ସେର୍ଟ୍ରାଲିନ

ସେର୍ଟ୍ରାଲିନ
Clinical data
Trade names	Zoloft and others
AHFS/Drugs.com	monograph
MedlinePlus	a697048
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth (tablets and solution)
Drug class	Selective serotonin reuptake inhibitor
ATC code	N06AB06 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	44%
Protein binding	98.5%
Metabolism	Hepatic (N-demethylation mainly by CYP2B6)
Elimination half-life	~23–26 h (66 h [less-active metabolite, norsertraline])
Excretion	Renal
Identifiers
	IUPAC name (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;
CAS Number	79617-96-2 ;
PubChem CID	68617;
IUPHAR/BPS	4798;
DrugBank	DB01104 ;
ChemSpider	61881 ;
UNII	QUC7NX6WMB;
KEGG	D02360 ;
ChEBI	CHEBI:9123 ;
ChEMBL	CHEMBL809 ;
Chemical and physical data
Formula	C17H17Cl2N
Molar mass	306.229 g/mol
3D model (JSmol)	Interactive image;
	SMILES ClC1=CC=C([C@H]2C3=C([C@H](CC2)NC)C=CC=C3)C=C1Cl;
	InChI InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1 ; Key:VGKDLMBJGBXTGI-SJCJKPOMSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Sertraline

ସେର୍ଟ୍ରାଲିନ (ଇଂରାଜୀ ଭାଷାରେ Sertraline, ଏକ ବିକ୍ରୟ ନାମ ଜୋଲୋଫ୍ଟ/ Zoloft) ଏକ ସେରୋଟୋନିନ ଆଣ୍ଟାଗୋନିସ୍ଟ ଓ ରିଅପଟେକ ଇନ‌ହିବିଟର (selective serotonin reuptake inhibitor)/ SSRI) ଶ୍ରେଣୀର ଅବସାଦରୋଧୀ (antidepressant) ଔଷଧ ।^[୫] ମୂଖ୍ୟତଃ ଏହା ପ୍ରମୁଖ ଅବସାଦ ବେମାରୀ, ଅବସେସିଭ-କମ୍ପଲସିଭ ଡିଜଅର୍ଡ଼ର, ପ୍ୟାନିକ ଡିଜ‌ଅର୍ଡ଼ର ଓ ସାମାଜିକ ଉତ୍କଣ୍ଠା ବେମାରୀ (social anxiety disorder) ଆଦି ରୋଗରେ ବ୍ୟବ‌ହୃତ ହୁଏ ।^[୫] ଅନ୍ୟାନ୍ୟ ଅବସାଦରୋଧୀ ଔଷଧ ଭଳି ଏହା ପ୍ରଭାବଶାଳୀ ଅଟେ । ^[୫] ସେଟ୍ରାଲିନକୁ ପାଟିରେ ଦିଆଯାଏ । ^[୫]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ଯୌନ ସମସ୍ୟା (sexual dysfunction) ଓ ନିଦ୍ରା ସମସ୍ୟା (troubles with sleep) ଦେଖାଯାଏ । ^[୫] ସାଂଘାତିକ ପ୍ରତିକ୍ରିୟା ହେଲେ ୨୫ ବର୍ଷ ବୟସ୍କ ଲୋକର ଆତ୍ମହତ୍ୟା ସଙ୍କଟ ରହେ ବା ସେରୋଟୋନିନ ସିଣ୍ଡ୍ରୋମ (serotonin syndrome) ହୋଇପାରେ ।^[୫] It is unclear whether use during ଗର୍ଭାବସ୍ଥା ଓ ସ୍ତନ୍ୟ ପାନ (breastfeeding) ସମୟରେ ଏହାର ନିରାପତ୍ତା ସ୍ପଷ୍ଟ ନୁହେଁ । ^[୬] ମାଓ ନିହିବିଟର (MAO inhibitor) ଔଷଧ ସ‌ହିତ ଏହା ବ୍ୟବ‌ହାର କରାଯାଏନାହିଁଁ ।^[୫] ମସ୍ତିଷ୍କ ଉପରେ ଅଧିକ ସେରୋଟୋନିନ (serotonin) ପ୍ରାଭାବ ପକେଇ ସେର୍ଟ୍ରାଲିନ କାମ କରୁଥିବା ବିଶ୍ୱାସ କରାଯାଏ । ^[୫]

ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସନ ୧୯୯୧ରେ ପ୍ରଥମରୁ ବିକ୍ରୟ କରୁଥିବା ଫାଇଜର (Pfizer) କମ୍ପାନୀର ସେର୍ଟ୍ରାଲିନ ଔଷଧ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୫] ଅଧୁନା ଏହା ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହେଉଛି ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସନ ୨୦୧୮ରେ ଏହାର ଏକ ମାସ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୧.୫୦ ଆମେରିକୀୟ ଡଲାର ଅଛି ।^[୭] ସନ ୨୦୧୬ରେ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାର ସର୍ବାଧିକ ମାନସିକ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥଲା,^[୮] ଓ ସନ ୨୦୧୩ରେ ଏହି ପ୍ରେସକ୍ରିପସନ ସଂଖ୍ୟା ପ୍ରାୟ ୪୧ ନିୟୁତ ଥିଲା ।^[୯]

ଆଧାର

↑ "Sertraline". Drugs.com. Retrieved 11 May 2015.
↑ Obach RS, Cox LM, Tremaine LM (February 2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metabolism and Disposition. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID 15547048.
↑ Sertraline FDA Label Last updated May 2014
↑ Brunton L, Chabner B, Knollman B. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Twelfth Edition. McGraw Hill Professional; 2010.
↑ ^୫.୦୦ ^୫.୦୧ ^୫.୦୨ ^୫.୦୩ ^୫.୦୪ ^୫.୦୫ ^୫.୦୬ ^୫.୦୭ ^୫.୦୮ ^୫.୦୯ "Sertraline Hydrochloride". Drugs.com. The American Society of Health-System Pharmacists. Retrieved 8 January 2018.
↑ "Sertraline (Zoloft) Use During Pregnancy". Drugs.com. Retrieved 7 January 2018.
↑ "NADAC as of 2018-01-03". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-06-24. Retrieved 7 January 2018.
↑ Grohol, John M. (12 October 2017). "Top 25 Psychiatric Medications for 2016". Psych Central. Retrieved October 22, 2018.
↑ Grohol, John M. (2014). "Top 25 Psychiatric Medication Prescriptions for 2013". Psych Central. Archived from the original on 31 March 2015. Retrieved 3 April 2015. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

ବାହ୍ୟ ଲିଙ୍କ

[Brand2015-1] "Sertraline". Drugs.com. Retrieved 11 May 2015.

[pmid15547048-2] Obach RS, Cox LM, Tremaine LM (February 2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metabolism and Disposition. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID 15547048.

[FDALabel-3] Sertraline FDA Label Last updated May 2014

[GG-4] Brunton L, Chabner B, Knollman B. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Twelfth Edition. McGraw Hill Professional; 2010.

[AHFS2018-5] ୫.୦୦ ^୫.୦୧ ^୫.୦୨ ^୫.୦୩ ^୫.୦୪ ^୫.୦୫ ^୫.୦୬ ^୫.୦୭ ^୫.୦୮ ^୫.୦୯ "Sertraline Hydrochloride". Drugs.com. The American Society of Health-System Pharmacists. Retrieved 8 January 2018.

[6] "Sertraline (Zoloft) Use During Pregnancy". Drugs.com. Retrieved 7 January 2018.

[7] "NADAC as of 2018-01-03". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-06-24. Retrieved 7 January 2018.

[PsychCentral2-8] Grohol, John M. (12 October 2017). "Top 25 Psychiatric Medications for 2016". Psych Central. Retrieved October 22, 2018.

[9] Grohol, John M. (2014). "Top 25 Psychiatric Medication Prescriptions for 2013". Psych Central. Archived from the original on 31 March 2015. Retrieved 3 April 2015. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

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