ସୋରାଫେନିବ

ସୋରାଫେନିବ
Clinical data
Trade names	Nexavar, others
Synonyms	Nexavar; Sorafenib tosylate
AHFS/Drugs.com	monograph
MedlinePlus	a607051
data	EU EMA: yes; US DailyMed: Sorafenib;
Pregnancy; category	AU: D ; US: D (Evidence of risk) ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	38–49%
Protein binding	99.5%
Metabolism	Liver oxidation and glucuronidation (CYP3A4 & UGT1A9-mediated)
Elimination half-life	25–48 hours
Excretion	Faeces (77%) and urine (19%)
Identifiers
	IUPAC name 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]; phenoxy]-N-methyl-pyridine-2-carboxamide;
ECHA InfoCard	100.110.083
Chemical and physical data
Formula	C21H16ClF3N4O3
Molar mass	୪୬୪.୮୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl;
	InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) ; Key:MLDQJTXFUGDVEO-UHFFFAOYSA-N ;
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ସୋରାଫେନିବ, ଏକ ବିକ୍ରୟ ନାମ ନେକ୍ସାଭର, ହେଉଛି ଏକ ଔଷଧ ଯାହା ବୃକ୍‌କୀୟ ଜୀବକୋଷ କର୍କଟ, ହେପାଟୋସେଲ୍ୟୁଲାର କର୍କଟ ଏବଂ କେତେକ ପ୍ରକାରର ଥାଇରଏଡ କର୍କଟ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଲ ଝାଡ଼ା, ରାସ, କେଶହାନୀ, ସଂକ୍ରମଣ ଏବଂ ଥକାପଣ ହୋଇପାରେ ।^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହୃଦ୍‌ଘାତ, ଜଠରାନ୍ତ୍ର ଛିଦ୍ର, ଯକୃତ ସମସ୍ୟା, ରକ୍ତସ୍ରାବ ଏବଂ ଉଚ୍ଚ ରକ୍ତଚାପ ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ କିମ୍ବା ସ୍ତନ୍ୟପାନ କରାଇବା ସମୟରେ ଏହା ଦେଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୩] ଏହା ଏକ ପ୍ରୋଟିନ କାଇନେଜ ଇନହିବିଟର ଶ୍ରେଣୀର ଔଷଧ ।^[୨]

୨୦୦୫ ମସିହାରେ ଆମେରିକାରେ ଏବଂ ୨୦୦୬ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ଚିକିତ୍ସା ପାଇଁ ସୋରାଫେନିବ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୧]^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ୪ ସପ୍ତାହ ଔଷଧ ଖର୍ଚ୍ଚ ୨୦୨୧ ମସିହାରେ ପ୍ରାୟ ୩୬୦୦ ପାଉଣ୍ଡ ଥିଲା ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୨୦,୨୦୦ ଡଲାର ଅଟେ ।^[୫]

ଆଧାର

1 2 "SORAfenib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 14 October 2021.
1 2 3 4 5 6 "Nexavar". Archived from the original on 14 October 2021. Retrieved 14 October 2021.
↑ "Sorafenib (Nexavar) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 14 October 2021.
↑ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1056. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Nexavar Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 14 October 2021.

[AHFS2021-1] 1 2 "SORAfenib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 14 October 2021.

[EPAR2021-2] 1 2 3 4 5 6 "Nexavar". Archived from the original on 14 October 2021. Retrieved 14 October 2021.

[Preg2021-3] "Sorafenib (Nexavar) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 14 October 2021.

[BNF80-4] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1056. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[5] "Nexavar Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 14 October 2021.

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