ନିରାପାରିବ

ନିରାପାରିବ
Clinical data
Pronunciation	/nɪˈræpərɪb/; NIH-RAP-UH-rib
Trade names	Zejula
Synonyms	Niraparib tosylate, MK-4827
AHFS/Drugs.com	monograph
MedlinePlus	a617007
data	EU EMA: yes; US DailyMed: Niraparib;
Pregnancy; category	AU: D ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	73%
Protein binding	83%
Metabolism	Carboxylesterases
Metabolites	M1 (carboxylic acid)
Elimination half-life	36 hours
Excretion	48% urine, 29% feces
Identifiers
	IUPAC name 2-[4-[(3S)-3-Piperidyl]phenyl]indazole-7-carboxamide;
ECHA InfoCard	100.210.548
Chemical and physical data
Formula	C19H20N4O
Molar mass	୩୨୦.୪0 g·mol−1
3D model (JSmol)	Interactive image;
Solubility in water	0.7–1.1 mg/mL (20 °C)
	SMILES c1cc2cn(nc2c(c1)C(=O)N)c3ccc(cc3)[C@@H]4CCCNC4;
	InChI InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1 ; Key:PCHKPVIQAHNQLW-CQSZACIVSA-N ;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Niraparib

ନିରାପାରିବ, ଜେଜୁଲା ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ସରଫେସ ଏପିଥେଲିଆଲ୍-ଷ୍ଟ୍ରୋମାଲ ଟ୍ୟୁମର, ଫାଲୋପିଆନ୍ ଟ୍ୟୁବ୍ କିମ୍ବା ପ୍ରାଥମିକ ପେରିଟୋନିଆଲ୍ କର୍କଟ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ^[୩] ଏହା ସାଧାରଣତଃ ପ୍ଲାଟିନମ-ଆଧାରିତ କେମୋଥେରାପି ପରେ ବ୍ୟବହୃତ ହୁଏ। ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, କମ୍ ପ୍ଲାଟେଲେଟ୍, ଥକ୍କା, ସ୍ୱଳ୍ପ ଲାଲ ରକ୍ତ କଣିକା, କୋଷ୍ଠକାଠିନ୍ୟ, ପେଟ ଯନ୍ତ୍ରଣା, ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା, ଶୋଇବାରେ ଅସୁବିଧା, ମୁଣ୍ଡବିନ୍ଧା, ତରଳ ଝାଡ଼ା, ଅଣନିଶ୍ୱାସ, ଉଚ୍ଚ ରକ୍ତଚାପ, ଗଣ୍ଠି ଯନ୍ତ୍ରଣା ଏବଂ ଲାଲ ମୁଖମଣ୍ଡଳ ବା ଗରମ ଫ୍ଲସ୍ ହୋଇପାରେ ।^[୩] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମାୟେଲୋଡିସପ୍ଲାଷ୍ଟିକ ସିଣ୍ଡ୍ରୋମ ଏବଂ ଅନୁର୍ବରତା ହୋଇପାରେ ।^[୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୨] ଏହା ଏକ ପଲି ଏଡିପି-ରାଇବୋଜ୍ ପଲିମେରେଜ (PARP) ପ୍ରତିବନ୍ଧକ ।^[୨]

୨୦୧୭ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର କରିବା ପାଇଁ ନିରପାରିବ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ପ୍ରତିଦିନ ୨୦୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୪ ସପ୍ତାହ ଚିକିତ୍ସାର ମୂଲ୍ୟ ପ୍ରାୟ ୪,୫୦୦ ଡଲାର । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୧୬,୩୦୦ ଡଲାର ଅଟେ ।^[୬]

ଆଧାର

↑ "Zejula 100 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 19 January 2021. Retrieved 17 January 2021.
1 2 3 4 "Zejula- niraparib capsule". DailyMed. Archived from the original on 24 March 2021. Retrieved 17 January 2021.
1 2 3 4 5 "Zejula EPAR". European Medicines Agency (EMA). Archived from the original on 13 November 2020. Retrieved 17 January 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
1 2 3 "Niraparib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 13 November 2021.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1050. ISBN 978-0857114105.
↑ "Zejula Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 13 November 2021.

[Zejula_SmPC-1] "Zejula 100 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 19 January 2021. Retrieved 17 January 2021.

[PI2021-2] 1 2 3 4 "Zejula- niraparib capsule". DailyMed. Archived from the original on 24 March 2021. Retrieved 17 January 2021.

[EPAR2021-3] 1 2 3 4 5 "Zejula EPAR". European Medicines Agency (EMA). Archived from the original on 13 November 2020. Retrieved 17 January 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[AHFS2021-4] 1 2 3 "Niraparib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 13 November 2021.

[BNF81-5] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1050. ISBN 978-0857114105.

[6] "Zejula Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 13 November 2021.

[୧]

[୨]

[୩]

[୪]

[୫]

[୬]