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ନୁସିନରସେନ

ଉଇକିପିଡ଼ିଆ‌ରୁ
(Nusinersenରୁ ଲେଉଟି ଆସିଛି)
ନୁସିନରସେନ
Clinical data
Trade namesSpinraza
SynonymsIONIS-SMNRx, ISIS-SMNRx
AHFS/Drugs.commonograph
MedlinePlusa617010
data
Pregnancy
category
  • AU: B1
  • US: N (Not classified yet)
Routes of
administration
Intrathecal
Legal status
Legal status
Pharmacokinetic data
Bioavailability100% (intrathecal)
Protein binding<25% (in CSF), >94% (in plasma)[]
MetabolismExonuclease (3’- and 5’)-mediated hydrolysis
Elimination half-life135–177 days (in CSF), 63–87 days (in plasma)
Identifiers
  • all-P-ambo-2’-O-(2-Methoxyethyl)-5-methyl-P-thiouridylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3’→5’)-2’-O-(2-methoxyethyl)-P-thioadenylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3’→5’)-2’-O-(2-methoxyethyl)-P-thioadenylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(3’→5’)-2’-O-(2-methoxyethyl)-P-thioadenylyl-(3’→5’)-2’-O-(2-methoxyethyl)-P-thioadenylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(3’→5’)-2’-O-(2-methoxyethyl)-P-thioguanylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3’→5’)-2’-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(3’→5’)-2’-O-(2-methoxyethyl)-P-thioguanylyl-(3’→5’)-2’-O-(2-methoxyethyl)guanosine[]
Chemical and physical data
FormulaC234H323N61Na17O128P17S17[]
Molar mass୭,୫୦୦.୮୬ g·mol−1
3D model (JSmol)
  • Cc1cn(c(=O)[nH]c1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)OP(=S)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cc(c(nc4=O)N)C)OCCOC)OP(=S)(O)OC[C@@H]5[C@H]([C@H]([C@@H](O5)n6cnc7c6ncnc7N)OCCOC)OP(=S)(O)OC[C@@H]8[C@H]([C@H]([C@@H](O8)n9cc(c(nc9=O)N)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cc(c(=O)[nH]c1=O)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cc(c(=O)[nH]c1=O)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cc(c(=O)[nH]c1=O)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cc(c(nc1=O)N)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cnc2c1ncnc2N)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cc(c(=O)[nH]c1=O)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cnc2c1ncnc2N)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cnc2c1ncnc2N)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cc(c(=O)[nH]c1=O)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cnc2c1nc([nH]c2=O)N)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cc(c(nc1=O)N)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cc(c(=O)[nH]c1=O)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cnc2c1nc([nH]c2=O)N)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cnc2c1nc([nH]c2=O)N)OCCOC)O)OCCOC

ନୁସିନରସେନ, ଏକ ବେପାର ନାମ ସ୍ପିନରାଜା, ହେଉଛି ମେରୁଦଣ୍ଡୀୟ ମାଂସପେଶୀ ଆଟ୍ରୋଫି (SMA)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।[] ଏହା ମୋଟର କାର୍ଯ୍ୟକୁ ଉନ୍ନତ କରିଥାଏ ।[] ଏହା ମେରୁଦଣ୍ଡ କେନାଲରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ ।[]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶ୍ୱାସକ୍ରିୟା ସଂକ୍ରମଣ, କୋଷ୍ଠକାଠିନ୍ୟ ଏବଂ କାନ ସଂକ୍ରମଣ ହୋଇପାରେ ।[] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କମ ପ୍ଲାଟେଲେଟ୍, ରକ୍ତସ୍ରାବ ଏବଂ ବୃକ୍‌କ ସମସ୍ୟା ହୋଇପାରେ ।[] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।[] ଏହା ଏକ ଆଣ୍ଟିସେନ୍ସ ଓଲିଗୋନ୍ୟୁକ୍ଲିଓଟାଇଡ଼ ଯାହା ମୋଟୋର ନିଉରନ ବୃଦ୍ଧି କରେଇଥାଏ ।[]

୨୦୧୬ ମସିହାରେ ଆମେରିକାରେ ଏବଂ ୨୦୧୭ରେ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ନୁସିନରସେନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।[] [] ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାତ୍ରାର ମୂଲ୍ୟ ୨୦୨୧ ମସିହାର ୭୫,୦୦୦ ପାଉଣ୍ଡ ଥିଲେ ।[] ଯୁକ୍ତରାଷ୍ଟରେ ଏହାର ମୂଲ୍ୟ ପ୍ରାୟ ୧୩୩,୦୦୦ ଡଲାର ଅଟେ ।[]

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