ସେଫେପାଇମ

ସେଫେପାଇମ
Clinical data
Pronunciation	/ˈsɛfɪpiːm/ or /ˈkɛfɪpiːm/
Trade names	Maxipime, Voco, Renapime, others
Synonyms	Cephepime
AHFS/Drugs.com	monograph
MedlinePlus	a698021
Pregnancy; category	AU: B1 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	Intravenous, intramuscular
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	100% (IM)
Metabolism	Liver 15%
Elimination half-life	2 hours
Excretion	Kidney 70–99%
Identifiers
	IUPAC name (6R,7R,Z)-; 7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-; 3-((1-methylpyrrolidinium-1-yl)methyl)-8-oxo-5-thia-; 1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate;
ECHA InfoCard	100.171.025
Chemical and physical data
Formula	C19H24N6O5S2
Molar mass	୪୮୦.୫୬ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	150 °C (302 °F) (dec.)
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)C[N+]4(C)CCCC4)C([O-])=O;
	InChI InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1 ; Key:HVFLCNVBZFFHBT-ZKDACBOMSA-N ;
(verify)

ସେଫେପାଇମ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ରେନାପାଇମ, ହେଉଛି ଏକ ଆଣ୍ଟିବାୟୋଟିକ୍ ଯାହା ଉଦର ସଂକ୍ରମଣ, ଶ୍ୱାସକ୍ରିୟା ସଂକ୍ରମଣ, ଚର୍ମ ଏବଂ ଚର୍ମ ଗଠନ ସଂକ୍ରମଣ, ମୂତ୍ରନଳୀ ସଂକ୍ରମଣ, ମେନିଞ୍ଜାଇଟିସ୍, ଏଣ୍ଡୋକାର୍ଡାଇଟିସ୍ ଏବଂ ସେପସିସ୍ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୧] ^[୨] ଏହା ଉଭୟ ଗ୍ରାମ ପଜିଟିଭ ଏବଂ ଗ୍ରାମ ବିରୋଧୀ ବ୍ୟାକ୍ଟେରିଆ ବିରୁଦ୍ଧରେ କାମ କରେ । ^[୩] ଏହା ଶିରା କିମ୍ବା ମାଂସପେଶୀରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ । ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ବାନ୍ତି, ରାସ, ଏବଂ ଇଞ୍ଜେକ୍ସନ ସ୍ଥାନରେ ଯନ୍ତ୍ରଣା ହୋଇପାରେ । ^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା, କ୍ଲୋଷ୍ଟ୍ରିଡିଏଡେସ୍ ଡିଫିସିଲ ସଂକ୍ରମଣ ଏବଂ ଏନସେଫାଲୋପାଥି ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ। ^[୧] ଗର୍ଭାବସ୍ଥାରେ କ୍ଷତିର କୌଣସି ପ୍ରମାଣ ନାହିଁ କିନ୍ତୁ ଏହାର ଭଲ ରୂପେ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ । ^[୪] ଏହା ଏକ ଚତୁର୍ଥ ପିଢ଼ୀର ସେଫାଲୋସ୍ପୋରିନ୍ । ^[୫]

୧୯୮୨ ମସିହାରେ ସେଫେପାଇମ ପ୍ୟାଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୯୪ରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୬] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ୨ ଗ୍ରାମର ୧୦ଟି ଡୋଜ୍ ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୧୧୦ ପାଉଣ୍ଡ ଅଟେ। ^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୭୦ ଡଲାର ଅଟେ। ^[୮] ୨୦୧୯ରେ ବିଶ୍ Health ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଜରୁରୀ ic ଷଧ ତାଲିକାରୁ ଏହାକୁ ହଟାଇ ଦିଆଯାଇଥିଲା ।^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Cefepime Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 January 2021. Retrieved 30 December 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 561. ISBN 978-0857114105.
↑ "Cephalosporins". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 1 November 2021. Retrieved 30 December 2021.
↑ "Cefepime (Maxipime) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 30 December 2021.
↑ Beauduy, Camille E.; Winston, Lisa G. (2020). "43. Beta-lactam and other cell wall - & membrane - active antibiotics". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 833. ISBN 978-1-260-45231-0. Archived from the original on 10 October 2021. Retrieved 30 November 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 496. ISBN 9783527607495. Archived from the original on 19 June 2021. Retrieved 26 July 2021.
↑ "Cefepime Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 30 December 2021.
↑ "Cefepime Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 August 2020. Retrieved 30 December 2021.
↑ World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva: World Health Organization. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.

[AHFS2021-1] ୧.୦ ^୧.୧ ^୧.୨ "Cefepime Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 January 2021. Retrieved 30 December 2021.

[BNF81-2] ୨.୦ ^୨.୧ ^୨.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 561. ISBN 978-0857114105.

[Liv2021-3] "Cephalosporins". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 1 November 2021. Retrieved 30 December 2021.

[4] "Cefepime (Maxipime) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 30 December 2021.

[Katzung2021-5] Beauduy, Camille E.; Winston, Lisa G. (2020). "43. Beta-lactam and other cell wall - & membrane - active antibiotics". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 833. ISBN 978-1-260-45231-0. Archived from the original on 10 October 2021. Retrieved 30 November 2021.

[Fis2006-6] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 496. ISBN 9783527607495. Archived from the original on 19 June 2021. Retrieved 26 July 2021.

[7] "Cefepime Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 30 December 2021.

[8] "Cefepime Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 August 2020. Retrieved 30 December 2021.

[WHO21st-9] World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva: World Health Organization. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.

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