ଏଡୋକ୍ସାବାନ

ଏଡୋକ୍ସାବାନ
Clinical data
Trade names	Savaysa, Lixiana, Roteas, others
Synonyms	DU-176b
AHFS/Drugs.com	monograph
MedlinePlus	a614055
data	EU EMA: yes; US DailyMed: Edoxaban;
Pregnancy; category	US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	62%; Tmax 1–2 hours
Protein binding	55%
Metabolism	minimal CES1, CYP3A4/5, hydrolysis, glucuronidation
Elimination half-life	10–14 hours
Excretion	62% feces, 35% urine (97% of 60 mg)
Identifiers
	IUPAC name N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide;
Chemical and physical data
Formula	C24H30ClN7O4S
Molar mass	୫୪୮.୦୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCC2=C(C1)SC(=N2)C(=O)N[C@@H]3C[C@H](CC[C@@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C;
	InChI InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1 ; Key:HGVDHZBSSITLCT-JLJPHGGASA-N ;
(verify)

ଏଡୋକ୍ସାବାନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଲିକ୍ସିଆନା, ହେଉଛି ଏକ ଆଣ୍ଟିକୋଏଗୁଲାଣ୍ଟ (ରକ୍ତ ପତଳା) ଯାହା ରକ୍ତ ଜମାଟ ବାନ୍ଧିବା ପ୍ରତିରୋଧ ଏବଂ ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୬] ପ୍ରୋସ୍ଥେଟିକ୍ ହାର୍ଟ ଭଲଭ୍ ସହିତ ଏହା ସୁରକ୍ଷିତ କି ନାହିଁ ତାହା ସ୍ପଷ୍ଟ ନୁହେଁ ।^[୬] ଏହାକୁ ଦିନକୁ ଥରେ ପାଟିରେ ଦିଆଯାଏ; ଶରୀରର ଓଜନ ଏବଂ ବୃକ୍‌କର କାର୍ଯ୍ୟକ୍ଷମତା ଉପରେ ନିର୍ଭର କରି ୩୦ ମିଗ୍ରା କିମ୍ବା ୬୦ ମିଗ୍ରା ଔଷଧ ଦିଆଯାଏ । ^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନାକରୁ ରକ୍ତସ୍ରାବ, ମୂତ୍ରରେ ରକ୍ତ ଏବଂ ରକ୍ତହୀନତା ହୋଇପାରେ ।^[୭] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ଚର୍ମ ରାସ ଏବଂ ମସ୍ତିଷ୍କ ରକ୍ତସ୍ରାବ ହୋଇପାରେ ।^[୬] ୱାର୍ଫାରିନ୍ ତୁଳନାରେ ଏହାର କମ୍ ପାରସ୍ପରିକ ପ୍ରତିକ୍ରିୟା ଅଛି ।^[୫] ଏହା ଏକ ଡାଇରେକ୍ଟ ଫ୍ୟାକ୍ଟର ଏକ୍ସେ ଇନହିବିଟର ପରିବାରର ଔଷଧ ।^[୬]

ଡାଇଚି ସାଙ୍କିଓ ଏହି ଏଡୋକ୍ସାବାନ ବିକଶିତ କରିଥିଲେ ଏବଂ ୨୦୧୧ ମସିହାରେ ଜାପାନରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ର ଏବଂ ୟୁରୋପରେ ୨୦୧୫ରେ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୭]^[୯] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ଏକ ମାସର ଖର୍ଚ୍ଚ ୨୦୨୧ ମସିହାରେ ୫୦ ପାଉଣ୍ଡ ଥିଲା ଯାହା ୱାରଫାରିନ ମୂଲ୍ୟର ୫୦ ଗୁଣ ଥିଲା ।^[୬] ^[୧୦] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୩୯୦ ଡଲାର ଅଟେ ।^[୧୧]

ଆଧାର

↑ "Edoxaban (Savaysa) Use During Pregnancy". Drugs.com. 17 June 2020. Archived from the original on 18 May 2021. Retrieved 18 May 2021.
↑ "Lixiana EPAR". European Medicines Agency (EMA). Archived from the original on 24 October 2020. Retrieved 23 July 2020.
↑ "Roteas EPAR". European Medicines Agency (EMA). Archived from the original on 25 November 2020. Retrieved 25 September 2020.
↑ "Savaysa- edoxaban tosylate tablet, film coated". DailyMed. 24 April 2020. Archived from the original on 23 July 2020. Retrieved 23 July 2020.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ Parasrampuria DA, Truitt KE (June 2016). "Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral Anticoagulant that Inhibits Clotting FactorXa". Clinical Pharmacokinetics. 55 (6): 641–55. doi:10.1007/s40262-015-0342-7. PMC 4875962. PMID 26620048.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ ^୬.୪ ^୬.୫ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 135-136. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ ^୭.୦ ^୭.୧ "Lixiana 60mg Film-Coated Tablets - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Archived from the original on 5 March 2021. Retrieved 18 May 2021.
↑ "First market approval in Japan for Lixiana (Edoxaban)" (Press release). 2011-04-22. Archived from the original on 2013-11-06.
↑ "Edoxaban Tosylate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2021. Retrieved 14 July 2021.
↑ Hitchings, Andrew; Lonsdale, Dagan; Burrage, Daniel; Baker, Emma (2019). The Top 100 Drugs: Clinical Pharmacology and Practical Prescribing (in ଇଂରାଜୀ) (2nd ed.). Elsevier. pp. 118–119. ISBN 978-0-7020-7442-4. Archived from the original on 2021-05-22. Retrieved 2021-11-09.
↑ "Edoxaban Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 14 July 2021.

[Drugs.com_pregnancy-1] "Edoxaban (Savaysa) Use During Pregnancy". Drugs.com. 17 June 2020. Archived from the original on 18 May 2021. Retrieved 18 May 2021.

[Lixiana_EPAR-2] "Lixiana EPAR". European Medicines Agency (EMA). Archived from the original on 24 October 2020. Retrieved 23 July 2020.

[Roteas_EPAR-3] "Roteas EPAR". European Medicines Agency (EMA). Archived from the original on 25 November 2020. Retrieved 25 September 2020.

[Savaysa_FDA_label-4] "Savaysa- edoxaban tosylate tablet, film coated". DailyMed. 24 April 2020. Archived from the original on 23 July 2020. Retrieved 23 July 2020.

[Dol2016-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ Parasrampuria DA, Truitt KE (June 2016). "Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral Anticoagulant that Inhibits Clotting FactorXa". Clinical Pharmacokinetics. 55 (6): 641–55. doi:10.1007/s40262-015-0342-7. PMC 4875962. PMID 26620048.

[BNF80-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ ^୬.୪ ^୬.୫ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 135-136. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[EMC2020-7] ୭.୦ ^୭.୧ "Lixiana 60mg Film-Coated Tablets - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Archived from the original on 5 March 2021. Retrieved 18 May 2021.

[Dai201-8] "First market approval in Japan for Lixiana (Edoxaban)" (Press release). 2011-04-22. Archived from the original on 2013-11-06.

[AHFS2021-9] "Edoxaban Tosylate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2021. Retrieved 14 July 2021.

[Hit2019-10] Hitchings, Andrew; Lonsdale, Dagan; Burrage, Daniel; Baker, Emma (2019). The Top 100 Drugs: Clinical Pharmacology and Practical Prescribing (in ଇଂରାଜୀ) (2nd ed.). Elsevier. pp. 118–119. ISBN 978-0-7020-7442-4. Archived from the original on 2021-05-22. Retrieved 2021-11-09.

[Gx2021-11] "Edoxaban Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 14 July 2021.

[୧]

[୪]

[୨]

[୩]

[୫]

[୬]

[୭]

[୮]

[୯]

[୧୦]

[୧୧]