ଡାଇକ୍ଲୋକ୍ସାସିଲିନ

ଡାଇକ୍ଲୋକ୍ସାସିଲିନ
Clinical data
Pronunciation	dye klox' a sil' in
AHFS/Drugs.com	monograph
MedlinePlus	a685017
Pregnancy; category	AU: B2 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	60 to 80%
Protein binding	98%
Metabolism	Liver
Elimination half-life	0.7 hours
Excretion	Kidney and biliary
Identifiers
	IUPAC name (2S,5R,6R)-6-{[3-(2,6-dichlorophenyl)-5-methyl-; oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-; 1-azabicyclo[3.2.0]heptane-2-carboxylic acid;
ECHA InfoCard	100.019.535
Chemical and physical data
Formula	C19H17Cl2N3O5S
Molar mass	୪୭୦.୩୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)[C@@H]3N4C(=O)[C@@H](NC(=O)c2c(onc2c1c(Cl)cccc1Cl)C)[C@H]4SC3(C)C;
	InChI InChI=1S/C19H17Cl2N3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1 ; Key:YFAGHNZHGGCZAX-JKIFEVAISA-N ;
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ଡାଇକ୍ଲୋକ୍ସାସିଲିନ ହେଉଛି ଏକ ଆଣ୍ଟିବାୟୋଟିକ୍ ଯାହା ଷ୍ଟାଫିଲୋକୋକାଲ ସଂକ୍ରମଣର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ସଂକ୍ରମଣ ମଧ୍ୟରେ ସେଲ୍ୟୁଲାଟିସ, ଓଷ୍ଟିଓମାୟେଲାଇଟିସ ଏବଂ ନିମୋନିଆ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୩] ପେନିସିଲିନେଜ ପ୍ରତିରୋଧକ ରୋଗରେ ଏହା ପ୍ରଭାବଶାଳୀ ଥିବାବେଳେ ଏହା ମେଥିସିଲିନ ରେଜିଷ୍ଟାଣ୍ଟ ସ୍ଟାଫିଲୋକୋକସ (MRSA) ପାଇଁ ପ୍ରଭାବଶାଳୀ ନୁହେଁ | ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ତରଳ ଝାଡ଼ା, ରାସ ଏବଂ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍‌ସିସ, କ୍ଲୋଷ୍ଟ୍ରିଡିଅମ୍ ଡିଫିସିଲ ତରଳ ଝାଡ଼ା ଏବଂ କମ୍ ଶ୍ୱେତ ରକ୍ତ କଣିକା ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଅପେକ୍ଷାକୃତ ନିରାପଦ ମନେହୁଏ, କିନ୍ତୁ ଭଲ ଭାବରେ ଏହାର ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ ।^[୪] ଏହା ଏକ β- ଲାକ୍ଟାମ ଆଣ୍ଟିବାୟୋଟିକ୍ ଏବଂ ପେନିସିଲିନ।^[୧] ଜୀବାଣୁ କୋଷ କାନ୍ଥରେ ହସ୍ତକ୍ଷେପ କରି ଏହା କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୧]

୧୯୬୧ ମସିହାରେ ଡାଇକ୍ଲୋକ୍ସାସିଲିନ ପ୍ୟାଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୬୮ରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୫୦୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୪୦ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୩୦ ଡଲାର ଥିଲା ।^[୬]

ଆଧାର[ସମ୍ପାଦନା]

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Dicloxacillin". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 28 August 2021. Retrieved 24 December 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Dicloxacillin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 24 December 2021.
↑ "289107 DICLOXACILLIN MYLAN 500 dicloxacillin (as sodium) 500 mg capsule bottle". Archived from the original on 11 January 2022. Retrieved 24 December 2021.
↑ "Dicloxacillin Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 24 December 2021.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 491. ISBN 9783527607495. Archived from the original on 2021-05-20. Retrieved 2020-12-01.
↑ "Dicloxacillin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 6 February 2017. Retrieved 24 December 2021.

[Liv2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Dicloxacillin". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 28 August 2021. Retrieved 24 December 2021.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ "Dicloxacillin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 24 December 2021.

[3] "289107 DICLOXACILLIN MYLAN 500 dicloxacillin (as sodium) 500 mg capsule bottle". Archived from the original on 11 January 2022. Retrieved 24 December 2021.

[4] "Dicloxacillin Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 24 December 2021.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 491. ISBN 9783527607495. Archived from the original on 2021-05-20. Retrieved 2020-12-01.

[6] "Dicloxacillin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 6 February 2017. Retrieved 24 December 2021.

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