ରୋପିନିରୋଲ

ରୋପିନିରୋଲ
Clinical data
Trade names	Requip, Repreve, Ronirol, others
AHFS/Drugs.com	monograph
MedlinePlus	a698013
Pregnancy; category	C;
Routes of; administration	By mouth
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Bioavailability	50%
Metabolism	Liver (CYP1A2)
Elimination half-life	5-6 hours
Identifiers
	IUPAC name 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one;
ECHA InfoCard	100.110.353
Chemical and physical data
Formula	C16H24N2O
Molar mass	୨୬୦.୩୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2Nc1cccc(c1C2)CCN(CCC)CCC;
	InChI InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19) ; Key:UHSKFQJFRQCDBE-UHFFFAOYSA-N ;
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ରୋପିନିରୋଲ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବ୍ୟବସାୟୀକ ନାମ ରିକ୍ୱିପ, ଏକ ଔଷଧ ଯାହା ପାର୍କିନ୍ସନ୍ ରୋଗ (ପିଡି) ଏବଂ ଅସ୍ଥିର ଗୋଡ ସିଣ୍ଡ୍ରୋମ (ଆରଏଲଏସ୍/restless legs syndrome)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୨] ପିଡି ରୋଗରେ ଏହାର ମାତ୍ରା ପ୍ରଭାବ ସହିତ ନିୟନ୍ତ୍ରଣ କରିବା ଆବଶ୍ୟକ ଏବଂ ଚିକିତ୍ସା ହଠାତ୍ ବନ୍ଦ ହେବା ଉଚିତ୍ ନୁହେଁ | ^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ, ବାନ୍ତି ଏବଂ ମୁଣ୍ଡ ବୁଲାଇବା ଅନ୍ତର୍ଭୁକ୍ତ | ^[୪] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଜୁଆ ମାନସିକତା (pathological gambling) ଛିଡା ହେବାବେଳେ ନିମ୍ନ ରକ୍ତଚାପ ଏବଂ ହାଲୁସିନେସନ ହୋଇପାରେ | ^[୫] ^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଏବଂ ସ୍ତନ୍ୟପାନ କରାଇବାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ | ^[୬] ଏହା ଏକ ଡୋପାମିନ ଆଗୋନିଷ୍ଟ ଏବଂ ଡୋପାମିନ ଡି୨ ରିସେପ୍ଟରକୁ ଗ୍ରିଗର ବା ଉତପ୍ରେରକ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ | ^[୫]

ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଏହା ୧୯୯୭ ମସିହାରେ ଅନୁମୋଦିତ ହୋଇଥିଲା | ^[୪] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସର ଯୋଗାଣ ୨୦୧୯ ସୁଦ୍ଧା ପ୍ରତି ମାସରେ ୩୪ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୋଇଥାଏ । ^[୨] ^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୭.୯୦ ଆମେରିକୀୟ ଡଲାର ଅଟେ। ^[୭] ୨୯୧୭ରେ, ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୦୮ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଛଅ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୮] ^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ Tompson, Debra J.; et al. (2007). "Steady-State Pharmacokinetic Properties of a 24-Hour Prolonged-Release Formulation of Ropinirole: Results of Two Randomized Studies in Patients with Parkinson's Disease". Clinical Pharmacokinetics. 29 (12): 2654–66. doi:10.1016/j.clinthera.2007.12.010. PMID 18201581.
↑ ^୨.୦ ^୨.୧ ^୨.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 419–420. ISBN 9780857113382.
↑ ^୩.୦ ^୩.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 419–420. ISBN 9780857113382.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Ropinirole Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ ^୫.୦ ^୫.୧ "Ropinirole Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ "Ropinirole Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Ropinirole Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

[TompsonD-1] ୧.୦ ^୧.୧ ^୧.୨ Tompson, Debra J.; et al. (2007). "Steady-State Pharmacokinetic Properties of a 24-Hour Prolonged-Release Formulation of Ropinirole: Results of Two Randomized Studies in Patients with Parkinson's Disease". Clinical Pharmacokinetics. 29 (12): 2654–66. doi:10.1016/j.clinthera.2007.12.010. PMID 18201581.

[BNF76-2] ୨.୦ ^୨.୧ ^୨.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 419–420. ISBN 9780857113382.

[autogen1-3] ୩.୦ ^୩.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 419–420. ISBN 9780857113382.

[AHFS2019-4] ୪.୦ ^୪.୧ ^୪.୨ "Ropinirole Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[autogen2-5] ୫.୦ ^୫.୧ "Ropinirole Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Preg2019-6] "Ropinirole Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.

[NADAC2019-7] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-8] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ref1-9] "Ropinirole Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

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