ପେଗାପ୍ଟାନିବ

Pegaptanib sodium
Clinical data
Trade names	Macugen
AHFS/Drugs.com	monograph
MedlinePlus	a607057
Pregnancy; category	US: B (No risk in non-human studies) ;
Routes of; administration	Intravitreal injection
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Elimination half-life	10 days
Identifiers
	IUPAC name RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT), 5'-ester with α,α'-[4,12-dioxo-6[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)], sodium salt;
Chemical and physical data
Formula	C294H342F13N107Na28O188P28[C2H4O](m+n) (m+n≈900)
Molar mass	~50 kg/mol
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Pegaptanib

ପେଗାପ୍ଟାନିବ (ଇଂରାଜୀ ଭାଷାରେ Pegaptanib), ମାକୁଗେନ ଏହାର ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଓଦା ବୟସ ସମ୍ବନ୍ଧୀୟ ମାକୁଲାର ଡିଜେରେସନ (AMD)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୋଇଥିଲା ।^[୨] ଏହା ଆଖିରେ ଇଞ୍ଜେକସନ ଆକାରରେ ବ୍ୟବହୃତ ହେଉଥିଲା ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅସ୍ପଷ୍ଟ ଦୃଷ୍ଟିଶକ୍ତି, ମୋତିଆବିନ୍ଦୁ, କଞ୍ଜକ୍ଟିଭାଲ ରକ୍ତସ୍ରାବ, ଆଖି ଯନ୍ତ୍ରଣା ଏବଂ ଆଖି ଭିତର ବା ଇଣ୍ଟ୍ରାଓକୁଲାର ଚାପ ବଢ଼ିଥାଏ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲାକସିସ ଏବଂ ଏଣ୍ଡୋଫଥାଲମାଇଟିସ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ | ^[୩] ଏହା ଭାସ୍କୁଲାର ଏଣ୍ଡୋଥେଲିଆଲ ଅଭିବୃଦ୍ଧି କାରକକୁ (VEGF) ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୩]

୨୦୦୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ପେଗାପ୍ଟାନିବ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ୨୦୦୬ରେ ଏହା ୟୁରୋପରେ ଅନୁମୋଦିତ ହୋଇଥିବାବେଳେ ପରବର୍ତ୍ତୀ ସମୟରେ ଏହି ଅନୁମୋଦନ ପ୍ରତ୍ୟାହାର କରାଯାଇଥିଲା ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୦.୩ ମିଗ୍ରା ଭିଆଲର ମୂଲ୍ୟ ପ୍ରାୟ ୭୮୦ ଡଲାର ।^[୬] ୨୦୧୬ ସୁଦ୍ଧା ଏହା ଆଉ ଆମେରିକାରେ ଉପଲବ୍ଧ ନୁହେଁ । ^[୭]

ଆଧାର

↑ Drug Information: Pegaptanib Sodium Injection Archived 2013-12-14 at the Wayback Machine.
1 2 "Macugen (pegaptanib)" (PDF). European Medicines Agency: 1–3. 2010. Archived from the original (PDF) on 2013-12-13. Retrieved 2013-12-08.
1 2 3 "Pegaptanib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 June 2021. Retrieved 26 October 2021.
↑ "MACUGEN- pegaptanib sodium injection, solution". dailymed.nlm.nih.gov. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
↑ "Macugen". Archived from the original on 6 May 2021. Retrieved 26 October 2021.
↑ "Macugen Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 September 2020. Retrieved 26 October 2021.
↑ Wong, Randall (2016). "Ocular drug delivery systems" (PDF). Retina Today. Archived (PDF) from the original on 26 October 2021. Retrieved 26 October 2021.

[1] Drug Information: Pegaptanib Sodium Injection Archived 2013-12-14 at the Wayback Machine.

[EMA2010-2] 1 2 "Macugen (pegaptanib)" (PDF). European Medicines Agency: 1–3. 2010. Archived from the original (PDF) on 2013-12-13. Retrieved 2013-12-08.

[AHFS2021-3] 1 2 3 "Pegaptanib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 June 2021. Retrieved 26 October 2021.

[PI2021-4] "MACUGEN- pegaptanib sodium injection, solution". dailymed.nlm.nih.gov. Archived from the original on 26 October 2021. Retrieved 26 October 2021.

[5] "Macugen". Archived from the original on 6 May 2021. Retrieved 26 October 2021.

[6] "Macugen Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 September 2020. Retrieved 26 October 2021.

[7] Wong, Randall (2016). "Ocular drug delivery systems" (PDF). Retina Today. Archived (PDF) from the original on 26 October 2021. Retrieved 26 October 2021.

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