କ୍ୟାଣ୍ଡେସାର୍ଟାନ

କ୍ୟାଣ୍ଡେସାର୍ଟାନ
Clinical data
Pronunciation	/ˌkændɪˈsɑːrtən/
Trade names	Atacand, others
Synonyms	Candesartan cilexetil
AHFS/Drugs.com	monograph
MedlinePlus	a601033
Pregnancy; category	AU: D ;
Routes of; administration	By mouth
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Bioavailability	15% (candesartan cilexetil)
Metabolism	Candesartan cilexetil: intestinal wall; candesartan: liver (CYP2C9)
Elimination half-life	9 hours
Excretion	Kidney 33%, faecal 67%
Identifiers
	IUPAC name 2-ethoxy-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-1,3-benzodiazole-7-carboxylic acid;
ECHA InfoCard	100.132.654
Chemical and physical data
Formula	C24H20N6O3
Molar mass	୪୪୦.୪୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOc2nc1cccc(C(=O)O)c1n2Cc5ccc(c3ccccc3c4nn[nH]n4)cc5;
	InChI InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29) ; Key:HTQMVQVXFRQIKW-UHFFFAOYSA-N ;
(verify)

କ୍ୟାଣ୍ଡେସାର୍ଟାନ ଏକ ଔଷଧ ଯାହା ଉଚ୍ଚ ରକ୍ତଚାପ, ହୃଦ୍‌ପାତ ଏବଂ ମଧୁମେହ ବୃକ୍‌କ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ଦିଆଯାଏ । ^[୧] ^[୨] ଉଚ୍ଚ ରକ୍ତଚାପରେ ଏହା ଅନେକ ପ୍ରଥମ ଧାଡ଼ିର ଔଷଧ ମଧ୍ୟରୁ ଗୋଟିଏ । ^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ମୁଣ୍ଡ ବୁଲାଇବା, ଥକାପଣ, କାଶ, ଏବଂ ପାକ-ଅନ୍ତନଳୀ ସମସ୍ୟା ହୋଇପାରେ । ^[୪] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଚ୍ଚ ପୋଟାସିୟମ୍, ନିମ୍ନ ରକ୍ତଚାପ ଏବଂ ବୃକ୍‌କ ସମସ୍ୟା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ । ^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୫] ଏହା ଏକ ଆଞ୍ଜିଓଟେନସିନ୍ ୨ ରିସେପ୍ଟର ବ୍ଲକର୍ (ARB) | ^[୬]

୧୯୯୦ ମସିହାରେ କ୍ୟାଣ୍ଡେସାର୍ଟନ ପେଟେଣ୍ଟ୍ ହୋଇଥିଲେ ଏବଂ ୧୯୯୭ରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୭] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୩୨ ମାସିକ ମିଗ୍ରା ଔଷଧର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ 2୨୫ ଡଲାର ଥିଲା । ^[୯] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୨ ପାଉଣ୍ଡ | ^[୧୦]

ଆଧାର

1 2 "DailyMed - CANDESARTAN tablet". dailymed.nlm.nih.gov. Archived from the original on 7 February 2019. Retrieved 29 December 2021.
↑ "Candesartan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 29 December 2021.
1 2 "Candesartan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 29 December 2021.
↑ "Candesartan". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 27 August 2021. Retrieved 29 December 2021.
↑ "Candesartan". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 27 August 2021. Retrieved 29 December 2021.
↑ "DailyMed - CANDESARTAN tablet". dailymed.nlm.nih.gov. Archived from the original on 7 February 2019. Retrieved 29 December 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 471. ISBN 9783527607495. Archived from the original on 2021-10-31. Retrieved 2021-10-24.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 189. ISBN 978-0857114105.
↑ "Candesartan Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 October 2021. Retrieved 29 December 2021.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 189. ISBN 978-0857114105.

[autogen1-1] 1 2 "DailyMed - CANDESARTAN tablet". dailymed.nlm.nih.gov. Archived from the original on 7 February 2019. Retrieved 29 December 2021.

[AHFS2021-2] "Candesartan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 29 December 2021.

[autogen2-3] 1 2 "Candesartan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 29 December 2021.

[Liv2021-4] "Candesartan". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 27 August 2021. Retrieved 29 December 2021.

[autogen3-5] "Candesartan". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 27 August 2021. Retrieved 29 December 2021.

[PI2021-6] "DailyMed - CANDESARTAN tablet". dailymed.nlm.nih.gov. Archived from the original on 7 February 2019. Retrieved 29 December 2021.

[Fis2006-7] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 471. ISBN 9783527607495. Archived from the original on 2021-10-31. Retrieved 2021-10-24.

[BNF81-8] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 189. ISBN 978-0857114105.

[9] "Candesartan Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 October 2021. Retrieved 29 December 2021.

[autogen4-10] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 189. ISBN 978-0857114105.

[୧]

[୨]

[୩]

[୪]

[୫]

[୬]

[୭]

[୮]

[୯]

[୧୦]