ଡେସିଟାବାଇନ/ସେଡାଜୁରିଡାଇନ

ଡେସିଟାବାଇନ/ସେଡାଜୁରିଡାଇନ
Combination of
Decitabine	Nucleoside metabolic inhibitor
Cedazuridine	Cytidine deaminase inhibitor
Clinical data
Trade names	Inqovi
Synonyms	ASTX727, C-DEC
AHFS/Drugs.com	monograph
data	US DailyMed: Cedazuridine_and_decitabine;
Pregnancy; category	AU: X (High risk) ; Not recommended;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; US: ℞-only ;

Decitabine/cedazuridine

Decitabine/cedazuridine

ଡେସିଟାବାଇନ/ସେଡାଜୁରିଡାଇନ (ଇଂରାଜୀ ଭାଷାରେ Decitabine/cedazuridine), ଇନକୋଭି ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ମିଶ୍ରଣ ଯାହା ମାଲୋଡିସପ୍ଲାଷ୍ଟିକ୍ ସିଣ୍ଡ୍ରୋମ (MDS) ଏବଂ କ୍ରୋନିକ୍ ମାୟେଲୋମୋନୋସାଇଟିକ ଲିଉକେମିଆ (CMML) ରୋଗମାନଙ୍କରର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଥକ୍କା, କୋଷ୍ଠକାଠିନ୍ୟ, ରକ୍ତସ୍ରାବ, ମାଂସପେଶୀ ଯନ୍ତ୍ରଣା, ପାଟି ଘା’, ଅଇ, ଅଣନିଶ୍ୱାସ, ରାସ, ଫୁଲା, ନିମୋନିଆ ଏବଂ ଯକୃତ ସମସ୍ୟା ହୋଇପାରେ ।^[୫] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅସ୍ଥି ମଜ୍ଜା ଦମନ ଏବଂ ବନ୍ଧ୍ୟାକରଣ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ । ^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୫] ଡେସିଟାବାଇନ୍ ହେଉଛି ଏକ ନ୍ୟୁକ୍ଲିଓସାଇଡ ମେଟାବୋଲିକ ଇନହିବିଟର ଏବଂ ସେଡାଜୁରିଡାଇନ ହେଉଛି ଏକ ସାଇଟିଡାଇନ ଡିମିନେଜ ପ୍ରତିରୋଧକ ।^[୫]

୨୦୨୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଏବଂ କାନାଡାରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଏହି ମିଶ୍ରଣକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୬] ^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରତି ଚାରି ସପ୍ତାହରେ ଏହାର ଚିକିତ୍ସାର ମୂଲ୍ୟ ପ୍ରାୟ ୭୮୦୦ ଡଲାର ଅଟେ ।^[୮]

ଆଧାର

↑ "Archive copy" (PDF). Archived (PDF) from the original on 13 June 2021. Retrieved 13 June 2021.{{cite web}}: CS1 maint: archived copy as title (link)
↑ "Archive copy" (PDF). Archived (PDF) from the original on 13 June 2021. Retrieved 13 June 2021.{{cite web}}: CS1 maint: archived copy as title (link)
↑ "Archive copy". Archived from the original on 28 August 2021. Retrieved 15 March 2022.{{cite web}}: CS1 maint: archived copy as title (link)
↑ "Inqovi (decitabine and cedazuridine) tablets, for oral use" (PDF). U.S. Food and Drug Administration (FDA). Otsuka Pharmaceutical Co. Archived (PDF) from the original on 8 July 2020. Retrieved 7 July 2020.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ "DailyMed - INQOVI- cedazuridine and decitabine tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 3 December 2021. Retrieved 21 December 2021.
↑ Canada, Health (26 July 2021). "Approved in 2020: Drugs for human use". www.canada.ca. Archived from the original on 22 October 2021. Retrieved 21 December 2021.
↑ "Decitabine and Cedazuridine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 21 December 2021.
↑ "Inqovi Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 21 December 2021.

[1] "Archive copy" (PDF). Archived (PDF) from the original on 13 June 2021. Retrieved 13 June 2021.{{cite web}}: CS1 maint: archived copy as title (link)

[2] "Archive copy" (PDF). Archived (PDF) from the original on 13 June 2021. Retrieved 13 June 2021.{{cite web}}: CS1 maint: archived copy as title (link)

[3] "Archive copy". Archived from the original on 28 August 2021. Retrieved 15 March 2022.{{cite web}}: CS1 maint: archived copy as title (link)

[Inqovi_FDA_label-4] "Inqovi (decitabine and cedazuridine) tablets, for oral use" (PDF). U.S. Food and Drug Administration (FDA). Otsuka Pharmaceutical Co. Archived (PDF) from the original on 8 July 2020. Retrieved 7 July 2020.

[PI2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ "DailyMed - INQOVI- cedazuridine and decitabine tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 3 December 2021. Retrieved 21 December 2021.

[HC2021-6] Canada, Health (26 July 2021). "Approved in 2020: Drugs for human use". www.canada.ca. Archived from the original on 22 October 2021. Retrieved 21 December 2021.

[AHFS2021-7] "Decitabine and Cedazuridine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 21 December 2021.

[8] "Inqovi Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 21 December 2021.

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