ଏସମୋଲୋଲ

ଏସମୋଲୋଲ
Clinical data
AHFS/Drugs.com	monograph
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	Intravenous
Pharmacokinetic data
Bioavailability	-
Protein binding	60%
Metabolism	Erythrocytic
Onset of action	Within a min
Elimination half-life	9 minutes
Duration of action	Up to 30 min
Excretion	Kidney
Identifiers
	IUPAC name methyl (RS)-3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate;
Chemical and physical data
Formula	C16H25NO4
Molar mass	୨୯୫.୩୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC)CCc1ccc(OCC(O)CNC(C)C)cc1;
	InChI InChI=1S/C16H25NO4/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3 ; Key:AQNDDEOPVVGCPG-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Esmolol

ଏସମୋଲୋଲ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ବ୍ରେଭିବ୍ଲକ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ସୁପ୍ରାଭେଣ୍ଟ୍ରିକୁଲାର ଟାକିକାର୍ଡ଼ିଆ, ଉଚ୍ଚ ରକ୍ତଚାପ ଏବଂ ମାୟୋକାର୍ଡିଆଲ ଇସକେମିଆ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୧] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୧] ଔଷଧର ପ୍ରଭାବ ଏକ ମିନିଟ୍ ମଧ୍ୟରେ ଆରମ୍ଭ ହୋଇପାରେ ଏବଂ ୩୦ ମିନିଟ୍ ପର୍ଯ୍ୟନ୍ତ ରହିପାରେ ।^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତଚାପ, ଝାଳ ବୋହିବା, ମୁଣ୍ଡବିନ୍ଧା, ବାନ୍ତି, ଏବଂ ଇଞ୍ଜେକସନ ସ୍ଥାନରେ ପ୍ରଦାହ ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଫୁଲା, ଫୁସଫୁସ ଇଡିମା ଏବଂ ମୂତ୍ର ଧାରଣ ହୋଇପାରେ ।^[୩] ଏହା ଏକ କାର୍ଡିଓସିଲେକ୍ଟିଭ ବିଟା₁ ରିସେପ୍ଟର ବ୍ଲକର୍ ଯାହା ସିମ୍ପାଥେଟିକ ସ୍ନାୟୁ ପ୍ରଣାଳୀକୁ ପ୍ରତିରୋଧ କରିଥାଏ ।^[୪] ^[୫] ଏହା ଦ୍ୱିତୀୟ ଶ୍ରେଣୀର ଏକ ଆଣ୍ଟିଆରିସମିକ୍ ।^[୬]

୧୯୮୦ ମସିହାରେ ଏସମୋଲୋଲ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୮୬ରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୭] ^[୧] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୩] ଯୁକ୍ତରାଜ୍ୟରେ ପ୍ରତି ୧୦୦ ମିଗ୍ରା ଭାଏଲ ପାଇଁ ପ୍ରାୟ ୧୦ ପାଊଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ ।^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୬ ଡଲାର ଥିଲା ।^[୮]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ ^୧.୭ "Esmolol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 23 July 2021.
↑ Benowitz, Neal L. (2020). "11. Antihypertensive agents". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 193. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-12-05.
↑ ^୩.୦ ^୩.୧ ^୩.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 166. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ Barash, Paul G.; Cullen, Bruce F.; Stoelting, Robert K.; Cahalan, Michael; Stock, M. Christine (1 January 2011). Clinical Anesthesia (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. PT1598. ISBN 978-1-4511-2297-8. Archived from the original on 28 August 2021. Retrieved 23 July 2021.
↑ Sharar, Sam R.; Cullen, Bruce F.; Stock, Christine M.; Ortega, Rafael; Holt, Natalie; Nathan, Naveen; Connor, Christopher (9 July 2021). Clinical Anesthesia Fundamentals (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. PT335. ISBN 978-1-9751-1302-5. Archived from the original on 28 August 2021. Retrieved 23 July 2021.
↑ Marx, John; Hockberger, Robert; Walls, Ron (1 August 2013). Rosen's Emergency Medicine - Concepts and Clinical Practice E-Book: 2-Volume Set (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 1038. ISBN 978-1-4557-4987-4. Archived from the original on 28 August 2021. Retrieved 23 July 2021.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 462. ISBN 978-3-527-60749-5. Archived from the original on 2021-06-10. Retrieved 2021-03-18.
↑ "Esmolol Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 August 2021. Retrieved 23 July 2021.

[AHFS2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ ^୧.୭ "Esmolol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 23 July 2021.

[Katzung2021-2] Benowitz, Neal L. (2020). "11. Antihypertensive agents". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 193. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-12-05.

[BNF80-3] ୩.୦ ^୩.୧ ^୩.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 166. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[4] Barash, Paul G.; Cullen, Bruce F.; Stoelting, Robert K.; Cahalan, Michael; Stock, M. Christine (1 January 2011). Clinical Anesthesia (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. PT1598. ISBN 978-1-4511-2297-8. Archived from the original on 28 August 2021. Retrieved 23 July 2021.

[5] Sharar, Sam R.; Cullen, Bruce F.; Stock, Christine M.; Ortega, Rafael; Holt, Natalie; Nathan, Naveen; Connor, Christopher (9 July 2021). Clinical Anesthesia Fundamentals (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. PT335. ISBN 978-1-9751-1302-5. Archived from the original on 28 August 2021. Retrieved 23 July 2021.

[6] Marx, John; Hockberger, Robert; Walls, Ron (1 August 2013). Rosen's Emergency Medicine - Concepts and Clinical Practice E-Book: 2-Volume Set (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 1038. ISBN 978-1-4557-4987-4. Archived from the original on 28 August 2021. Retrieved 23 July 2021.

[7] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 462. ISBN 978-3-527-60749-5. Archived from the original on 2021-06-10. Retrieved 2021-03-18.

[8] "Esmolol Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 August 2021. Retrieved 23 July 2021.

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