ଟ୍ରୋପିସେଟ୍ରନ

ଟ୍ରୋପିସେଟ୍ରନ
Clinical data
Trade names	Navoban, Setrovel, others
Synonyms	ICS 205-930
AHFS/Drugs.com	International Drug Names
Pregnancy; category	AU: B3 ; ;
Routes of; administration	By mouth, IV
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: Not available or approved ;
Pharmacokinetic data
Bioavailability	~60–80%
Protein binding	71%
Metabolism	Liver (CYP3A4, CYP1A2, CYP2D6)
Elimination half-life	6–8 hours
Excretion	Kidney, Fecal
Identifiers
	IUPAC name (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1methyl-indole-3-carboxylate;
Chemical and physical data
Formula	C17H20N2O2
Molar mass	୨୮୪.୩୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN4[C@@H]1CC[C@H]4C[C@H](C1)OC(=O)c3c[nH]c2ccccc23;
	InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+ ; Key:ZNRGQMMCGHDTEI-ITGUQSILSA-N ;
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ଟ୍ରୋପିସେଟ୍ରନ (ଇଂରାଜୀ ଭାଷାରେ Tropisetron) ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବିକ୍ରୟ ନାମ ନାଭୋବାନ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମୁଖ୍ୟତଃ କେମୋଥେରାପି ପ୍ରରୋଚିତ ଅଇ ଏବଂ ବାନ୍ତି ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଅଧିକ ପ୍ରଭାବ ପାଇଁ ଏହା ସ‌ହିତ ଡେକ୍ସାମେଥାଜୋନ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୧] ଉପକାରଗୁଡ଼ିକ ଅନଡାନସେଟ୍ରନ୍ ସହିତ ସମାନ ଅଟେ ।^[୧] ଏହାକୁ ପାଟିରେ କିମ୍ବା ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଇପାରେ ।^[୧]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ଶୁଖିଲା ପାଟି ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ ।^[୨] ^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୪] ଏହା ଏକ ୫-ଏଚଟି<sub id="mwJw">୩</sub> (5-HT <sub id="mwJw">3</sub> ) ରିସେପ୍ଟର ବିରୋଧୀ ଅଟେ ।^[୧]

ଟ୍ରୋପିସେଟ୍ରନ ୧୯୮୨ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୯୨ରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ଓଣ୍ଡାନସେଟ୍ରନର ବିକଳ୍ପ ଭାବରେ ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଜରୁରୀ ଔଷଧ ତାଲିକାରେ ଲିପିବଦ୍ଧ ଅଛି ।^[୬] ଏହା ୟୁରୋପରେ ଉପଲବ୍ଧ କିନ୍ତୁ ଆମେରିକାରେ ନୁହେଁ। ^[୭] ^[୮]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ Simpson, K; Spencer, CM; McClellan, KJ (June 2000). "Tropisetron: an update of its use in the prevention of chemotherapy-induced nausea and vomiting". Drugs. 59 (6): 1297–315. doi:10.2165/00003495-200059060-00008. PMID 10882164.
↑ Aronson, Jeffrey K. (11 April 2014). Meyler's Side Effects of Drugs 15E: The International Encyclopedia of Adverse Drug Reactions and Interactions (in ଇଂରାଜୀ). Newnes. p. 1366. ISBN 978-0-444-51005-1. Archived from the original on 10 September 2023. Retrieved 9 September 2023.
↑ ^୩.୦ ^୩.୧ "Tropisetron Hydrochloride". web.archive.org. MedSafe. 28 September 2007. Archived from the original on 28 September 2007. Retrieved 9 September 2023.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
↑ "TROPISETRON-AFT". NPS MedicineWise (in ଇଂରାଜୀ). 3 August 2015. Archived from the original on 5 November 2022. Retrieved 9 September 2023.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 448. ISBN 9783527607495. Archived from the original on 2023-01-12. Retrieved 2022-05-29.
↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
↑ Lemke, Thomas L.; Williams, David A. (24 January 2012). "Foye's Principles of Medicinal Chemistry" (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. Archived from the original on 10 September 2023. Retrieved 9 September 2023.
↑ Feldman, Liane S.; Delaney, Conor P.; Ljungqvist, Olle; Carli, Francesco (31 August 2015). "The SAGES / ERAS® Society Manual of Enhanced Recovery Programs for Gastrointestinal Surgery" (in ଇଂରାଜୀ). Springer. Archived from the original on 10 September 2023. Retrieved 9 September 2023.

[Sim2000-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ Simpson, K; Spencer, CM; McClellan, KJ (June 2000). "Tropisetron: an update of its use in the prevention of chemotherapy-induced nausea and vomiting". Drugs. 59 (6): 1297–315. doi:10.2165/00003495-200059060-00008. PMID 10882164.

[Aron2014-2] Aronson, Jeffrey K. (11 April 2014). Meyler's Side Effects of Drugs 15E: The International Encyclopedia of Adverse Drug Reactions and Interactions (in ଇଂରାଜୀ). Newnes. p. 1366. ISBN 978-0-444-51005-1. Archived from the original on 10 September 2023. Retrieved 9 September 2023.

[MS2023-3] ୩.୦ ^୩.୧ "Tropisetron Hydrochloride". web.archive.org. MedSafe. 28 September 2007. Archived from the original on 28 September 2007. Retrieved 9 September 2023.{{cite web}}: CS1 maint: bot: original URL status unknown (link)

[4] "TROPISETRON-AFT". NPS MedicineWise (in ଇଂରାଜୀ). 3 August 2015. Archived from the original on 5 November 2022. Retrieved 9 September 2023.

[5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 448. ISBN 9783527607495. Archived from the original on 2023-01-12. Retrieved 2022-05-29.

[WHO22nd-6] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[7] Lemke, Thomas L.; Williams, David A. (24 January 2012). "Foye's Principles of Medicinal Chemistry" (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. Archived from the original on 10 September 2023. Retrieved 9 September 2023.

[8] Feldman, Liane S.; Delaney, Conor P.; Ljungqvist, Olle; Carli, Francesco (31 August 2015). "The SAGES / ERAS® Society Manual of Enhanced Recovery Programs for Gastrointestinal Surgery" (in ଇଂରାଜୀ). Springer. Archived from the original on 10 September 2023. Retrieved 9 September 2023.

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