ସୋଡିୟମ୍ ନାଇଟ୍ରାଇଟ (ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର)

Sodium nitrite
The nitrite anion (space-filling model)	The sodium cation
	; Unit cell of sodium nitrite under standard conditions.
Identifiers
CAS number	7632-00-0
PubChem	23668193
ChemSpider	22689
UNII	M0KG633D4F
UN number	1500 3287
KEGG	D05865
ChEBI	CHEBI:78870
ChEMBL	CHEMBL93268
RTECS number	RA1225000
Jmol-3D images	Image 1
	SMILES N(=O)[O-].[Na+] ;
	InChI InChI=1S/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1 ; Key: LPXPTNMVRIOKMN-UHFFFAOYSA-M InChI=1/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1; Key: LPXPTNMVRIOKMN-REWHXWOFAO;
Properties
Molecular formula	NaNO2
Molar mass	68.9953 g/mol
Appearance	white or slightly yellowish solid
Density	2.168 g/cm3
Melting point	271 °C (520 °F; 544 K)
Solubility in water	71.4 g/100 mL (0 °C) ; 84.8 g/100 mL (25 °C) ; 160 g/100 mL (100 °C)
Solubility	soluble in methanol (4.4 g/100 mL) ; ethanol ; slightly soluble in diethyl ether (0.3 g/100 mL) ; very soluble in ammonia
Acidity (pKa)	~9
Magnetic susceptibility (χ)	−14.5·10−6 cm3/mol
Refractive index (nD)	1.65
Structure
Crystal structure	orthorhombic
Space group	Im2m
Lattice constant	a = 3.5653(8) Å, b = 5.5728(7) Å, c = 5.3846(13) Å
Formula units (Z)	2
Thermochemistry
Std molar; entropy (So298)	106 J/mol K
Std enthalpy of; formation (ΔfHo298)	−359 kJ/mol
Gibbs free energy (ΔfG˚)	−295 kJ/mol
Pharmacology
ATC code	V03AB08 (WHO)
Hazards
GHS pictograms	ଛାଞ୍ଚ:GHS03ଛାଞ୍ଚ:GHS06ଛାଞ୍ଚ:GHS09
GHS signal word	Danger
GHS hazard statements	H272, H301, H319, H400
GHS precautionary statements	P220, P273, P301+310, P305+351+338
NFPA 704	0 3 1 OX
Autoignition; temperature
	Lethal dose or concentration (LD, LC):
Related compounds
Other anions	Sodium nitrate
Other cations	Potassium nitrite; Ammonium nitrite; Lithium nitrite
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references

ଛାଞ୍ଚ:Chembox EINECS

ସୋଡିୟମ୍ ନାଇଟ୍ରାଇଟ ଏକ ଔଷଧ ରୂପରେ ସାଇନାଇଡ ବିଷକ୍ରିୟାର ଚିକିତ୍ସା ପାଇଁ ସୋଡିୟମ୍ ଥାୟୋସଲଫେଟ୍ ସହିତ ବ୍ୟବହୃତ ହୁଏ । ^[୩] ଗମ୍ଭୀର ପରିସ୍ଥିତିର ସାଇନାଇଡ ବିଷକ୍ରିୟାରେ ଏହା କେବଳ ଦିଆଯାଏ । ^[୪] ଯେଉଁମାନଙ୍କ ମଧ୍ୟରେ ଉଭୟ ସିଆନାଇଡ୍ ବିଷାକ୍ତତା ଏବଂ କାର୍ବନ ମନୋକ୍ସାଇଡ୍ ବିଷାକ୍ତ ସୋଡିୟମ୍ ଥିଓସୁଲଫେଟ୍ ସାଧାରଣତ। ପରାମର୍ଶ ଦିଆଯାଏ ।^[୫] ଏହା ଶିରାଭ୍ୟନ୍ତରରେ ଧୀର ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ | ^[୬]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତଚାପ, ମୁଣ୍ଡବିନ୍ଧା, ଅଣନିଶ୍ୱାସ, ଚେତନା ହରେଇବା ଏବଂ ବାନ୍ତି ହୋଇପାରେ ।^[୩] ଅନ୍ତର୍ନିହିତ ହୃଦ ରୋଗରେ ଆକ୍ରାନ୍ତ ବ୍ୟକ୍ତିଙ୍କ ପ୍ରତି ଅଧିକ ଯତ୍ନବାନ ହେବା ଉଚିତ୍ । ^[୬] ଚିକିତ୍ସା ସମୟରେ ଲୋକଙ୍କ ମେଥେମୋଗ୍ଲୋବିନ ସ୍ତର ନିୟମିତ ଯାଞ୍ଚ କରାଯିବା ଉଚିତ। ^[୬] ଗର୍ଭାବସ୍ଥାରେ ଭଲ ଅଧ୍ୟୟନ କରାଯାଇନଥିଲେ ମଧ୍ୟ ଶିଶୁର ସମ୍ଭାବ୍ୟ କ୍ଷତିର କିଛି ପ୍ରମାଣ ଅଛି | ^[୭] ସୋଡିୟମ୍ ନାଇଟ୍ରାଇଟ୍ ମିଥେମୋଗ୍ଲୋବିନ ସୃଷ୍ଟି କରି ସିଆନାଇଡ୍ ସହିତ ବାନ୍ଧିହୋଇଯାଏ ଓ ତାହାକୁ ମାଇଟୋକଣ୍ଡ୍ରିଆରୁ ବାହାର କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ | ^[୮]

୧୯୨୦ ଏବଂ ୧୯୩୦ ଦଶକରେ ସୋଡିୟମ ନାଇଟ୍ରାଇଟ୍ ଚିକିତ୍ସା ବ୍ୟବହାରରେ ଆସିଥିଲା ।^[୯] ^[୧୦] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ତାଲିକାରେ ଏହାର ନାମ ଅଛି ।^[୧୧] ସୋଡିୟମ୍ ଥାୟୋସଲଫେଟ ସହିତ ଏହାର ମୂଲ୍ୟ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ପ୍ରାୟ ୧୧୦ ଡଲାର୍ | ^[୧୨]

ଆଧାର[ସମ୍ପାଦନା]

↑ T. Gohda; M. Ichikawa (November 1996). "The Refinement of the Structure of Ferroelectric Sodium Nitrite". Journal of the Korean Physical Society. 29: 551–554.
↑ Zumdahl, Steven S. (2009). Chemical Principles (6th ed.). Houghton Mifflin Company. p. A23. ISBN 978-0-618-94690-7.
↑ ^୩.୦ ^୩.୧ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 65. hdl:10665/44053. ISBN 9789241547659.
↑ "Sodium Nitrite Solution for Injection - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. Archived from the original on 18 September 2017. Retrieved 15 January 2017.
↑ Baren, Jill M. (2008). Pediatric Emergency Medicine (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 1018. ISBN 978-1416000877. Archived from the original on 2017-01-16.
↑ ^୬.୦ ^୬.୧ ^୬.୨ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 65. hdl:10665/44053. ISBN 9789241547659.
↑ "Sodium Nitrite Injection - FDA prescribing information, side effects and uses". www.drugs.com. Archived from the original on 2017-01-18.
↑ "Sodium Nitrite Injection - FDA prescribing information, side effects and uses". www.drugs.com. Archived from the original on 2017-01-18.
↑ Dart, Richard C. (2004). Medical Toxicology (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 172. ISBN 9780781728454. Archived from the original on 2017-01-16.
↑ Bryan, Nathan S.; Loscalzo, Joseph (2011). Nitrite and Nitrate in Human Health and Disease (in ଇଂରାଜୀ). Springer Science & Business Media. p. 226. ISBN 9781607616160. Archived from the original on 2017-01-16.
↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
↑ Gasco, L; Rosbolt, MB; Bebarta, VS (April 2013). "Insufficient stocking of cyanide antidotes in US hospitals that provide emergency care". Journal of Pharmacology & Pharmacotherapeutics. 4 (2): 95–102. doi:10.4103/0976-500x.110875. PMC 3669589. PMID 23761707.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1] T. Gohda; M. Ichikawa (November 1996). "The Refinement of the Structure of Ferroelectric Sodium Nitrite". Journal of the Korean Physical Society. 29: 551–554.

[b1-2] Zumdahl, Steven S. (2009). Chemical Principles (6th ed.). Houghton Mifflin Company. p. A23. ISBN 978-0-618-94690-7.

[WHO2008-3] ୩.୦ ^୩.୧ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 65. hdl:10665/44053. ISBN 9789241547659.

[UK2017-4] "Sodium Nitrite Solution for Injection - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. Archived from the original on 18 September 2017. Retrieved 15 January 2017.

[5] Baren, Jill M. (2008). Pediatric Emergency Medicine (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 1018. ISBN 978-1416000877. Archived from the original on 2017-01-16.

[autogen1-6] ୬.୦ ^୬.୧ ^୬.୨ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 65. hdl:10665/44053. ISBN 9789241547659.

[Pro2017-7] "Sodium Nitrite Injection - FDA prescribing information, side effects and uses". www.drugs.com. Archived from the original on 2017-01-18.

[autogen3-8] "Sodium Nitrite Injection - FDA prescribing information, side effects and uses". www.drugs.com. Archived from the original on 2017-01-18.

[9] Dart, Richard C. (2004). Medical Toxicology (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 172. ISBN 9780781728454. Archived from the original on 2017-01-16.

[10] Bryan, Nathan S.; Loscalzo, Joseph (2011). Nitrite and Nitrate in Human Health and Disease (in ଇଂରାଜୀ). Springer Science & Business Media. p. 226. ISBN 9781607616160. Archived from the original on 2017-01-16.

[WHO21st-11] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[12] Gasco, L; Rosbolt, MB; Bebarta, VS (April 2013). "Insufficient stocking of cyanide antidotes in US hospitals that provide emergency care". Journal of Pharmacology & Pharmacotherapeutics. 4 (2): 95–102. doi:10.4103/0976-500x.110875. PMC 3669589. PMID 23761707.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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