ଫୋଣ୍ଡାପାରିନକ୍ସ

ଫୋଣ୍ଡାପାରିନକ୍ସ
Clinical data
Trade names	Arixtra
Synonyms	Fondaparinux sodium
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Fondaparinux;
Routes of; administration	Subcutaneous
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	N/A
Protein binding	94%
Metabolism	renally excreted unchanged
Elimination half-life	17-21 hours
Chemical and physical data
Formula	C31H43N3Na10O49S8
Molar mass	୧,୭୨୮.୦୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)N[C@@H]5[C@@H](O)[C@H](O)[C@@H](COS([O-])(=O)=O)O[C@@H]5O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@@H]1C([O-])=O)O[C@@H]4[C@@H](COS([O-])(=O)=O)O[C@H](O[C@H]3[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]2[C@H](O)[C@@H](NS([O-])(=O)=O)[C@@H](OC)O[C@@H]2COS([O-])(=O)=O)O[C@H]3C([O-])=O)[C@H](NS([O-])(=O)=O)[C@H]4OS([O-])(=O)=O;
	InChI InChI=1S/C31H53N3O49S8.10Na/c1-69-27-9(33-85(48,49)50)13(37)17(6(74-27)3-71-88(57,58)59)76-31-22(83-91(66,67)68)16(40)21(24(81-31)26(43)44)79-29-10(34-86(51,52)53)19(82-90(63,64)65)18(7(75-29)4-72-89(60,61)62)77-30-15(39)14(38)20(23(80-30)25(41)42)78-28-8(32-84(45,46)47)12(36)11(35)5(73-28)2-70-87(54,55)56;;;;;;;;;;/h5-24,27-40H,2-4H2,1H3,(H,41,42)(H,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68);;;;;;;;;;/q;10*+1/p-10/t5-,6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-,19-,20+,21+,22-,23+,24-,27+,28-,29-,30-,31-;;;;;;;;;;/m1........../s1 ; Key:XEKSTYNIJLDDAZ-JASSWCPGSA-D ;
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ଫୋଣ୍ଡାପାରିନକ୍ସ, ବିକ୍ରି ନାମ ଆରିକ୍ସଟ୍ରା, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଗଭୀର ଶିରା, ଫୁସଫୁସ, ଏବଂ ପୃଷ୍ଠ ଶିରା ଥ୍ରୋମ୍ବୋସିସରେ ରକ୍ତ ଜମାଟ, ଅସ୍ଥିର ଆଞ୍ଜିନା ଏବଂ ହୃଦ୍‌ଘାତର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ^[୩] ଏହା ଚର୍ମ ତଳେ ଇଞ୍ଜେକସନଦ୍ୱାରା ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତସ୍ରାବ ହୋଇପାରେ ।^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପ୍ଲାଲେଟ କମିଯାଇପାରେ | ^[୨] ଗୁରୁତର ବୃକ୍‌କ ସମସ୍ୟା ଥିବା ଲୋକଙ୍କପାଇଁ ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ସହିତ ଶିଶୁର କୌଣସି କ୍ଷତି ହେବାର ପ୍ରମାଣ ନାହିଁ | ^[୨] ଫ୍ୟାକ୍ଟର୍ ଏକ୍ସ ଏ (Xa)କୁ ଅବରୋଧ କରି ଏହା କାମ କରେ ।^[୩]

୨୦୦୧ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୦୨ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଫୋଣ୍ଡାପାରିନକ୍ସ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୨.୫ ମିଗ୍ରା ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୬ ପାଉଣ୍ଡ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୁଲ୍ୟ ପ୍ରାୟ ୨୦ ଡଲାର ଅଟେ।^[୫]

ଆଧା[ସମ୍ପାଦନା]

↑ Walenga JM, Jeske WP, Fareed J (2005). "Biochemical and Pharmacologic Rationale for Synthetic Heparin Polysaccharides". Chemistry and Biology of Heparin and Heparan Sulfate. Elsevier. pp. 143–177. doi:10.1016/b978-008044859-6/50006-x. ISBN 978-0-08-044859-6. The elimination half-life of AT-bound fondaparinux is 17–21 h (171,172). The subcutaneous bioavailability of fondaparinux is nearly 100% and it is distributed mainly in the blood (165,173).
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Fondaparinux Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 13 December 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Arixtra". Archived from the original on 21 June 2021. Retrieved 13 December 2021.
↑ ^୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 139. ISBN 978-0857114105.
↑ "Fondaparinux Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 April 2021. Retrieved 13 December 2021.

[Walenga_Jeske_Fareed_2005_pp._143–177-1] Walenga JM, Jeske WP, Fareed J (2005). "Biochemical and Pharmacologic Rationale for Synthetic Heparin Polysaccharides". Chemistry and Biology of Heparin and Heparan Sulfate. Elsevier. pp. 143–177. doi:10.1016/b978-008044859-6/50006-x. ISBN 978-0-08-044859-6. The elimination half-life of AT-bound fondaparinux is 17–21 h (171,172). The subcutaneous bioavailability of fondaparinux is nearly 100% and it is distributed mainly in the blood (165,173).

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Fondaparinux Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 13 December 2021.

[EPAR2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Arixtra". Archived from the original on 21 June 2021. Retrieved 13 December 2021.

[BNF81-4] ୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 139. ISBN 978-0857114105.

[5] "Fondaparinux Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 April 2021. Retrieved 13 December 2021.

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