ଟେନୋଫୋଭିର ଆଲାଫେନାମାଇଡ

ଟେନୋଫୋଭିର ଆଲାଫେନାମାଇଡ
Clinical data
Pronunciation	/ˌtəˈnoʊfəvɪər ˌæləˈfɛnəmaɪd/
Trade names	Vemlidy; Genvoya (with elvitegravir, cobicistat and emtricitabine); Odefsey (with emtricitabine and rilpivirine); Descovy (with emtricitabine); Symtuza (with darunavir, cobicistat, and emtricitabine)
Synonyms	GS-7340
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Tenofovir_alafenamide;
Pregnancy; category	AU: B3 ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Protein binding	~80%
Elimination half-life	0.51 hour
Excretion	Feces (31.7%), urine (<1%)
Identifiers
	IUPAC name Isopropyl (2S)-2-[[[(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phenoxy-phosphoryl]amino]propanoate;
Chemical and physical data
Formula	C21H29N6O5P
Molar mass	୪୭୬.୪୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3;
	InChI InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1; Key:LDEKQSIMHVQZJK-CAQYMETFSA-N;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Tenofovir_alafenamide

ଟେନୋଫୋଭିର ଆଲାଫେନାମାଇଡ, ବେପାର ନାମ ଭେନୋଲିଡି, ହେଉଛିଏକ ଔଷଧ ଯାହା ଦୀର୍ଘକାଳୀନ ଯକୃତ ପ୍ରଦାହ ଖ ରୋଗ, ବିଶେଷତଃ କ୍ଷତିପୁର୍ତ୍ତ ଯକୃତ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ଦିଆଯାଏ ।^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୫] ଏହା ୧୧ ବର୍ଷରୁ ଅଧିକ ବୟସର ଲୋକଙ୍କଠାରେ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୨] ଔଷଧ ଦେବା ବନ୍ଦ କରିବା ପରେ ଯକୃତ ପ୍ରଦାହ ଖ ରୋଗ ଖରାପ ଦିଗକୁ ଗତି କରିପାରେ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ବାନ୍ତି, ଏବଂ ଥକାପଣ ହୋଇପାରେ ।^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଲାକ୍ଟିକ ଏସିଡୋସିସ ହୋଇପାରେ ।^[୫] ସାଂଘାତିକ ଯକୃତ ଜନିତ ସମସ୍ୟାରେ ଏହା ଦେବାକୁ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୫] ଟେନୋଫୋଭିର ଆଲାଫେନାମାଇଡ୍ ଶରୀରଦ୍ୱାରା ଟେନୋଫୋଭିର ରୂପାନ୍ତରିତ ହୁଏ, ଯାହାଦ୍ୱାରା ଏହା କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୨] ଏହା ରିଭର୍ସ ଟ୍ରାନ୍ସକ୍ରିପଟେଜକୁ ଅବରୋଧ କରେ ଯାହାଦ୍ୱାରା ଭୂତାଣୁକୁ ବହୁଗୁଣିତ କରିବାରେ ବାଧା ଦିଏ ।^[୨]

ଟେନୋଫୋଭିର ଆଲାଫେନାମାଇଡ ଔଷଧ ୨୦୧୬ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୧୭ରେ ୟୁରୋପରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହାର ଚିକିତ୍ସା ବାବଦ ମାସକୁ ପ୍ରାୟ ୧୩୦୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ରାଶିର ମୂଲ୍ୟ ୩୨୫ ଡଲାର ।^[୭] ^[୮]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Tenofovir alafenamide (Vemlidy) Use During Pregnancy". Drugs.com. 26 December 2018. Archived from the original on 9 July 2021. Retrieved 18 April 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Vemlidy EPAR". European Medicines Agency (EMA). Archived from the original on 13 July 2021. Retrieved 26 January 2021.
↑ "Vemlidy 25 mg film coated tablets - Summary of Product Characteristics (SmPC)". (emc). 8 September 2020. Archived from the original on 11 July 2021. Retrieved 12 November 2020.
↑ ^୪.୦ ^୪.୧ "Vemlidy- tenofovir alafenamide tablet". DailyMed. 11 February 2020. Archived from the original on 9 July 2021. Retrieved 18 April 2020.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ "Tenofovir Alafenamide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 26 September 2021.
↑ "Vemlidy Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 26 September 2021.
↑ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 659. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Pharmacoeconomic Review Report TENOFOVIR ALAFENAMIDE (VEMLIDY)" (PDF). Archived (PDF) from the original on 18 October 2018. Retrieved 26 September 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Tenofovir alafenamide (Vemlidy) Use During Pregnancy". Drugs.com. 26 December 2018. Archived from the original on 9 July 2021. Retrieved 18 April 2020.

[EPAR2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Vemlidy EPAR". European Medicines Agency (EMA). Archived from the original on 13 July 2021. Retrieved 26 January 2021.

[3] "Vemlidy 25 mg film coated tablets - Summary of Product Characteristics (SmPC)". (emc). 8 September 2020. Archived from the original on 11 July 2021. Retrieved 12 November 2020.

[Vemlidy_FDA_label-4] ୪.୦ ^୪.୧ "Vemlidy- tenofovir alafenamide tablet". DailyMed. 11 February 2020. Archived from the original on 9 July 2021. Retrieved 18 April 2020.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ "Tenofovir Alafenamide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 26 September 2021.

[6] "Vemlidy Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 26 September 2021.

[BNF80-7] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 659. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[8] "Pharmacoeconomic Review Report TENOFOVIR ALAFENAMIDE (VEMLIDY)" (PDF). Archived (PDF) from the original on 18 October 2018. Retrieved 26 September 2021.

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