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ଡେକ୍ସଟ୍ରୋଆମ୍ପେଟାମିନ

ଉଇକିପିଡ଼ିଆ‌ରୁ
ଡେକ୍ସଟ୍ରୋଆମ୍ପେଟାମିନ
Clinical data
Pronunciation/ˌdɛkstroʊæmˈfɛtəmiːn/
Trade namesDexedrine, DextroStat, Metamina, Attentin, Zenzedi, others
SynonymsD-amphetamine, dexamfetamine, dexamphetamine, (S)-amphetamine, (+)-amphetamine, dexamfetamine sulfate
AHFS/Drugs.commonograph
MedlinePlusa605027
data
Pregnancy
category
  • AU: B3
  • US: C (Risk not ruled out)
Dependence
liability		Moderate-high[୧][୨]
Addiction
liability		Moderate-high[୧][୨]
Routes of
administration		By mouth
Legal status
Legal status
Pharmacokinetic data
BioavailabilityBy mouth: 75–100%[୬]
Protein binding15–40%[୭]
MetabolismCYP2D6,[୩] DBH,[୪] FMO3[୫]
Onset of actionIR dosing: 0.5–1.5 hours[୮]
Elimination half-life9–11 hours[୩][୯]
pH-dependent: 7–34 hours[୧୦]
Duration of actionIR dosing: 3–6 hours[୧୧]
XR dosing: 8–12 hours[୨][୧୧]
ExcretionKidney (45%);[୧୨] urinary pH-dependent
Identifiers
  • (2S)-1-Phenylpropan-2-amine
ECHA InfoCard100.000.103 Edit this at Wikidata
Chemical and physical data
FormulaC9H13N
Molar mass୧୩୫.୨୧ g·mol−1
3D model (JSmol)
Density0.913 g/cm3
Boiling point201.5 °C (394.7 °F)
Solubility in water20 mg/mL (20 °C)
  • C[C@@H](Cc1ccccc1)N
  • InChI=InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1 ☒N
  • Key:KWTSXDURSIMDCE-QMMMGPOBSA-N checkY
  (verify)

ଡେକ୍ସଟ୍ରୋଆମ୍ପେଟାମିନ ( ଡି-ଏମ୍ପି ), ଯାହା ଡେକ୍ସାମଫେଟାମାଇନ୍ ଭାବରେ ମଧ୍ୟ ଜଣାଶୁଣା, ଧ୍ୟାନାଭାବ ଓ ଅତିସକ୍ରିୟତା ବିକାର (ADHD) ଏବଂ ନିଦ୍ରାବେଶର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ । [୧୩] ମେଦବହୁଳତା ପାଇଁ ଏହା ସ୍ୱଳ୍ପକାଳୀନ ବ୍ୟବହୃତ ହୋଇଥିବାବେଳେ, ଏପରି ବ୍ୟବହାର ଆଉ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।[୧୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।[୧୩] ଏହା କାର୍ଯ୍ୟ କାର୍ଯ୍ୟ ଦକ୍ଷତା, ଖେକ କୁଦ ପ୍ରଦର୍ଶନ ଏବଂ ସାମରିକ ବାହିନୀଦ୍ୱାରା ଉନ୍ନତ ହେବା ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇଛି । [୧୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପେଟ ଯନ୍ତ୍ରଣା, ଶୋଇବାରେ ଅସୁବିଧା, ଦୃତ ହୃତ୍‌ଗତି, ଉଚ୍ଚ ରକ୍ତଚାପ, ଉଦ୍‌ବେଗ, କମ୍ପନ ଏବଂ ତରଳ ଝାଡ଼ା ଅନ୍ତର୍ଭୁକ୍ତ । [୧୪] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କାର୍ଡିଓମାଇଓପାଥି, ଅପବ୍ୟବହାର, ସାଇକୋସିସ୍, ଆକ୍ରୋଶ ଏବଂ ବାତ ହୋଇପାରେ । [୧୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର ଅପରିପକ୍ୱତା ହୋଇପାରେ ।[୧୪] ଏହା ଏକ କେନ୍ଦ୍ରୀୟ ସ୍ନାୟୁ ପ୍ରଣାଳୀ (CNS) ଉତ୍ତେଜକ ଏବଂ ଆମ୍ଫେଟାମିନର ଆଇସୋମର୍ । [୧୪]

୧୯୩୭ ମସିହାରେ ଡେକ୍ସଟ୍ରୋଆମ୍ପେଟାମିନ ଚିକିତ୍ସା ବ୍ୟବହାରରେ ଆସିଥିଲା ।[୧୬] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । [୧୩] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦ମିଗ୍ରାର ୩୦ଟି ଟାବଲେଟର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ £ ୮୦ ଥିଲା ।[୧୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୬୦ ଡଲାର ଅଟେ। [୧୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ଏକ ଅନୁସୂଚୀତ II ନିୟନ୍ତ୍ରିତ ପଦାର୍ଥ ।[୧୮]

ଆଧାର

[ସମ୍ପାଦନା]
  1. ↑ ୧.୦ ୧.୧ Stahl SM (March 2017). "Amphetamine (D,L)". Prescriber's Guide: Stahl's Essential Psychopharmacology (6th ed.). Cambridge, United Kingdom: Cambridge University Press. pp. 45–51. ISBN 9781108228749. Archived from the original on 8 June 2019. Retrieved 5 August 2017.
  2. ↑ ୨.୦ ୨.୧ ୨.୨ Stahl SM (March 2017). "Amphetamine (D)". Prescriber's Guide: Stahl's Essential Psychopharmacology (6th ed.). Cambridge, United Kingdom: Cambridge University Press. pp. 39–44. ISBN 9781108228749. Retrieved 8 August 2017.
  3. ↑ ୩.୦ ୩.୧ "HIGHLIGHTS OF PRESCRIBING INFORMATION" (PDF). Archived (PDF) from the original on 18 July 2018. Retrieved 28 December 2021.
  4. ↑ Lemke TL, Williams DA, Roche VF, Zito W (2013). Foye's Principles of Medicinal Chemistry (7th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 648. ISBN 978-1609133450. Alternatively, direct oxidation of amphetamine by DA β-hydroxylase can afford norephedrine.
  5. ↑ Krueger, SK; Williams, DE (June 2005). "Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism". Pharmacology & therapeutics. 106 (3): 357–87. doi:10.1016/j.pharmthera.2005.01.001. PMID 15922018.
  6. ↑ "Pharmacology". Dextromphetamine. Archived from the original on 6 August 2019. Retrieved 5 November 2013. {{cite encyclopedia}}: |work= ignored (help)
  7. ↑ "Pharmacology". Amphetamine. University of Alberta. 8 February 2013. Archived from the original on 12 October 2013. Retrieved 5 November 2013. {{cite encyclopedia}}: |work= ignored (help)
  8. ↑ Green-Hernandez, Carol; Singleton, Joanne K.; Aronzon, Daniel Z. (1 January 2001). Primary Care Pediatrics. Lippincott Williams & Wilkins. p. 243. ISBN 9780781720083. Archived from the original on 23 May 2016. Retrieved 8 August 2021.
  9. ↑ "Adderall IR Prescribing Information" (PDF). United States Food and Drug Administration. Teva Pharmaceuticals USA, Inc. October 2015. pp. 1–6. Archived (PDF) from the original on 15 September 2018. Retrieved 18 May 2016.
  10. ↑ "AMPHETAMINE". Archived from the original on 2 October 2017. Retrieved 28 December 2021.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  11. ↑ ୧୧.୦ ୧୧.୧ Mignot EJ (October 2012). "A practical guide to the therapy of narcolepsy and hypersomnia syndromes". Neurotherapeutics. 9 (4): 739–752. doi:10.1007/s13311-012-0150-9. PMC 3480574. PMID 23065655.
  12. ↑ "dextrostat (dextroamphetamine sulfate) tablet [Shire US Inc.]". DailyMed. Wayne, PA: Shire US Inc. August 2006. Archived from the original on 13 January 2012. Retrieved 8 November 2013.
  13. ↑ ୧୩.୦ ୧୩.୧ ୧୩.୨ ୧୩.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 370. ISBN 978-0857114105.
  14. ↑ ୧୪.୦ ୧୪.୧ ୧୪.୨ ୧୪.୩ ୧୪.୪ "Dextroamphetamine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 August 2021. Retrieved 28 December 2021.
  15. ↑ Miller, Richard Lawrence (2002). The Encyclopedia of Addictive Drugs (in ଇଂରାଜୀ). Greenwood Publishing Group. p. 107. ISBN 978-0-313-31807-8. Archived from the original on 11 January 2022. Retrieved 28 December 2021.
  16. ↑ Cutler, Janis; Marcus, Eric (28 April 2010). Psychiatry (in ଇଂରାଜୀ). Oxford University Press. p. 569. ISBN 978-0-19-970682-2. Archived from the original on 11 January 2022. Retrieved 28 December 2021.
  17. ↑ "Dextroamphetamine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 28 December 2021.
  18. ↑ "DailyMed - DEXTROAMPHETAMINE SULFATE tablet". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 28 December 2021.
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