ଇଭାବ୍ରାଡାଇନ

ଇଭାବ୍ରାଡାଇନ
Clinical data
Pronunciation	/ɪˈvæbrədiːn/
Trade names	Corlanor, Procoralan
Synonyms	Ivabradine hydrochloride, S-16257
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Ivabradine;
Routes of; administration	By mouth
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	40%
Protein binding	70%
Metabolism	Liver (first-pass) >50%, CYP3A4-mediated
Elimination half-life	2 hours
Excretion	Kidney and fecal
Identifiers
	IUPAC name 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one;
Chemical and physical data
Formula	C27H36N2O5
Molar mass	୪୬୮.୫୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(CCc1cc(OC)c(OC)cc1C2)CCCN(C[C@@H]4c3cc(OC)c(OC)cc3C4)C;
	InChI InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1 ; Key:ACRHBAYQBXXRTO-OAQYLSRUSA-N ;
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ଇଭାବ୍ରାଡାଇନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବିକ୍ରୟ ନାମ ପ୍ରୋକୋରାଲାନ, ଏକ ଔଷଧ ଯାହା ଦୀର୍ଘସ୍ଥାୟୀ ସ୍ଥିର ଆଞ୍ଜାଇନା ଯନ୍ତ୍ରଣା ଏବଂ ହୃଦ୍‌ପାତ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଯେତେବେଳେ ହୃତ୍‌ପିଣ୍ଡ ଗତି ପ୍ରତି ମିନିଟରେ ଅତି କମରେ ୭୦ ସ୍ପନ୍ଦନ ହୋଇଥାଏ ଏବଂ ବିଟା ବ୍ଲକର୍ଦ୍ୱାରା ଅବସ୍ଥା ସମ୍ପୂର୍ଣ୍ଣ ଭାବରେ ପରିଚାଳିତ ହୋଇପାରିନଥାଏ, ସେତେବେଳେ ଏହି ଔଷଧ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୧] ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସାମୟିକ ଭାବରେ ଉଜ୍ଜ୍ୱଳ ଦେଖାଯାଏ ଏବଂ ଧୀର ହୃତ୍‌ପିଣ୍ଡ ଗତି ହୁଏ ।^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଟ୍ରିଆଲ୍ ଫିବ୍ରିଲେସନ୍ ଏବଂ ଆଞ୍ଜିଓଇଡିମା ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୩] ଏହା ସାଇନସ୍ ନୋଡରେ ଆଇ<a href="./ପେସମେକର୍_କରେଣ୍ଟ୍_%7C" rel="mw:WikiLink" data-linkid="193" data-cx="{"adapted":false,"sourceTitle":{"title":"Pacemaker current","description":"Electric current in the heart","pageprops":{"wikibase_item":"Q1747705"},"pagelanguage":"en"},"targetFrom":"mt"}" class="cx-link" id="mwHQ" title="ପେସମେକର୍ କରେଣ୍ଟ୍ |"><sub id="mwHg">ଏଫ</sub></a> ତରଙ୍ଗକୁ (I<sub id="mwHg">f</sub> କରେଣ୍ଟକୁ) ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ଯାହାଦ୍ୱାରା ହୃତ୍ ସ୍ପନ୍ଦନ ହାର ହ୍ରାସ ହୋଇଥାଏ ।^[୧]

୨୦୦୫ ମସିହାରେ ୟୁରୋପରେ ଏବଂ ୨୦୧୫ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ଇଭାବ୍ରାଡାଇନ ବ୍ୟବହାର ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୧] ^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୪]^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ୪ ସପ୍ତାହ ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ £୫ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୪୫୦ ଡଲାର ଅଟେ ।^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Procoralan". Archived from the original on 10 November 2021. Retrieved 1 December 2021.
↑ Yancy, CW; Jessup, M; Bozkurt, B; Butler, J; Casey, DE Jr; Colvin, MM; Drazner, MH; Filippatos, G; Fonarow, GC (20 May 2016). "2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America". Circulation. 134 (13): e282–e293. doi:10.1161/CIR.0000000000000435. PMID 27208050.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Ivabradine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 26 November 2021.
↑ ^୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 227. ISBN 978-0857114105.
↑ Research, Center for Drug Evaluation and (10 February 2022). "2021 First Generic Drug Approvals". FDA (in ଇଂରାଜୀ). Archived from the original on 21 June 2022. Retrieved 22 October 2022.
↑ "Ivabradine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 1 December 2021.

[EPAR2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Procoralan". Archived from the original on 10 November 2021. Retrieved 1 December 2021.

[Van2016-2] Yancy, CW; Jessup, M; Bozkurt, B; Butler, J; Casey, DE Jr; Colvin, MM; Drazner, MH; Filippatos, G; Fonarow, GC (20 May 2016). "2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America". Circulation. 134 (13): e282–e293. doi:10.1161/CIR.0000000000000435. PMID 27208050.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Ivabradine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 26 November 2021.

[BNF81-4] ୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 227. ISBN 978-0857114105.

[5] Research, Center for Drug Evaluation and (10 February 2022). "2021 First Generic Drug Approvals". FDA (in ଇଂରାଜୀ). Archived from the original on 21 June 2022. Retrieved 22 October 2022.

[6] "Ivabradine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 1 December 2021.

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