ମିନୋସାଇକ୍ଲିନ

ମିନୋସାଇକ୍ଲିନ
Clinical data
Trade names	Minocin, Minomycin, Akamin, Amzeeq, others
AHFS/Drugs.com	monograph
MedlinePlus	a682101
data	US DailyMed: Minocycline;
Pregnancy; category	AU: D ; ;
Routes of; administration	By mouth, intravenous, topical
ATC code	J01AA08 (WHO) A01AB23, D10AF07;
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	90–100%
Protein binding	70–75%
Metabolism	Liver
Elimination half-life	14–22 (11–26) hours
Excretion	Mostly fecal, 10–15% renal
Identifiers
	IUPAC name (2E,4S,4aR,5aS,12aR)-2-(Amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6- tetrahydro-4H-tetracene-1,3,12-trione;
CAS Number	10118-90-8 ;
PubChem CID	54675783;
DrugBank	DB01017 ;
ChemSpider	16735907 ;
UNII	FYY3R43WGO;
KEGG	D05045 ;
ChEBI	CHEBI:50694 ;
ChEMBL	CHEMBL1434 ;
ECHA InfoCard	100.226.626
Chemical and physical data
Formula	C23H27N3O7
Molar mass	୪୫୭.୪୮ g·mol−1
3D model (JSmol)	Interactive image;
Specific rotation	= −166°
Solubility in water	Low
	SMILES CN(C)c1ccc(c2c1C[C@H]3C[C@H]4[C@@H](C(=C(C(=O)[C@]4(C(=C3C2=O)O)O)C(=O)N)O)N(C)C)O;
	InChI InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1 ; Key:DYKFCLLONBREIL-KVUCHLLUSA-N ;
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ମିନୋସାଇକ୍ଲିନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବିକ୍ରୟ ନା ମିନୋସିନ, ହେଉଛି ଏକ ଟେଟ୍ରାସାଇକ୍ଲିନ ଆଣ୍ଟିବାୟୋଟିକ ଯାହା ନିମୋନିଆ ପରି ଅନେକ ଜୀବାଣୁ ସଂକ୍ରମଣର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୩] ^[୫] ଟେଟ୍ରାସାଇକ୍ଲିନ୍ ଡକ୍ସିସାଇକ୍ଲିନ୍ ଅପେକ୍ଷା ଏହା ସାଧାରଣତଃ କମ୍ ପସନ୍ଦ କରାଯାଏ | ^[୬] ^[୭] ଏହା ବ୍ରଣ ଏବଂ ରିଉମାଟଏଡ ଆର୍ଥ୍ରାଇଟିସର ଚିକିତ୍ସା ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୁଏ | ^[୭] ^[୮] ଏହା ପାଟିରେ ଦିଆଯାଏ କିମ୍ବା ଚର୍ମରେ ପ୍ରୟୋଗ କରାଯାଏ | ^[୬] ^[୯]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ତରଳ ଝାଡ଼ା, ମୁଣ୍ଡ ବୁଲାଇବା, ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ଏବଂ ବୃକ୍‌କ ସମସ୍ୟା ହୋଇପାରେ | ^[୩] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫିଲାକ୍‌ସିସ, ଲୁପସ୍ ପରି ସିଣ୍ଡ୍ରୋମ ଏବଂ ପ୍ରକାଶ ସୁଗ୍ରାହୀ ବା ଫୋଟୋସେନସିଟିଭ ହୋଇପାରେ | ^[୬] ଗର୍ଭାବସ୍ଥାର ପରବର୍ତ୍ତୀ ଭାଗରେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ଏବଂ ସ୍ତନ୍ୟପାନ ସମୟରେ ନିରାପତ୍ତା ଅସ୍ପଷ୍ଟ ଅଟେ | ^[୧୦] ଏହା ବ୍ୟାକ୍ଟେରିଆର ପ୍ରୋଟିନ୍ ତିଆରି କରିବାର କ୍ଷମତା ହ୍ରାସ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ଯାହାଦ୍ୱାରା ଏହାର ବୃଦ୍ଧି ବନ୍ଦ ହୋଇଯାଏ | ^[୬]

ମିନୋସାଇକ୍ଲିନ୍ ୧୯୬୧ରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୭୧ ମସିହାରେ ବ୍ୟବସାୟିକ ବ୍ୟବହାରରେ ଆସିଥିଲା | ^[୧୧] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସର ଯୋଗାଣ ୨୦୧୯ ସୁଦ୍ଧା ମୂଲ୍ୟ ୧୪ ପାଉଣ୍ଡ ଅଟେ । ^[୫] ^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୧୨ ଡଲାର ଅଟେ । ^[୧୨] ୨୦୧୭ ରେ, ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୩୭ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଦୁଇ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୧୩] ^[୧୪]

ଆଧାର

↑ "Minocycline Use During Pregnancy". Drugs.com. 4 December 2018. Retrieved 16 May 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ Dinnendahl, V; Fricke, U, eds. (2010). Arzneistoff-Profile (in ଜର୍ମାନ). Vol. 7 (24 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. Minocyclin. ISBN 978-3-7741-9846-3.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Minocycline Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 7 January 2019. Retrieved 23 March 2019.
↑ DrugBank: DB01017 (Minocycline)
↑ ^୫.୦ ^୫.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 556. ISBN 9780857113382.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "Minocycline Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 7 January 2019. Retrieved 23 March 2019.
↑ ^୭.୦ ^୭.୧ ^୭.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 556. ISBN 9780857113382.
↑ "Minocycline topical foam" (PDF). FDA. Archived from the original (PDF) on 22 February 2020. Retrieved 23 February 2020.
↑ "Minocycline topical foam" (PDF). FDA. Archived (PDF) from the original on 22 February 2020. Retrieved 23 February 2020.
↑ "Minocycline Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 3 March 2019.
↑ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 489. ISBN 9783527607495. Archived from the original on 2020-08-01. Retrieved 2020-08-05.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Minocycline Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

[Drugs.com_pregnancy-1] "Minocycline Use During Pregnancy". Drugs.com. 4 December 2018. Retrieved 16 May 2020.

[Arzneistoff-Profile-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ Dinnendahl, V; Fricke, U, eds. (2010). Arzneistoff-Profile (in ଜର୍ମାନ). Vol. 7 (24 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. Minocyclin. ISBN 978-3-7741-9846-3.

[AHFS2019-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Minocycline Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 7 January 2019. Retrieved 23 March 2019.

[4] DrugBank: DB01017 (Minocycline)

[BNF76-5] ୫.୦ ^୫.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 556. ISBN 9780857113382.

[autogen3-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "Minocycline Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 7 January 2019. Retrieved 23 March 2019.

[autogen2-7] ୭.୦ ^୭.୧ ^୭.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 556. ISBN 9780857113382.

[Amzeeq-Label-8] "Minocycline topical foam" (PDF). FDA. Archived from the original (PDF) on 22 February 2020. Retrieved 23 February 2020.

[autogen4-9] "Minocycline topical foam" (PDF). FDA. Archived (PDF) from the original on 22 February 2020. Retrieved 23 February 2020.

[Preg2019-10] "Minocycline Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 3 March 2019.

[FischerGanellin2006-11] Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 489. ISBN 9783527607495. Archived from the original on 2020-08-01. Retrieved 2020-08-05.

[NADAC2019-12] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[13] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[14] "Minocycline Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

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