ଫସଫୋମାଇସିନ

ଫସଫୋମାଇସିନ
Clinical data
Trade names	Monuril, Monurol, others
Synonyms	Phosphomycin, phosphonomycin, fosfomycin tromethamine
AHFS/Drugs.com	monograph
MedlinePlus	a697008
Pregnancy; category	US: B (No risk in non-human studies) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	30–37% (by mouth, fosfomycin tromethamine); varies with food intake
Protein binding	Nil
Metabolism	Nil
Elimination half-life	5.7 hours (mean)
Excretion	Kidney and fecal, unchanged
Identifiers
	IUPAC name [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid;
ECHA InfoCard	100.041.315
Chemical and physical data
Formula	C3H7O4P
Molar mass	୧୩୮.୦୬ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	94 °C (201 °F)
	SMILES C[C@H]1[C@H](O1)P(=O)(O)O;
	InChI InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1 ; Key:YMDXZJFXQJVXBF-STHAYSLISA-N ;
(verify)

ଫସଫୋମାଇସିନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ମୋନୁରୋଲ୍, ଏକ ଆଣ୍ଟିବାୟୋଟିକ ଯାହା ମୁଖ୍ୟତଃ ମୂତ୍ରାଶୟ ସଂକ୍ରମଣର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୧] କିଡନୀ ସଂକ୍ରମଣ ପାଇଁ ଏହା ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୨] ବେଳେବେଳେ ଏହା ପ୍ରୋଷ୍ଟେଟ ସଂକ୍ରମଣ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୨] ଏହା ସାଧାରଣତଃ ପାଟିରେ ଦିଆଯାଏ | ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ଅଇ, ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ଯୋନୀପଥ ଇଷ୍ଟ ସଂକ୍ରମଣ ଅନ୍ତର୍ଭୁକ୍ତ | ^[୧] ଗୁରୁତର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍‌ସିସ ଏବଂ କ୍ଲୋଷ୍ଟ୍ରିଡିୟମ୍ ଡିଫାଇସିଲ୍ - ସମ୍ପର୍କୀୟ ତରଳ ଝାଡ଼ା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ | ^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କ୍ଷତିକାରକ ବୋଲି ଜଣାପଡିନଥିବାବେଳେ ମଧ୍ୟ ଏପରି ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୩] ସ୍ତନ୍ୟପାନ କରାଇବା ସମୟରେ ଗୋଟିଏ ମାତ୍ର ମାତ୍ରା ନିରାପଦ ଦେଖାଯାଏ | ^[୪] ଜୀବାଣୁର କୋଷ ପ୍ରାଚୀର ଉତ୍ପାଦନରେ ବାଧା ଦେଇ ଫସଫୋମାଇସିନ କାମ କରେ। ^[୨]

ଫସଫୋମାଇସିନ ୧୯୬୯ ମସିହାରେ ଆବିଷ୍କୃତ ହୋଇଥିଲା ଏବଂ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ୧୯୯୬ ମସିହାରେ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୫] ^[୧] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ତାଲିକାରେ ଏହାର ନାମ ଅଛି । ^[୬] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ଏକ କୋର୍ଷ ପାଇଁ ମୂଲ୍ୟ ୪.୮୬ ପାଉଣ୍ଡ | ^[୮] ୨୦୧୯ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରର ଏହି ରାଶି ପ୍ରାୟ ୯୫ ଆମେରିକୀୟ ଡଲାର ଅଟେ। ^[୯] ଏହା ମୂଳତଃ ଏକ ନିର୍ଦ୍ଦିଷ୍ଟ ପ୍ରକାର ସ୍ଟ୍ରେପ୍ଟୋମାଇସେସରୁ ଉତ୍ପାଦିତ ହୋଇଥିଲା, ଯଦିଓ ଏହା ବର୍ତ୍ତମାନ ରାସାୟନିକ ଭାବରେ ପ୍ରସ୍ତୁତ କରାଯାଉଛି | ^[୧୦]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Fosfomycin Tromethamine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2019. Retrieved 29 October 2019.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Fosfomycin Tromethamine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2019. Retrieved 29 October 2019.
↑ "Fosfomycin (Monurol) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2019. Retrieved 29 October 2019.
↑ "Fosfomycin (Monurol) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2019. Retrieved 29 October 2019.
↑ Finch, Roger G.; Greenwood, David; Whitley, Richard J.; Norrby, S. Ragnar (2010). Antibiotic and Chemotherapy E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 259. ISBN 9780702047657. Archived from the original on 2021-08-28. Retrieved 2020-05-25.
↑ "World Health Organization model list of essential medicines: 21st list 2019". 2019. {{cite journal}}: Cite journal requires |journal= (help)
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 560–561. ISBN 9780857113382.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 560–561. ISBN 9780857113382.
↑ "Fosfomycin". Archived from the original on 29 October 2019. Retrieved 29 October 2019.
↑ Finch, Roger G.; Greenwood, David; Whitley, Richard J.; Norrby, S. Ragnar (2010). Antibiotic and Chemotherapy E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 259. ISBN 9780702047657. Archived from the original on 2021-08-28. Retrieved 2020-05-25.

[AHFS2019-1] ୧.୦ ^୧.୧ ^୧.୨ "Fosfomycin Tromethamine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2019. Retrieved 29 October 2019.

[autogen1-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Fosfomycin Tromethamine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2019. Retrieved 29 October 2019.

[Preg2019-3] "Fosfomycin (Monurol) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2019. Retrieved 29 October 2019.

[autogen3-4] "Fosfomycin (Monurol) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2019. Retrieved 29 October 2019.

[Fin2010-5] Finch, Roger G.; Greenwood, David; Whitley, Richard J.; Norrby, S. Ragnar (2010). Antibiotic and Chemotherapy E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 259. ISBN 9780702047657. Archived from the original on 2021-08-28. Retrieved 2020-05-25.

[WHO21st-6] "World Health Organization model list of essential medicines: 21st list 2019". 2019. {{cite journal}}: Cite journal requires |journal= (help)

[BNF76-7] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 560–561. ISBN 9780857113382.

[autogen4-8] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 560–561. ISBN 9780857113382.

[9] "Fosfomycin". Archived from the original on 29 October 2019. Retrieved 29 October 2019.

[autogen5-10] Finch, Roger G.; Greenwood, David; Whitley, Richard J.; Norrby, S. Ragnar (2010). Antibiotic and Chemotherapy E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 259. ISBN 9780702047657. Archived from the original on 2021-08-28. Retrieved 2020-05-25.

[୧]

[୨]

[୩]

[୪]

[୫]

[୬]

[୭]

[୮]

[୯]

[୧୦]