ଆକାର୍ବୋସ

ଆକାର୍ବୋସ
Clinical data
Trade names	Glucobay, Precose, Prandase, others
Synonyms	(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5- {[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl- 5-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3- (hydroxymethyl)cyclohex-2-en-1-yl]amino} tetrahydro-2H-pyran-2-yl]oxy}-3,4-dihydroxy- 6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}- 6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4-triol
AHFS/Drugs.com	monograph
MedlinePlus	a696015
data	US DailyMed: Acarbose;
Pregnancy; category	AU: B3 ; US: B (No risk in non-human studies) ;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	Extremely low
Metabolism	Gastrointestinal tract
Elimination half-life	2 hours
Excretion	Kidney (less than 2%)
Identifiers
	IUPAC name O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-D-glucopyranose;
ECHA InfoCard	100.054.555
Chemical and physical data
Formula	C25H43NO18
Molar mass	୬୪୫.୬୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O([C@H]1[C@H](O)[C@@H](O)[C@H](O)O[C@@H]1CO)[C@H]4O[C@@H]([C@@H](O[C@H]3O[C@H](C)[C@@H](N[C@H]2/C=C(/CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]3O)[C@H](O)[C@H]4O)CO;
	InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1 ; Key:XUFXOAAUWZOOIT-SXARVLRPSA-N ;
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ଆକାର୍ବୋସ ହେଉଛି ଏକ ଔଷଧ ଯାହା ଉପ‌ଯୁକ୍ତ ଖାଦ୍ୟ ଏବଂ ବ୍ୟାୟାମ ସହିତ ଟାଇପ୍-୨ ମଧୁମେହର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୧] ଯେଉଁମାନେ ମେଟଫର୍ମିନ୍ ଗ୍ରହଣ କରିପାରିବେ ନାହିଁ କିମ୍ବା ଅନ୍ୟାନ୍ୟ ମଧୁମେହ ଔଷଧ ସ‌ହିତ ଏହା ବ୍ୟବହାର କରାଯାଇପାରେ । ^[୨] ଏହାର ଉପକାର ଅଳ୍ପ ଅଟେ । ^[୩] ପ୍ରତ୍ୟେକ ଭୋଜନ ସହିତ ଏହାକୁ ପାଟିରେ ଦିଆଯାଏ । ^[୨] ସର୍ବାଧିକ ପ୍ରଭାବ ନିମନ୍ତେ ୨ ସପ୍ତାହ ଲାଗିପାରେ । ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପେଟ ଯନ୍ତ୍ରଣା, ତରଳ ଝାଡ଼ା ଏବଂ ଅନ୍ତନଳୀ ଗ୍ୟାସ ବୃଦ୍ଧି ହୋଇଥାଏ । ^[୧] ଯେତେବେଳେ ଏକାକୀ ବ୍ୟବହାର କରାଯାଏ, ଏହା ସାଧାରଣତ କମ୍ ରକ୍ତରେ ଶର୍କରା ସୃଷ୍ଟି କରେ ନାହିଁ ।^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବର୍ଦ୍ଧିତ ଯକୃତ ଏନଜାଇମ୍ ହୋଇପାରେ । ^[୨] ଅନ୍ତନଳୀରେ ଅବରୋଧ ହେବାର ଆଶଙ୍କା ଥିବା ଲୋକଙ୍କ ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ। ^[୩] କାର୍ବୋହାଇଡ୍ରେଟ୍ ହଜମକୁ ମନ୍ଥର କରି ଏହା କାମ କରେ । ^[୨]

୧୯୯୫ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଆକାର୍ବୋଜ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୧] ଏହା ଏକ ଜେନେରିକ୍ ଔଷଧ ନାମରେ ଉପଲବ୍ଧ । ^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏକ ମାସର ଔଷଧ ଖର୍ଚ୍ଚ ୨୦୨୧ରେ ୧୬ ଡଲାର ଥିଲା । ^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ମୂଲ୍ୟ ପ୍ରାୟ ୧୫ପାଉଣ୍ଡ । ^[୩]

ଆଧାର

1 2 3 "Acarbose Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 August 2020. Retrieved 18 July 2021.
1 2 3 4 5 6 "Acarbose Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 August 2020. Retrieved 18 July 2021.
1 2 3 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 729. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Acarbose Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 23 October 2016. Retrieved 18 July 2021.
↑ "Acarbose Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 23 October 2016. Retrieved 18 July 2021.

[AHFS2021-1] 1 2 3 "Acarbose Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 August 2020. Retrieved 18 July 2021.

[autogen1-2] 1 2 3 4 5 6 "Acarbose Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 August 2020. Retrieved 18 July 2021.

[BNF80-3] 1 2 3 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 729. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[GX2021-4] "Acarbose Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 23 October 2016. Retrieved 18 July 2021.

[autogen4-5] "Acarbose Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 23 October 2016. Retrieved 18 July 2021.

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