର୍ବରୁ ବ୍ୟବ‌ହାର କଲେ ଯନ୍ତ୍ରଣା କମିଯାଏ କିନ୍ତୁ ପ୍ରଶାନ୍ତି ତ‌ଥା ନିଦ୍ରା ଆସେ ଓ ଚକ୍ଷୁ ସମସ୍ୟା ଉତ୍ପନ୍ନ ହୁଏ ।^[୧୨] ପାଟିରେ ଏହି ଔଷଧ ଦିଆଯାଏ ।^[୯]

ପ୍ରିଗାବାଲିନର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡ ବିନ୍ଧା, ମୁଣ୍ଡ ଓଜନିଆ (dizziness), ନିଦ୍ରାଳୁ ଭାବ (sleepiness|, ଦ୍ୱନ୍ଦ୍ୱ, କମ ସ୍ମରଣ ଶକ୍ତି, ମୋଟର ବା ପ୍ରେରକ ଅନିୟନ୍ତ୍ରଣ, ଶୁଷ୍କ ପାଟି, ଦୃଷ୍ଟି ସମସ୍ୟା ଓ ଓଜନ ବୃଦ୍ଧି ହୋଇପାରେ ।^[୯]^[୧୩] ସାଂଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ହେଲେ ଆଞ୍ଜିଓଇଡିମା, ଔଷଧ ଅପବ୍ୟବ‌ହାର (drug misuse), ଆତ୍ମହତ୍ୟା ସଙ୍କଟ ହୋଇପାରେ ।^[୯] ଅଧିକ ମାତ୍ରାରେ ଓ ଅଧିକ ଅବଧି ନିମନ୍ତେ ଔଷଧ ବ୍ୟବ‌ହାର କଲେ ଆସକ୍ତ ହୋଇଯାଏ କିନ୍ତୁ ସଠିକ୍ ମାତ୍ରାରେ (usual doses) ଖାଇଲେ ଏହି ସଙ୍କଟ କମିଯାଏ ।^[୧] ଗର୍ଭାବସ୍ଥା ଓ ସ୍ତନ୍ୟପାନ (breastfeeding) ସମୟରେ ଏହାର ନିରାପତ୍ତା ସ୍ପଷ୍ଟ ହୋଇନାହିଁ ।^[୧୪] ପ୍ରିଗାବାଲିନ ଏଇ ପ୍ରକାର ଗାବାପେଣ୍ଟନଏଡ (gabapentinoid) ଔଷଧ ଯାହା କ୍ୟାଲସିଅମ ଚ୍ୟାନେଲ (inhibiting) ଅବରୋଧ (inhibiting) କରେ ।^[୧୫]^[୧୬]

ପ୍ରିଗାବାଲିନ ସନ ୨୦୦୪ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୯] ଏହା ଗାବାପେଣ୍ଟିନର (gabapentin) ପରବର୍ତ୍ତୀ ସଂସ୍କରଣ ।^[୧୭] ସନ ୨୦୧୮ ସୁଦ୍ଧା ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକା ବ୍ୟତୀତ ଅନେକ ଦେଶମାନଙ୍କରେ ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୧୩]^[୧୮] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହି ଔଷଧର ହୋଲସେଲ ବାବଦ ଏକ ମାସରେ ପ୍ରାୟ ୪୫୦ ଆମେରିକୀୟ ଡଲାର ଖର୍ଚ୍ଚ ହୁଏ ।^[୧୯] ଏହି ସମୟରେ ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ (United Kingdom) ଏନଏଚଏସକୁ (NHS) ପ୍ରାୟ ୬ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିବାକୁ ପଡ଼ୁଥିଲା ।^[୧୩] ସନ ୨୦୧୬ରେ ଏହାର ୯ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ହୋଇ ସର୍ବାଧିକ ପ୍ରେସକ୍ରିପସନ ତାଲିକାରେ ୮୩ତମ ସ୍ଥାନରେ ଥିଲା ।^[୨୦] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହା ଏକ ସିଡ୍ୟୁଲ ୫ (Schedule V) ଅନୁସାରେ ନିୟନ୍ତ୍ରିତ ପଦାର୍ଥ (Controlled Substances Act of 1970) ।^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ Schifano, Fabrizio (2014). "Misuse and Abuse of Pregabalin and Gabapentin: Cause for Concern?". CNS Drugs. 28 (6): 491–6. doi:10.1007/s40263-014-0164-4. PMID 24760436.
↑ "Pregabalin - Drugs.com". www.drugs.com. Retrieved 2016-11-07.
↑ "A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin". Clinical Pharmacokinetics. 49 (10): 661–669. 2010. doi:10.2165/11536200-000000000-00000. PMID 20818832. {{cite journal}}: Cite uses deprecated parameter |authors= (help)
↑ "Pregabalin (Professional Patient Advice) - Drugs.com". www.drugs.com. Retrieved 2016-11-07.
↑ "Pregabalin (Professional Patient Advice)". Drugs.com.
↑ Hantson, P; Courtois, F; Borrey, D; Haufroid, V (2014). "Pregabalin-associated myoclonic encephalopathy without evidence of drug accumulation in a patient with acute renal failure". Indian Journal of Nephrology. 24 (1): 48–50. doi:10.4103/0971-4065.125102. PMC 3927193. PMID 24574633.{{cite journal}}: CS1 maint: unflagged free DOI (link)
↑ Randinitis, Edward J.; Posvar, Edward L.; Alvey, Christine W.; Sedman, Allen J.; Cook, Jack A.; Bockbrader, Howard N. (2003). "Pharmacokinetics of Pregabalin in Subjects with Various Degrees of Renal Function". The Journal of Clinical Pharmacology. 43 (3): 277–83. doi:10.1177/0091270003251119. PMID 12638396.
↑ Lilley, Linda Lane; Collins, Shelly Rainforth; Snyder, Julie S. (2015). Pharmacology and the Nursing Process. Elsevier Health Sciences. p. 227. ISBN 9780323358286.
↑ ^୯.୦ ^୯.୧ ^୯.୨ ^୯.୩ ^୯.୪ ^୯.୫ ^୯.୬ "Pregabalin". The American Society of Health-System Pharmacists. Retrieved 3 February 2019.
↑ Frampton, James E. (2014). "Pregabalin: A Review of its Use in Adults with Generalized Anxiety Disorder". CNS Drugs. 28 (9): 835–54. doi:10.1007/s40263-014-0192-0. PMID 25149863.
↑ Iftikhar, IH; Alghothani, L; Trotti, LM (December 2017). "Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis". European Journal of Neurology. 24 (12): 1446–1456. doi:10.1111/ene.13449. PMID 28888061.
↑ Mishriky, B. M.; Waldron, N. H.; Habib, A. S. (January 2015). "Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis". British Journal of Anaesthesia. 114 (1): 10–31. doi:10.1093/bja/aeu293. ISSN 1471-6771. PMID 25209095.
↑ ^୧୩.୦ ^୧୩.୧ ^୧୩.୨ British National Formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 323. ISBN 9780857113382.
↑ "Pregabalin Use During Pregnancy". Drugs.com. Retrieved 4 February 2019.
↑ "Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use". Expert Review of Neurotherapeutics. 16 (11): 1263–1277. 2016. doi:10.1080/14737175.2016.1202764. PMID 27345098. {{cite journal}}: Cite uses deprecated parameter |authors= (help)
↑ "Acute modulation of calcium currents and synaptic transmission by gabapentinoids". Channels (Austin). 4 (6): 490–496. 2010. doi:10.4161/chan.4.6.12864. PMID 21150315. {{cite journal}}: Cite uses deprecated parameter |authors= (help)
↑ Kaye, Alan David; Vadivelu, Nalini; Urman, Richard D. (2014). Substance Abuse: Inpatient and Outpatient Management for Every Clinician. Springer. p. 324. ISBN 9781493919512.
↑ "Generic Lyrica Availability". Drugs.com. Retrieved 4 February 2019.
↑ "NADAC as of 2019-01-30". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-27. Retrieved 4 February 2019.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ବାହ୍ୟ ଲିଙ୍କ

U.S. prescribing information

[Sch2014-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ Schifano, Fabrizio (2014). "Misuse and Abuse of Pregabalin and Gabapentin: Cause for Concern?". CNS Drugs. 28 (6): 491–6. doi:10.1007/s40263-014-0164-4. PMID 24760436.

[2] "Pregabalin - Drugs.com". www.drugs.com. Retrieved 2016-11-07.

[Bock2010-3] "A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin". Clinical Pharmacokinetics. 49 (10): 661–669. 2010. doi:10.2165/11536200-000000000-00000. PMID 20818832. {{cite journal}}: Cite uses deprecated parameter |authors= (help)

[4] "Pregabalin (Professional Patient Advice) - Drugs.com". www.drugs.com. Retrieved 2016-11-07.

[Drugs.com-5] "Pregabalin (Professional Patient Advice)". Drugs.com.

[6] Hantson, P; Courtois, F; Borrey, D; Haufroid, V (2014). "Pregabalin-associated myoclonic encephalopathy without evidence of drug accumulation in a patient with acute renal failure". Indian Journal of Nephrology. 24 (1): 48–50. doi:10.4103/0971-4065.125102. PMC 3927193. PMID 24574633.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[7] Randinitis, Edward J.; Posvar, Edward L.; Alvey, Christine W.; Sedman, Allen J.; Cook, Jack A.; Bockbrader, Howard N. (2003). "Pharmacokinetics of Pregabalin in Subjects with Various Degrees of Renal Function". The Journal of Clinical Pharmacology. 43 (3): 277–83. doi:10.1177/0091270003251119. PMID 12638396.

[8] Lilley, Linda Lane; Collins, Shelly Rainforth; Snyder, Julie S. (2015). Pharmacology and the Nursing Process. Elsevier Health Sciences. p. 227. ISBN 9780323358286.

[AHFS2019-9] ୯.୦ ^୯.୧ ^୯.୨ ^୯.୩ ^୯.୪ ^୯.୫ ^୯.୬ "Pregabalin". The American Society of Health-System Pharmacists. Retrieved 3 February 2019.

[10] Frampton, James E. (2014). "Pregabalin: A Review of its Use in Adults with Generalized Anxiety Disorder". CNS Drugs. 28 (9): 835–54. doi:10.1007/s40263-014-0192-0. PMID 25149863.

[11] Iftikhar, IH; Alghothani, L; Trotti, LM (December 2017). "Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis". European Journal of Neurology. 24 (12): 1446–1456. doi:10.1111/ene.13449. PMID 28888061.

[12] Mishriky, B. M.; Waldron, N. H.; Habib, A. S. (January 2015). "Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis". British Journal of Anaesthesia. 114 (1): 10–31. doi:10.1093/bja/aeu293. ISSN 1471-6771. PMID 25209095.

[BNF76-13] ୧୩.୦ ^୧୩.୧ ^୧୩.୨ British National Formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 323. ISBN 9780857113382.

[Preg2019-14] "Pregabalin Use During Pregnancy". Drugs.com. Retrieved 4 February 2019.

[Cal2016-15] "Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use". Expert Review of Neurotherapeutics. 16 (11): 1263–1277. 2016. doi:10.1080/14737175.2016.1202764. PMID 27345098. {{cite journal}}: Cite uses deprecated parameter |authors= (help)

[Uch2010-16] "Acute modulation of calcium currents and synaptic transmission by gabapentinoids". Channels (Austin). 4 (6): 490–496. 2010. doi:10.4161/chan.4.6.12864. PMID 21150315. {{cite journal}}: Cite uses deprecated parameter |authors= (help)

[17] Kaye, Alan David; Vadivelu, Nalini; Urman, Richard D. (2014). Substance Abuse: Inpatient and Outpatient Management for Every Clinician. Springer. p. 324. ISBN 9781493919512.

[Generic_Lyrica_Availability-18] "Generic Lyrica Availability". Drugs.com. Retrieved 4 February 2019.

[19] "NADAC as of 2019-01-30". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-27. Retrieved 4 February 2019.

[20] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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