ଟୋଲଭାପ୍ଟାନ

ଟୋଲଭାପ୍ଟାନ
Clinical data
Trade names	Samsca, Jinarc, Jynarque, others
Synonyms	OPC-41061
AHFS/Drugs.com	monograph
MedlinePlus	a609033
data	EU EMA: yes; US DailyMed: Tolvaptan;
Pregnancy; category	US: C (Risk not ruled out) ; UK: Contraindicated;
Routes of; administration	By mouth
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	Unknown (40% absorbed)
Protein binding	99%
Metabolism	Liver (CYP3A4-mediated)
Elimination half-life	12 hours (terminal)
Identifiers
	IUPAC name N-(4-{[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide;
ECHA InfoCard	100.219.212
Chemical and physical data
Formula	C26H25ClN2O3
Molar mass	୪୪୮.୯୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ccccc1C(=O)Nc2cc(C)c(cc2)C(=O)N3c4ccc(Cl)cc4[C@H](O)CCC3;
	InChI InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31) ; Key:GYHCTFXIZSNGJT-UHFFFAOYSA-N ;
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ଟୋଲଭାପ୍ଟାନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ସାମସ୍କା, ହେଉଛି ଏକ ଔଷଧ ଯାହା ହୃଦ୍‌ପାତ କିମ୍ବା ଅନୁପଯୁକ୍ତ ଆଣ୍ଟିଡାଇୟୁରେଟିକ ହରମୋନ (SIADH) ସିଣ୍ଡ୍ରୋମ କାରଣରୁ କମ୍ ସୋଡିଅମ ରକ୍ତ‌ତା ଥିଲେ ତାହାର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୮] ଏହା ଅଟୋସୋମାଲ ଡୋମିନାଣ୍ଟ ପଲିସିଷ୍ଟିକ୍ ବୃକ୍‌କ ରୋଗ (ADPKD) ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୁଏ ।^[୯] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୯] ଔଷଧର ପ୍ରଭାବ ୪ ଘଣ୍ଟା ମଧ୍ୟରେ ଆରମ୍ଭ ହୁଏ ।^[୮]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତୃଷା, ଅଇ, ଏବଂ ସୋଡିଅମର ଦ୍ରୁତ ବୃଦ୍ଧି ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ଜଟିଳତା ମଧ୍ୟରେ ଓସମୋଟିକ ଡିମାୟେଲିନେସନ ସିଣ୍ଡ୍ରୋମ, ଯକୃତ ବିଫଳତା ଏବଂ ହାଇପରକାଲେମିଆହୋଇପାରେ ।^[୮] ଏହା ଏକ ଭାସୋପ୍ରେସିନ୍-୨ ରିସେପ୍ଟର _୨ ଆଣ୍ଟାଗୋନିଷ୍ଟ ଯାହା ପରିସ୍ରା ଉତ୍ପାଦନ ବୃଦ୍ଧି କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୧]

୨୦୦୯ରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଟୋଲଭାପ୍ଟାନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୧] ^[୮] ୨୦୨୦ରେ ଏହାର ଏକ ଜେନେରିକ୍ ସଂସ୍କରଣ ଅନୁମୋଦିତ ହୋଇଥିଲା, ଯଦିଓ ୨୦୨୧ ସୁଦ୍ଧା ବ୍ୟବସାୟିକ ଭାବରେ ଉପଲବ୍ଧ ନଥିଲା ।^[୧୦] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୩୦ ମିଗ୍ରାର ୧୦ଟି ବଟିକାର ୨୦୨୧ ସୁଦ୍ଧା ମୂଲ୍ୟ ପ୍ରାୟ ୩,୮୦୦ ଡଲାର ଥିଲା ।^[୧୧] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୭୫୦ ପାଉଣ୍ଡ ।^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Samsca EPAR". European Medicines Agency (EMA). Archived from the original on 6 January 2021. Retrieved 14 December 2020.
↑ "Jinarc EPAR". European Medicines Agency (EMA). Archived from the original on 7 January 2021. Retrieved 14 December 2020.
↑ "Samsca 15 mg tablets - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 24 January 2021. Retrieved 14 December 2020.
↑ "Jinarc 15 mg tablets - Summary of Product Characteristics (SmPC)". (emc). 21 April 2020. Archived from the original on 17 January 2021. Retrieved 14 December 2020.
↑ "Jynarque- tolvaptan kit Jynarque- tolvaptan tablet". DailyMed. 31 March 2020. Archived from the original on 19 October 2020. Retrieved 14 December 2020.
↑ "Samsca- tolvaptan tablet". DailyMed. 26 October 2020. Archived from the original on 18 January 2021. Retrieved 14 December 2020.
↑ Shoaf S, Elizari M, Wang Z, et al. (2005). "Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias". J Cardiovasc Pharmacol Ther. 10 (3): 165–71. doi:10.1177/107424840501000304. PMID 16211205. S2CID 39158242.
↑ ^୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ "Tolvaptan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 August 2019. Retrieved 8 October 2021.
↑ ^୯.୦ ^୯.୧ ^୯.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 706. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Drugs@FDA: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 20 October 2020. Retrieved 15 August 2020.
↑ "Tolvaptan Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 October 2021.

[Samsca_EPAR-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Samsca EPAR". European Medicines Agency (EMA). Archived from the original on 6 January 2021. Retrieved 14 December 2020.

[Jinarc_EPAR-2] "Jinarc EPAR". European Medicines Agency (EMA). Archived from the original on 7 January 2021. Retrieved 14 December 2020.

[3] "Samsca 15 mg tablets - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 24 January 2021. Retrieved 14 December 2020.

[4] "Jinarc 15 mg tablets - Summary of Product Characteristics (SmPC)". (emc). 21 April 2020. Archived from the original on 17 January 2021. Retrieved 14 December 2020.

[5] "Jynarque- tolvaptan kit Jynarque- tolvaptan tablet". DailyMed. 31 March 2020. Archived from the original on 19 October 2020. Retrieved 14 December 2020.

[6] "Samsca- tolvaptan tablet". DailyMed. 26 October 2020. Archived from the original on 18 January 2021. Retrieved 14 December 2020.

[pk-7] Shoaf S, Elizari M, Wang Z, et al. (2005). "Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias". J Cardiovasc Pharmacol Ther. 10 (3): 165–71. doi:10.1177/107424840501000304. PMID 16211205. S2CID 39158242.

[AHFS2021-8] ୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ "Tolvaptan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 August 2019. Retrieved 8 October 2021.

[BNF80-9] ୯.୦ ^୯.୧ ^୯.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 706. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[10] "Drugs@FDA: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 20 October 2020. Retrieved 15 August 2020.

[US2021Price-11] "Tolvaptan Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 October 2021.

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