ଓଲାଞ୍ଜାପିନ

ଓଲାଞ୍ଜାପିନ
Clinical data
Trade names	Zyprexa, others
AHFS/Drugs.com	monograph
MedlinePlus	a601213
data	EU EMA: yes; US FDA: Olanzapine;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ;
Routes of; administration	By mouth, intramuscular injection
ATC code	N05AH03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; NZ: Prescription medicine; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	60-65%
Protein binding	93%
Metabolism	Liver (direct glucuronidation and CYP1A2 mediated oxidation)
Elimination half-life	33 hours, 51.8 hours (elderly)
Excretion	Urine (57%; 7% as unchanged drug), faeces (30%)
Identifiers
	IUPAC name 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine;
CAS Number	132539-06-1 ;
PubChem CID	4585;
IUPHAR/BPS	47;
DrugBank	DB00334 ;
ChemSpider	10442212 ;
UNII	N7U69T4SZR;
KEGG	D00454 ;
ChEBI	CHEBI:7735 ;
ChEMBL	CHEMBL715 ;
ECHA InfoCard	100.125.320
Chemical and physical data
Formula	C17H20N4S
Molar mass	312.439
3D model (JSmol)	Interactive image;
Melting point	195 °C (383 °F)
Solubility in water	Practically insoluble in water mg/mL (20 °C)
	SMILES CN1CCN(CC1)C/2=N/c4ccccc4Nc3sc(C)cc\23;
	InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3 ; Key:KVWDHTXUZHCGIO-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Olanzapine

ଓଲାଞ୍ଜାପିନ (ଇଂରାଜୀ ଭାଷାରେ Olanzapine, ଏକ ବିକ୍ରୟ ନାମ ଜାଇପ୍ରେକ୍ସ/ Zyprexa) ଏକ ପ୍ରକାର ଅସ୍ୱାଭାବିକ ଆଣ୍ଟିସାଇକୋଟିକ ଔଷଧ ଯାହା ସିଜୋଫ୍ରେନିଆ ଓ ବାଇପୋଲାର ଡିଜଅଡର ରୋଗ ଚିକିତ୍ସାରେ ବ୍ୟବ‌ହୃତ କରାଯାଏ ।^[୬] ନୂଆ ସିଜୋଫ୍ରେନିଆ ରୋଗରେ ବା ଦୀର୍ଘକାଳୀରୁ ଥିବା ରୋଗର ସଂରକ୍ଷଣ ଚିକିତ୍ସା ନିମନ୍ତେ ଦିଆଯାଏ ।^[୬] ଏହା ପାଟିରେ ବା ମାଂସପେଶୀରେ ଇଞ୍ଜେକସନ (injection into a muscle) ଆକାରରେ ଦିଆଯାଏ ।^[୬]

ଓଲାଞ୍ଜାପିନର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଓଜନ ବୃଦ୍ଧି, ଚଳପ୍ରଚଳ ଅସୁବିଧା (movement disorders), ମୁଣ୍ଡ ଓଜନିଆ ଲାଗିବା, ଥକ୍କା ଅନୁଭବ, କୋଷ୍ଠକାଠିନ୍ୟ ଓ ଶୁଷ୍କ ପାଟି ଇତ୍ୟାଦି ଅସୁବିଧା ହୁଏ ।^[୬] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଠିଆରେ ନିମ୍ନ ରକ୍ତଚାପ (low blood pressure with standing), ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା (allergic reactions), ନିଉରୋଲେପ୍ଟିକ ମାଲିଗନାଣ୍ଟ ସିଣ୍ଡ୍ରୋମ (neuroleptic malignant syndrome), ଅଧିକ ରକ୍ତ ଶର୍କରା (high blood sugar), ବାତ (seizures), ଗାଇନେକୋମାସ୍ଟିଆ (gynecomastia) ଓ ଟାର୍ଡିଭ ଡିକାଇନେସିଆ (tardive dyskinesia) ହୋଇପାରେ ।^[୬] ପୂର୍ବରୁ ଡିମେନ୍ସିଆ ରୋଗ ଥାଇ ଏହି ଔଷଧ ଦେଲେ ମୃତ୍ୟୁ ସଙ୍କଟ ବଢ଼ିଯାଏ ।^[୬] ଗର୍ଭାବସ୍ଥାରେ ଶେଷ ଭାଗରେ ଏହି ଔଷଧ ଦେଲେ ଶିଶୁର ଜନ୍ମ ପରେ କିଛି ସମୟ ପାଇଁ ଚଳନ (movement disorder) ଅସୁବିଧା ହୁଏ ।^[୬] ଏହା କିପରି କାର୍ଯ୍ୟକରେ ତାହା ସ୍ପଷ୍ଟ ଜଣାନଥିଲେ ମଧ୍ୟ ଡୋପାମିନ୍ ଓ ସେରୋଟୋନିନ ରିସେପ୍ଟର (serotonin receptor) ଦୁଇଟିକୁ ଅବରୋଧ କରେ ।^[୬] ଏହି ଔଷଧକୁ ଅସ୍ୱାଭାବିକ ଆଣ୍ଟିସାଇକୋଟିକ (atypical antipsychotic) ଶ୍ରେଣୀରେ ରଖାଯାଏ ।^[୬]

ଓଲାଞ୍ଜାପିନ ସନ ୧୯୭୧ରେ ପେଟେଣ୍ଟ ହେବା ପରେ ସନ ୧୯୯୬ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୭]^[୬] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୦.୨୫ ଆମେରିକୀୟ ଡଲାରର କମ୍ ।^[୮] ସନ ୨୦୧୬ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ୨ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ହୋଇଥିଲା ।^[୯]

ଆଧାର

↑ Drugs.com Drugs.com international listings for Olanzapine Page accessed August 4, 2015
↑ Kassahun, Kelem; Mattiuz, Edward; Nyhart, Eldon (January 1, 1997). DISPOSITION AND BIOTRANSFORMATION OF THE ANTIPSYCHOTIC AGENT OLANZAPINE IN HUMANS. Drug Metabolism and Disposition. p. 81. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ Callaghan JT, Bergstrom RF, Ptak LR, et al. (September 1999). "Olanzapine: pharmacokinetic and pharmacodynamic profile". Clin Pharmacokinetics. 37 (3): 177–193. doi:10.2165/00003088-199937030-00001. PMID 10511917.
↑ Mauri MC, Volonteri LS, Colasanti A, et al. (2007). "Clinical pharmacokinetics of atypical antipsychotics: a critical review of the relationship between plasma concentrations and clinical response". Clinical Pharmacokinetics. 46 (5): 359–88. doi:10.2165/00003088-200746050-00001. PMID 17465637.
1 2 3 4 "PRODUCT INFORMATION OLANZAPINE SANDOZ® 2.5mg/5mg/7.5mg/10mg/15mg/20mg FILM-COATED TABLETS" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 8 June 2012. Retrieved 26 November 2013.
1 2 3 4 5 6 7 8 9 10 11 "Olanzapine, Olanzapine Pamoate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Retrieved 24 December 2018.
↑ Taylor D, Paton C, Kapur S (2015). The Maudsley Prescribing Guidelines in Psychiatry (12th ed.). London, U K: Wiley-Blackwell. p. 16. ISBN 978-1-118-75460-3.
↑ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ବାହ୍ୟ ଲିଙ୍କ

Zyprexa.com - official Zyprexa brand website from Eli Lilly and Company
Zyprexa package insert
Berenson, Alex (December 17, 2006). "Lilly Settles With 18,000 Over Zyprexa". The New York Times. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[Drugnames-1] Drugs.com Drugs.com international listings for Olanzapine Page accessed August 4, 2015

[2] Kassahun, Kelem; Mattiuz, Edward; Nyhart, Eldon (January 1, 1997). DISPOSITION AND BIOTRANSFORMATION OF THE ANTIPSYCHOTIC AGENT OLANZAPINE IN HUMANS. Drug Metabolism and Disposition. p. 81. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[3] Callaghan JT, Bergstrom RF, Ptak LR, et al. (September 1999). "Olanzapine: pharmacokinetic and pharmacodynamic profile". Clin Pharmacokinetics. 37 (3): 177–193. doi:10.2165/00003088-199937030-00001. PMID 10511917.

[4] Mauri MC, Volonteri LS, Colasanti A, et al. (2007). "Clinical pharmacokinetics of atypical antipsychotics: a critical review of the relationship between plasma concentrations and clinical response". Clinical Pharmacokinetics. 46 (5): 359–88. doi:10.2165/00003088-200746050-00001. PMID 17465637.

[TGA-5] 1 2 3 4 "PRODUCT INFORMATION OLANZAPINE SANDOZ® 2.5mg/5mg/7.5mg/10mg/15mg/20mg FILM-COATED TABLETS" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 8 June 2012. Retrieved 26 November 2013.

[AHFS2018-6] 1 2 3 4 5 6 7 8 9 10 11 "Olanzapine, Olanzapine Pamoate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Retrieved 24 December 2018.

[7] Taylor D, Paton C, Kapur S (2015). The Maudsley Prescribing Guidelines in Psychiatry (12th ed.). London, U K: Wiley-Blackwell. p. 16. ISBN 978-1-118-75460-3.

[8] "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.

[9] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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