ବ୍ୟୁପ୍ରୋପିଅନ

ବ୍ୟୁପ୍ରୋପିଅନ
	1 : 1 mixture (racemate)
Clinical data
Pronunciation	/bjuːˈproʊpiɒn/; BEW-PROH-PEE-on
Trade names	Wellbutrin, Zyban, others
Synonyms	Amfebutamone; 3-Chloro-N-tert-butyl-β-keto-α-methylphenethylamine;; 3-Chloro-N-tert-butylcathinone;; Bupropion hydrochloride
AHFS/Drugs.com	monograph
MedlinePlus	a695033
data	US FDA: Bupropion;
Pregnancy; category	AU: B2 ; US: C (Risk not ruled out) ; ;
Dependence; liability	None to very low
Addiction; liability	None to very low
Routes of; administration	Medical: by mouth; Recreational: by mouth, insufflation, intravenous
ATC code	N06AX12 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Protein binding	84% (bupropion), 77% (hydroxybupropion metabolite), 42% (threohydrobupropion metabolite)
Metabolism	Liver (mostly CYP2B6-mediated hydroxylation, but with some contributions from CYP1A2, CYP2A6, CYP2C9, CYP3A4, CYP2E1 and CYP2C19)
Elimination half-life	12–30 hours
Excretion	Renal (87%; 0.5% unchanged), faecal (10%)
Identifiers
	IUPAC name (RS)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one;
CAS Number	34911-55-2 [PubChem];
PubChem CID	444;
IUPHAR/BPS	7135;
DrugBank	DB01156 ;
ChemSpider	431 ;
UNII	01ZG3TPX31;
KEGG	D07591 ;
ChEBI	CHEBI:3219 ;
ChEMBL	CHEMBL894 ;
Chemical and physical data
Formula	C13H18ClNO
Molar mass	239.74 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(C(C)NC(C)(C)C)C1=CC=CC(Cl)=C1;
	InChI InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 ; Key:SNPPWIUOZRMYNY-UHFFFAOYSA-N ;
(verify)

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Bupropion

ବ୍ୟୁପ୍ରୋପିଅନ (ଇଂରାଜୀ ଭାଷାରେ Bupropion, ଏକ ବିକ୍ରୟ ନାମ ୱେଲବୁଟ୍ରିନ Wellbutrin ଓ ଜାଇବାନ/ Zyban) ଏକ ଔଷଧ (medication) ଯାହା ଅବସାଦରୋଧୀ (antidepressant) ଓ ଧୂମ୍ରପାନ ବନ୍ଦ କରିବା (smoking cessation) ଚିକିତ୍ସାରେ ପ୍ରୟୋଗ କରାଯାଏ ।^[୮] ଏହା ସ୍ୱୟଂ ଏକ ଅବସାଦରୋଧୀ ଔଷଧ ଓ ପ୍ରଥମ ଧାଡ଼ିର ଏସଏସଆରସି ଅବସାଦରୋଧୀ (SSRI antidepressant) ଔଷଧ କାମ ନ‌କଲେ ଏହାକୁ ତା ସାଥିରେ ଦିଆଯାଏ ।^[୮]^[୯] ଏହା ବଟିକା ଆକାରରେ ଦିଆଯାଏ ଓ ଅଧିକାଂଶ ଦେଶମାନଙ୍କରେ ପ୍ରେସକ୍ରିପସନରେ ମିଳେ ।^[୮]

ବ୍ୟୁପ୍ରୋପିଅନର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୁଷ୍କ ପାଟି, ନିଦ୍ରା ସମସ୍ୟା, ମୁଣ୍ଡ ବିନ୍ଧା ଓ ଉତ୍ତେଜନା ହୋଇପାରେ ।^[୮] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ସାଂଘାତିକ ହେଲେ ଅଧିକ ବାତ ବା ସିଜର ସଙ୍କଟ (risk for epileptic seizures) ଓ ଆତ୍ମହତ୍ୟା ପ୍ରବଣତା ହୋଇପାରେ ।^[୮] ବାତ ସଙ୍କଟ ଯୋଗୁ ଏହାକୁ ମାର୍କେଟରୁ ପ୍ରତ୍ୟାହୃତ କରାଯାଇଥିଲା ଓ ପରେ ଏହାର ମାତ୍ରା କମ୍ କରିବା ପରେ ପୁନର୍ବାର ଆସିଲା ।^[୧୦] ଅନ୍ୟ ଅବସାଦରୋଧୀ ଔଷଧ ଭଳି ଏହାର ଯୌନ (sexual dysfunction) ଓ ନିଦ୍ରାଳୁ ଭାବ (sleepiness) ହୁଏ ନାହିଁ କିନ୍ତୁ ଓଜନ ହ୍ରାସ (weight loss) ହୋଇପାରେ ।^[୧୦] ଗର୍ଭାବସ୍ଥା ଓ ସ୍ତନ୍ୟପାନ ସମୟରେ ଏହାର ନିରାପତ୍ତା ସ୍ପଷ୍ଟ ହୋଇନାହିଁ ।^[୮]^[୧୧]

ବ୍ୟୁପ୍ରୋପିଅନ କେତେକ ଭିନ୍ନ ଭିନ୍ନ ଜୈବିକ ଟାର୍ଗେଟକୁ (biological target) ପ୍ରଭାବିତ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୧୦]^[୧୨] ଏହା ଏକ ନରଏପିନେଫ୍ରିନ-ଡୋପାମିନ ରିଅପଟେକ ଇନହିବିଟର (norepinephrine-dopamine reuptake inhibitor|/ NDRI) ଓ ନିକୋଟିନିକ ରିସେପ୍ଟର ଆଣ୍ଟାଗୋନିସ୍ଟ (nicotinic receptor antagonist) ।^[୧୨]^[୧୩] ଏହା ଏକ ପ୍ରକାର ଅସ୍ୱାଭାବିକ ଅବସାଦରୋଧୀ (atypical antidepressant) ଔଷଧ ଓ ଅନ୍ୟମାନଙ୍କଠାରୁ ପୃଥକ୍ ।^[୧୪] ରାସାୟନ ଅନୁସାରେ ବ୍ୟୁପ୍ରୋପିଅନ ଏକ ଆମିନୋକିଟୋନ (aminoketone) ଯାହା ଫେନିଥିଲାମିନ (phenethylamine) ଭଳି ଏକ ସବସ୍ଟିଚ୍ୟୁଟେଡ କାଥିନୋନ (en:substituted cathinone) ଶ୍ରେଣୀର (class) ଔଷଧ ।^[୧]^[୧୫]

ବ୍ୟୁପ୍ରୋପିଅନ ପ୍ରଥମେ ନରିମନ ମେହଟା (Nariman Mehta) ପ୍ରସ୍ତୁତ କରିଥିଲେ ଓ ସନ ୧୯୭୪ରେ ବୁରୋଜ ୱେଲକମ (Burroughs Wellcome) ପେଟେଣ୍ଟ କରିଥିଲେ ।^[୧୬] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସନ ୧୯୮୫ରେ ପ୍ରଥମେ ଏହା ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୮] ସନ ୨୦୦୦ରେ ଏହାର ବ୍ୟୁପ୍ରୋପିଅନ ନାମ ରଖିବା ପୂର୍ବରୁ ଏହାର ନାମ ପ୍ରଥମେ ଆମ୍ଫେବୁଟାମୋନ ରଖାଯାଇଥିଲା ।^[୧୭] ସନ ୨୦୧୮ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ଡୋଜର ମୂଲ୍ୟ ୦.୫୦ ଡଲାରରୁ କମ୍ ଥିଲା ।^[୧୮] ସନ ୨୦୧୬ରେ ଏହାର ୨୨୩ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ହୋଇ ୨୮ତମ ସର୍ବାଧିକ ପ୍ରେକ୍ରିପସନର ମାନ୍ୟତା ଲାଭ କରିଥିଲା ।^[୧୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Compound Summary". Bupropion. United States National Library of Medicine – National Center for Biotechnology Information. 28 July 2018. Retrieved 29 July 2018. {{cite encyclopedia}}: |work= ignored (help)
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Zyban 150 mg prolonged release film-coated tablets – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. GlaxoSmithKline UK. 1 August 2013. Retrieved 22 October 2013.
↑ ^୩.୦ ^୩.୧ "Prexaton Bupropion hydrochloride PRODUCT INFORMATION". TGA eBusiness Services. Ascent Pharma Pty Ltd. 2 October 2012. Retrieved 22 October 2013.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ଆଧାର ଭୁଲ: ଅଚଳ <ref> ଚିହ୍ନ; BupropionLabel ନାମରେ ଥିବା ଆଧାର ଭିତରେ କିଛି ଲେଖା ନାହିଁ ।
↑ Zhu, A. Z. X.; Zhou, Q.; Cox, L. S.; Ahluwalia, J. S.; Benowitz, N. L.; Tyndale, R. F. (3 September 2014). "Gene Variants in CYP2C19 Are Associated with Altered In Vivo Bupropion Pharmacokinetics but Not Bupropion-Assisted Smoking Cessation Outcomes". Drug Metabolism and Disposition. 42 (11): 1971–1977. doi:10.1124/dmd.114.060285. PMC 4201132. PMID 25187485.
↑ Zhu, A. Z. X.; Zhou, Q.; Cox, L. S.; Ahluwalia, J. S.; Benowitz, N. L.; Tyndale, R. F. (3 September 2014). "Gene Variants in CYP2C19 Are Associated with Altered In Vivo Bupropion Pharmacokinetics but Not Bupropion-Assisted Smoking Cessation Outcomes". Drug Metabolism and Disposition. 42 (11): 1971–1977. doi:10.1124/dmd.114.060285. PMC 4201132. PMID 25187485.
↑ Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-162442-8. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)^{[page needed]}
↑ ^୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ ^୮.୬ "Bupropion Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. 5 February 2018. Retrieved 15 July 2018.
↑ Schwasinger-Schmidt, TE; Macaluso, M (8 September 2018). "Other Antidepressants". Handbook of Experimental Pharmacology. doi:10.1007/164_2018_167. PMID 30194544.
↑ ^୧୦.୦ ^୧୦.୧ ^୧୦.୨ Fava M, Rush AJ, Thase ME, et al. (2005). "15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL". Prim Care Companion J Clin Psychiatry. 7 (3): 106–13. doi:10.4088/pcc.v07n0305. PMC 1163271. PMID 16027765.
↑ "Bupropion Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 24 December 2018.
↑ ^୧୨.୦ ^୧୨.୧ Dwoskin, Linda P. (29 January 2014). Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse. Elsevier Science. pp. 177–216. ISBN 978-0-12-420177-4. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ Tasman, Allan; Kay, Jerald; Lieberman, Jeffrey A.; First, Michael B.; Maj, Mario (11 October 2011). Psychiatry. John Wiley & Sons. ISBN 978-1-119-96540-4. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ Sweetman, Sean (2011). Martindale: The Complete Drug Reference (37th ed.). p. 402. ISBN 9780853699828.
↑ Dye, Leslie R.; Murphy, Christine; Calello, Diane P.; Levine, Michael D.; Skolnik, Aaron (2017). Case Studies in Medical Toxicology: From the American College of Medical Toxicology (in ଇଂରାଜୀ). Springer. p. 85. ISBN 9783319564494.
↑ Mehta NB (25 June 1974). "United States Patent 3,819,706: Meta-chloro substituted α-butylamino-propiophenones". USPTO. Archived from the original on 7 November 2017. Retrieved 2 June 2008.
↑ World Health Organization (2000). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 83" (PDF). WHO Drug Information. 14 (2). Archived from the original (PDF) on 1 February 2010. Retrieved 22 June 2009.
↑ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ବାହ୍ୟ ଲିଙ୍କ

Bupropion at Curlie
List of international brand names for bupropion

[PubChem2018-1] ୧.୦ ^୧.୧ "Compound Summary". Bupropion. United States National Library of Medicine – National Center for Biotechnology Information. 28 July 2018. Retrieved 29 July 2018. {{cite encyclopedia}}: |work= ignored (help)

[EMCsustained-2] ୨.୦ ^୨.୧ ^୨.୨ "Zyban 150 mg prolonged release film-coated tablets – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. GlaxoSmithKline UK. 1 August 2013. Retrieved 22 October 2013.

[PREXATON-3] ୩.୦ ^୩.୧ "Prexaton Bupropion hydrochloride PRODUCT INFORMATION". TGA eBusiness Services. Ascent Pharma Pty Ltd. 2 October 2012. Retrieved 22 October 2013.

[BupropionLabel-4] ୪.୦ ^୪.୧ ^୪.୨ ଆଧାର ଭୁଲ: ଅଚଳ <ref> ଚିହ୍ନ; BupropionLabel ନାମରେ ଥିବା ଆଧାର ଭିତରେ କିଛି ଲେଖା ନାହିଁ ।

[5] Zhu, A. Z. X.; Zhou, Q.; Cox, L. S.; Ahluwalia, J. S.; Benowitz, N. L.; Tyndale, R. F. (3 September 2014). "Gene Variants in CYP2C19 Are Associated with Altered In Vivo Bupropion Pharmacokinetics but Not Bupropion-Assisted Smoking Cessation Outcomes". Drug Metabolism and Disposition. 42 (11): 1971–1977. doi:10.1124/dmd.114.060285. PMC 4201132. PMID 25187485.

[6] Zhu, A. Z. X.; Zhou, Q.; Cox, L. S.; Ahluwalia, J. S.; Benowitz, N. L.; Tyndale, R. F. (3 September 2014). "Gene Variants in CYP2C19 Are Associated with Altered In Vivo Bupropion Pharmacokinetics but Not Bupropion-Assisted Smoking Cessation Outcomes". Drug Metabolism and Disposition. 42 (11): 1971–1977. doi:10.1124/dmd.114.060285. PMC 4201132. PMID 25187485.

[Bupropion_half-life-7] Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-162442-8. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)^{[page needed]}

[AHSF2018-8] ୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ ^୮.୬ "Bupropion Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. 5 February 2018. Retrieved 15 July 2018.

[Schwasinger-Schmidt2018-9] Schwasinger-Schmidt, TE; Macaluso, M (8 September 2018). "Other Antidepressants". Handbook of Experimental Pharmacology. doi:10.1007/164_2018_167. PMID 30194544.

[Fava2005-10] ୧୦.୦ ^୧୦.୧ ^୧୦.୨ Fava M, Rush AJ, Thase ME, et al. (2005). "15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL". Prim Care Companion J Clin Psychiatry. 7 (3): 106–13. doi:10.4088/pcc.v07n0305. PMC 1163271. PMID 16027765.

[11] "Bupropion Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 24 December 2018.

[Dwoskin2014-12] ୧୨.୦ ^୧୨.୧ Dwoskin, Linda P. (29 January 2014). Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse. Elsevier Science. pp. 177–216. ISBN 978-0-12-420177-4. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[TasmanKay2011-13] Tasman, Allan; Kay, Jerald; Lieberman, Jeffrey A.; First, Michael B.; Maj, Mario (11 October 2011). Psychiatry. John Wiley & Sons. ISBN 978-1-119-96540-4. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[MD37th-14] Sweetman, Sean (2011). Martindale: The Complete Drug Reference (37th ed.). p. 402. ISBN 9780853699828.

[Dye2017-15] Dye, Leslie R.; Murphy, Christine; Calello, Diane P.; Levine, Michael D.; Skolnik, Aaron (2017). Case Studies in Medical Toxicology: From the American College of Medical Toxicology (in ଇଂରାଜୀ). Springer. p. 85. ISBN 9783319564494.

[USPatent-16] Mehta NB (25 June 1974). "United States Patent 3,819,706: Meta-chloro substituted α-butylamino-propiophenones". USPTO. Archived from the original on 7 November 2017. Retrieved 2 June 2008.

[17] World Health Organization (2000). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 83" (PDF). WHO Drug Information. 14 (2). Archived from the original (PDF) on 1 February 2010. Retrieved 22 June 2009.

[18] "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.

[19] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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