ସୋଡ଼ିଅମ ନାଇଟ୍ରୋପୃସାଇଡ

ସୋଡ଼ିଅମ ନାଇଟ୍ରୋପୃସାଇଡ
	Idealized depiction of this compound (top), and a picture of a sample (bottom).
Clinical data
Trade names	Nipride, Nitropress, others
Synonyms	SNP
AHFS/Drugs.com	monograph
data	US FDA: Nitroprusside;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	intravenous
ATC code	C02DD01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	100% (intravenous)
Metabolism	By haemoglobin being converted to cyanmethaemoglobin and cyanide ions
Onset of action	nearly immediate
Elimination half-life	<2 minutes (3 days for thiocyanate metabolite)
Duration of action	1 to 10 minutes
Excretion	kidney (100%; as thiocyanate)
Identifiers
	IUPAC name disodium pentacyano(nitroso)irondiuide;
CAS Number	13755-38-9;
PubChem CID	11953895;
DrugBank	DB00325;
ChemSpider	21170789;
UNII	EAO03PE1TC;
ChEMBL	CHEMBL136478;
ECHA InfoCard	100.119.126
Chemical and physical data
Formula	C5FeN6Na2O
Molar mass	261.918
3D model (JSmol)	Interactive image;
Density	1.72 g/cm3
Solubility in water	100 mg/mL (20 °C)
	SMILES [Na+].[Na+].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N;
	InChI InChI=1S/5CN.Fe.NO.2Na/c51-2;;1-2;;/q;;;;;2-1;2*+1; Key:FPWUWQVZUNFZQM-UHFFFAOYSA-N;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Sodium_nitroprusside

ସୋଡ଼ିଅମ ନାଇଟ୍ରୋପୃସାଇଡ ବା ଏସଏନପି (ଇଂରାଜୀ ଭାଷାରେ Sodium nitroprusside ବା SNP, ବିକ୍ରୟ ନାମ ନାଇଟ୍ରୋପ୍ରେସ /Nitropress) ଏକ ଔଷଧ ଯାହା ରକ୍ତଚାପ (blood pressure) କମ୍ କରିବାକୁ ଦିଆଯାଏ । ଲକ୍ଷଣ‌ଯୁକ୍ତ ଅତ୍ୟୁଚ୍ଚ ରକ୍ତଚାପ (blood pressure is very high and resulting in symptoms) ଥିଲେ, କେତେକ ହୃଦ୍‌ପାତ ରୋଗରେ ଓ ଅପରେଶନ ସମୟରେ ରକ୍ତସ୍ରାବ (bleeding) କମେଇବା ନିମନ୍ତେ ଏହି ଔଷଧ ଦିଆଯାଏ । ନିରବଛିନ୍ନ ଧୀର ପ୍ରବାହିତ ଶିରାଭ୍ୟନ୍ତର ଇଞ୍ଜେକସନ (continuous injection into a vein) ଆକାରରେ ଏହା ଦିଆଯାଏ । ଏହାର ପ୍ରଭାବ ତୁରନ୍ତ ଆରମ୍ଭ ହୁଏ ଓ ପ୍ରାୟ ୧୦ ମିନିଟ ପର୍ଯ୍ୟନ୍ତ ରହେ ।^[୧]

ସୋଡ଼ିଅମ ନାଇଟ୍ରୋପୃସାଇଡର ସୋଡ଼ିଅମ ନାଇଟ୍ରୋପୃସାଇଡରେ ନିମ୍ନ ରକ୍ତଚାପ (low blood pressure) ଓ ସ୍ୟାନାଇଡ ବିଷକ୍ରିୟା (cyanide toxicity) ହୋଇପାରେ । ମେଥେମୋଗ୍ଲୋବିନେମିଆ (methemoglobinemia) ଭଳି ସାଂଘାତିକ ପ୍ରତିକ୍ରିୟା ମଧ୍ୟ ହୋଇପାରେ ।^[୧] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ସମ୍ଭାବନ ଯୋଗୁ ଏହା ଗର୍ଭାବସ୍ଥାରେ ଦିଆଯାଏନାହିଁ ।^[୨] ଅଧିକ ମାତ୍ରାର ଔଷଧ ୧୦ ମିନିଟରୁ ଅଧିକ ସମୟ ଦିଆଯାଏନାହିଁ ।^[୩] ଏହା ରକ୍ତନଳୀ ସ୍ଫୀତ କରି କାର୍ଯ୍ୟ କରେ ।^[୧]

ସୋଡ଼ିଅମ ନାଇଟ୍ରୋପୃସାଇଡ ସନ ୧୮୫୦ରେ ଆବିଷ୍କୃତ ହୋଇଥିଲା ଓ ସନ ୧୯୨୮ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାରରେ ଲାଗିଲା । ^[୪]^[୫] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ମାସ ଡୋଜର ମୂଲ୍ୟ ୨୫ ଆମେରିକୀୟ ଡଲାରରୁ କମ୍ ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Sodium Nitroprusside". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ "Nitroprusside (Nitropress) Use During Pregnancy". www.drugs.com. Retrieved 14 December 2016.
↑ WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 283. ISBN 9789241547659. Retrieved 8 December 2016.
↑ Friederich, JA; Butterworth, JF 4th (July 1995). "Sodium Nitroprusside: Twenty Years and Counting". Anesthesia and Analgesia. 81 (1): 152–162. doi:10.1213/00000539-199507000-00031. PMID 7598246.{{cite journal}}: CS1 maint: numeric names: authors list (link)
↑ Nichols, David G.; Greeley, William J.; Lappe, Dorothy G.; Ungerleider, Ross M.; Cameron, Duke E.; Spevak, Philip J.; Wetzel, Randall C. (2006). Critical Heart Disease in Infants and Children (in ଇଂରାଜୀ) (2 ed.). Elsevier Health Sciences. p. 192. ISBN 9780323070072.
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 146. ISBN 9781284057560.

[AHFS2016-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Sodium Nitroprusside". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.

[2] "Nitroprusside (Nitropress) Use During Pregnancy". www.drugs.com. Retrieved 14 December 2016.

[WHO2008-3] WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 283. ISBN 9789241547659. Retrieved 8 December 2016.

[Hist1995-4] Friederich, JA; Butterworth, JF 4th (July 1995). "Sodium Nitroprusside: Twenty Years and Counting". Anesthesia and Analgesia. 81 (1): 152–162. doi:10.1213/00000539-199507000-00031. PMID 7598246.{{cite journal}}: CS1 maint: numeric names: authors list (link)

[5] Nichols, David G.; Greeley, William J.; Lappe, Dorothy G.; Ungerleider, Ross M.; Cameron, Duke E.; Spevak, Philip J.; Wetzel, Randall C. (2006). Critical Heart Disease in Infants and Children (in ଇଂରାଜୀ) (2 ed.). Elsevier Health Sciences. p. 192. ISBN 9780323070072.

[WHO19th-6] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[Ric2015-7] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 146. ISBN 9781284057560.

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