ଫୋଷ୍ଟେମସାଭିର

ଫୋଷ୍ଟେମସାଭିର
Clinical data
Trade names	Rukobia
Synonyms	Fostemsavir tromethamine, BMS-663068, GSK3684934
AHFS/Drugs.com	monograph
MedlinePlus	a620046
data	EU EMA: yes; US DailyMed: Fostemsavir;
Pregnancy; category	AU: B3 ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Identifiers
	IUPAC name {3-[(4-Benzoyl-1-piperazinyl)(oxo)acetyl]-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate;
Chemical and physical data
Formula	C25H26N7O8P
Molar mass	୫୮୩.୫0 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccccc1)N5CCN(C(=O)C(=O)c4c2c(c(ncc2OC)n3nc(nc3)C)n(c4)COP(=O)(O)O)CC5;
	InChI InChI=1S/C25H26N7O8P/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38); Key:SWMDAPWAQQTBOG-UHFFFAOYSA-N;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Fostemsavir

ଫୋଷ୍ଟେମସାଭିର (ଇଂରାଜୀ ଭାଷାରେ Fostemsavir), ରୁକୋବିୟା ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଏଚଆଇଭି/ଏଡସ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଏହା ଅନ୍ୟାନ୍ୟ ଔଷଧ ସହିତ ଏକତ୍ର ବ୍ୟବହୃତ ହୁଏ ଯେତେବେଳେ କିଛି ଚିକିତ୍ସା ଫଳପ୍ରଦ ହୁଏ ନାହିଁ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ତରଳ ଝାଡ଼ା, ରାସ ଏବଂ ପେଟ ଯନ୍ତ୍ରଣା ହୋଇପାରେ ।^[୩] ^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା, କ୍ୟୁଟି (QT) ବିସ୍ତାର, ଏବଂ ପ୍ରତିରକ୍ଷା ପୁନର୍ନିର୍ମାଣ ସିଣ୍ଡ୍ରୋମ (immune reconstitution syndrome) ହୋଇପାରେ ।^[୩] ଏହାକୁ ଶକ୍ତିଶାଳୀ ସିୱାଇପି୩ଏ (CYP3A) ପ୍ରବର୍ତ୍ତକ ସହିତ ଦିଆଯିବା ଉଚିତ ନୁହେଁ ।^[୨] ଏହା ଏଚ୍.ଆଇ.ଭି ଭୁତାଣୁ ସ‌ହିତ ଅନୁବନ୍ଧିତ ହୋଇ ତାକୁଟି କୋଷରେ ପ୍ରବେଶ ନ କରେଇବାଦ୍ୱାରା କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୨]

ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୦ ଏବଂ ୟୁରୋପରେ ୨୦୨୧ରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଫୋଷ୍ଟେମସାଭିର ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସର ଚିକିତ୍ସା ବାବଦ ୨୦୨୧ ସୁଦ୍ଧା ୨୯୦୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୮୦୦୦ ଡଲାର ଅଟେ ।^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Rukobia". Therapeutic Goods Administration (TGA). 23 July 2021. Archived from the original on 5 September 2021. Retrieved 5 September 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Rukobia EPAR". European Medicines Agency (EMA). 9 December 2020. Archived from the original on 12 February 2021. Retrieved 12 February 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Rukobia- fostemsavir tromethamine tablet, film coated, extended release". DailyMed. 2 July 2020. Archived from the original on 15 July 2020. Retrieved 14 July 2020.
↑ "Fostemsavir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 12 December 2021.
↑ "Rukobia · HIV infection". Archived from the original on 22 October 2021. Retrieved 13 December 2021.
↑ "Rukobia Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 13 December 2021.

[Rukobia_APM_summary-1] ୧.୦ ^୧.୧ "Rukobia". Therapeutic Goods Administration (TGA). 23 July 2021. Archived from the original on 5 September 2021. Retrieved 5 September 2021.

[EPAR2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Rukobia EPAR". European Medicines Agency (EMA). 9 December 2020. Archived from the original on 12 February 2021. Retrieved 12 February 2021.

[PI2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Rukobia- fostemsavir tromethamine tablet, film coated, extended release". DailyMed. 2 July 2020. Archived from the original on 15 July 2020. Retrieved 14 July 2020.

[AHFS2021-4] "Fostemsavir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 12 December 2021.

[5] "Rukobia · HIV infection". Archived from the original on 22 October 2021. Retrieved 13 December 2021.

[6] "Rukobia Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 13 December 2021.

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