ବ୍ରିଭାରାସେଟମ

ବ୍ରିଭାରାସେଟମ
Clinical data
Pronunciation	/ˌbrɪvəˈræsətəm/ BRIV-ə-RASS-ə-təm
Trade names	Briviact, Nubriveo, Brivazen, others
AHFS/Drugs.com	monograph
MedlinePlus	a616027
data	EU EMA: yes; US DailyMed: Brivaracetam;
Pregnancy; category	AU: B3 ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth, intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; US: Schedule V ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	Nearly 100%
Protein binding	≤20%
Metabolism	Hydrolysis by amidase, CYP2C19-mediated hydroxylation
Metabolites	3 inactive metabolites
Elimination half-life	≈9 hours
Excretion	Kidneys (>95%)
Identifiers
	IUPAC name (2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl] butanamide;
ECHA InfoCard	100.118.642
Chemical and physical data
Formula	C11H20N2O2
Molar mass	୨୧୨.୨୯ g·mol−1
3D model (JSmol)	Interactive image;
Specific rotation	[α]D −60°
Melting point	72 to 77 °C (162 to 171 °F)
	SMILES O=C(N)[C@@H](N1C(=O)C[C@@H](CCC)C1)CC;
	InChI InChI=1S/C11H20N2O2/c1-3-5-8-6-10(14)13(7-8)9(4-2)11(12)15/h8-9H,3-7H2,1-2H3,(H2,12,15)/t8-,9+/m1/s1 ; Key:MSYKRHVOOPPJKU-BDAKNGLRSA-N ;

ବ୍ରିଭାରାସେଟମ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ବ୍ରାଇଭାକ୍ଟ, ହେଉଛି ଔଷଧ ଯାହା ଅପସ୍ମାରର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ, ବିଶେଷ ଭାବରେ ଆଂଶିକ-ଆରମ୍ଭ ବାତରେ । ^[୨] ଏହା ୩ବର୍ଷରୁ ଅଧିକ ଲୋକଙ୍କଠାରେ ଅନ୍ୟାନ୍ୟ ଅପସ୍ମାର ଔଷଧ ସ‌ହିତ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଏହା ପାଟିରେ କିମ୍ବା ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଇପାରେ । ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରା, ମୁଣ୍ଡ ବୁଲାଇବା, ଥକାପଣ ଏବଂ ବାନ୍ତି ଲାଗେ ହୋଇପାରେ । ^[୫] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆତ୍ମହତ୍ୟା, ସାଇକୋସିସ୍, ଆଞ୍ଜିଓଇଡିମା ଏବଂ ଉଦ୍‌ବେଗ ହୋଇପାରେ । ^[୬] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୬] ଏହା କିପରି କାର୍ଯ୍ୟ କରେ ତାହା ଅସ୍ପଷ୍ଟ; ତଥାପି ସିନାପ୍ଟିକ ଭେସିକ୍ଲପ୍ରୋଟିନ ୨ଏ ସହିତ ଜଡିତ ହୋଇପାରେ । ^[୪] ଏହା ରାସାୟନିକ ଭାବରେ ଲେଭେଟିରାସେଟମ୍ ସହିତ ସମାନ | ^[୭]

୨୦୧୬ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଏବଂ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ବ୍ରିଭାରାସେଟମ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ଔଷଧ ଖର୍ଚ୍ଚ ୨୦୨୧ ମସିହାରେ ୧୩୦ ପାଉଣ୍ଡ ଥିଲା । ^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୧,୨୦୦ ଡଲାର ଥିଲା । ^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Briviact- brivaracetam tablet, film coated Briviact- brivaracetam solution Briviact- brivaracetam injection, suspension". DailyMed. 15 May 2018. Archived from the original on 21 March 2021. Retrieved 2019-01-25.
↑ ^୨.୦ ^୨.୧ "Briviact (in Italy: Nubriveo)". Archived from the original on 29 December 2021. Retrieved 11 January 2022.
↑ "Briviact (in Italy: Nubriveo)". Archived from the original on 29 December 2021. Retrieved 11 January 2022.
↑ ^୪.୦ ^୪.୧ "Brivaracetam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 July 2021. Retrieved 11 January 2022.
↑ ^୫.୦ ^୫.୧ "DailyMed - BRIVIACT- brivaracetam tablet, film coated BRIVIACT- brivaracetam solution BRIVIACT- brivaracetam injection, suspension". dailymed.nlm.nih.gov. Archived from the original on 21 March 2021. Retrieved 11 January 2022.
↑ ^୬.୦ ^୬.୧ "DailyMed - BRIVIACT- brivaracetam tablet, film coated BRIVIACT- brivaracetam solution BRIVIACT- brivaracetam injection, suspension". dailymed.nlm.nih.gov. Archived from the original on 21 March 2021. Retrieved 11 January 2022.
↑ "Brivaracetam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 July 2021. Retrieved 11 January 2022.
↑ "Briviact Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.
↑ "Briviact Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.

[autogen1-1] ୧.୦ ^୧.୧ "Briviact- brivaracetam tablet, film coated Briviact- brivaracetam solution Briviact- brivaracetam injection, suspension". DailyMed. 15 May 2018. Archived from the original on 21 March 2021. Retrieved 2019-01-25.

[autogen2-2] ୨.୦ ^୨.୧ "Briviact (in Italy: Nubriveo)". Archived from the original on 29 December 2021. Retrieved 11 January 2022.

[EPAR2022-3] "Briviact (in Italy: Nubriveo)". Archived from the original on 29 December 2021. Retrieved 11 January 2022.

[autogen3-4] ୪.୦ ^୪.୧ "Brivaracetam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 July 2021. Retrieved 11 January 2022.

[autogen4-5] ୫.୦ ^୫.୧ "DailyMed - BRIVIACT- brivaracetam tablet, film coated BRIVIACT- brivaracetam solution BRIVIACT- brivaracetam injection, suspension". dailymed.nlm.nih.gov. Archived from the original on 21 March 2021. Retrieved 11 January 2022.

[autogen5-6] ୬.୦ ^୬.୧ "DailyMed - BRIVIACT- brivaracetam tablet, film coated BRIVIACT- brivaracetam solution BRIVIACT- brivaracetam injection, suspension". dailymed.nlm.nih.gov. Archived from the original on 21 March 2021. Retrieved 11 January 2022.

[AHFS2022-7] "Brivaracetam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 July 2021. Retrieved 11 January 2022.

[8] "Briviact Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.

[9] "Briviact Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.

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