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ଫ୍ଲୁଟାମାଇଡ

ଉଇକିପିଡ଼ିଆ‌ରୁ
ଫ୍ଲୁଟାମାଇଡ
Clinical data
Trade namesEulexin, others
SynonymsNiftolide; SCH-13521; 4'-Nitro-3'-trifluoromethyl-isobutyranilide
AHFS/Drugs.commonograph
MedlinePlusa697045
Pregnancy
category
  • D
Routes of
administration
By mouth
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityComplete (>90%)[୩]
Protein bindingFlutamide: 94–96%[୩]
Hydroxyflutamide: 92–94%[୩]
MetabolismLiver (CYP1A2)[୧][୨]
MetabolitesHydroxyflutamide[୪][୨]
Elimination half-lifeFlutamide: 5–6 hours[୫][୨]
Hydroxyflutamide: 8–10 hours[୬][୭][୨][୩]
ExcretionUrine (mainly)[୩]
Feces (4.2%)[୩]
Identifiers
  • 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
ECHA InfoCard100.033.024 Edit this at Wikidata
Chemical and physical data
FormulaC11H11F3N2O3
Molar mass୨୭୬.୨୨ g·mol−1
3D model (JSmol)
Melting point111.5 to 112.5 °C (232.7 to 234.5 °F)
  • CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F
  • InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17) checkY
  • Key:MKXKFYHWDHIYRV-UHFFFAOYSA-N checkY
  (verify)

ଫ୍ଲୁଟାମାଇଡ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଇଉଲେକ୍ସିନ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମୁଖ୍ୟତଃ ପ୍ରୋଷ୍ଟେଟ୍ କ୍ୟାନସରର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।[୮] ପ୍ରୋଷ୍ଟେଟ କର୍କଟ ପାଇଁ ଏହା ଲ୍ୟୁଟିନାଇଜିଂ ହରମୋନ-ରିଲିଜ୍ ହରମୋନ୍ (LHRH) ସହିତ ମିଳିତ ଭାବରେ ବ୍ୟବହୃତ ହୁଏ ।[୯] ଏହା ଅବାଞ୍ଛିତ କେଶ ବୃଦ୍ଧି ଏବଂ ପଲିସିଷ୍ଟିକ୍ ଓଭାରିଆନ ସିଣ୍ଡ୍ରୋମରେ କେଶ ଝଡ଼ିବା ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୁଏ ।[୧୦] ଏହାକୁ ଦିନକୁ ତିନିଥର ପାଟିରେ ଦିଆଯାଏ ।[୧୧]

ପୁରୁଷମାନଙ୍କ ମଧ୍ୟରେ ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଗରମ ଲାଲିମା, ଯୌନ‌କ୍ରିୟାରେ ଅସୁବିଧା, ସ୍ତନ ବୃଦ୍ଧି ଏବଂ ଅଇ ଲାଗେ ।[୯] ମହିଳାମାନଙ୍କ କ୍ଷେତ୍ରରେ କେବଳ ଶୁଷ୍କ ଚର୍ମ ହେବା ସ‌ହିତ ଏହାକୁ ଭଲ ଭାବରେ ସହ୍ୟ କରିହୁଏ ।[୧୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା, ଲଙ୍ଗ କ୍ୟୁଟି ସିଣ୍ଡ୍ରୋମ, ଏବଂ ଆତପଦାହ ହୋଇପାରେ ।[୯] [୮] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।[୯] ଏହା ଏକ ନନ ଷ୍ଟେରଏଡାଲ ଆଣ୍ଟିଆଣ୍ଡ୍ରୋଜେନ (NSA) ଯାହା ଆଣ୍ଡ୍ରୋଜେନ୍ ରିସେପ୍ଟର (ଆର୍) ଚୟନ କରିବା ସ‌ହିତ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।[୯]

୧୯୬୭ ମସିହାରେ ଫ୍ଲୁଟାମାଇଡ ବିଷୟ ପ୍ରଥମେ ବର୍ଣ୍ଣନା କରାଯାଇଥିଲା ଏବଂ ୧୯୮୩ରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।[୧୩] ଏହା ୧୯୮୯ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଅନୁମୋଦିତ ହୋଇଥିଲା ।[୯] ଏହା ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ସ୍ଥାନ ପାଇଛି ।[୧୪] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।[୮] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୪ ସପ୍ତାହର ଔଷଧ ବ୍ୟବ‌ହାରରର ମୂଲ୍ୟ ୧୧୦ ପାଉଣ୍ଡ ଥିଲା ।[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୮୫ ଡଲାର ଥିଲା ।[୧୫] ଏହାର ବ୍ୟବହାରକୁ ବାଇକାଲୁଟାମାଇଡ ଭଳି ଏନଏସଏଏଦ୍ୱାରା ବାରମ୍ବାର ବଦଳା ଯାଇଛି ଯେହେତୁ ଏହା ଭଲ କାମ କରେ, ଏହାର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା କମ ଏବଂ ଗ୍ରହଣ କରିବା ସହଜ ଅଟେ ।[୫] [୧୬]

ଆଧାର[ସମ୍ପାଦନା]

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