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ସିମେଟିଡାଇନ

ଉଇକିପିଡ଼ିଆ‌ରୁ
ସିମେଟିଡାଇନ
Clinical data
Pronunciation/sɪˈmɛtɪdiːn/ or /saɪˈmɛtɪdiːn/
Trade namesTagamet, others[୨]
SynonymsSKF-92334[୩]
AHFS/Drugs.commonograph
MedlinePlusa682256
data
Pregnancy
category
  • AU: B1
  • US: B (No risk in non-human studies)
Routes of
administration		By mouth, intramuscular injection, intravenous infusion[୧]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only (although 200 mg is OTC)
Pharmacokinetic data
Bioavailability60–70%[୫][୪]
Protein binding13–25%[୪][୬]
MetabolismLiver[୪]
Metabolites• Cimetidine sulfoxide[୪]
• Hydroxycimetidine[୪]
• Guanyl urea cimetidine[୪]
Onset of action30 minutes[୭]
Elimination half-life123 minutes (~2 hours)[୬]
Duration of action4–8 hours[୧]
ExcretionUrine[୬]
Identifiers
  • 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
ECHA InfoCard100.052.012 Edit this at Wikidata
Chemical and physical data
FormulaC10H16N6S
Molar mass୨୫୨.୩୪ g·mol−1
3D model (JSmol)
  • CC1=C(N=CN1)CSCCNC(=NC)NC#N
  • InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) checkY
  • Key:AQIXAKUUQRKLND-UHFFFAOYSA-N checkY
  (verify)

ସିମେଟିଡାଇନ, ଏକ ବିକ୍ରୟ ନାମ ଟ୍ୟାଗାମେଟ, ହେଉଛି ଏକ ପ୍ରକାର ଔଷଧ ଯାହା ଅମ୍ଳରୋଗ, ଗ୍ୟାଷ୍ଟ୍ରୋଏସୋଫେଜିଆଲ ରିଫ୍ଲକ୍ସ ରୋଗ (GERD), ବୁକୁଜ୍ୱାଳା, ଏବଂ ଉପର ଅନ୍ତନଳୀର ରକ୍ତସ୍ରାବ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ନିମନ୍ତେ ବ୍ୟବହୃତ ହୁଏ ।[୮] [୯] ଏହା ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇପାରେ ।[୯] ଏହା ପାଟିରେ କିମ୍ବା ଇଞ୍ଜେକ୍ସନଦ୍ୱାରା ଦିଆଯାଏ । [୯] ଏହାର ପ୍ରଭାବ ଏକ ଘଣ୍ଟା ମଧ୍ୟରେ ଆରମ୍ଭ ହୋଇ ୫ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ ।[୧୦]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡ ବୁଲାଇବା, ମୁଣ୍ଡବିନ୍ଧା, ନିଦ୍ରାଳୁ ଏବଂ ତରଳ ଝାଡ଼ା ହୋଇପାରେ ।[୯] ଦୀର୍ଘ ସମୟ ବ୍ୟବହାର ହେଲେ ସ୍ତନ ଆକାର ବୃଦ୍ଧି ହୋଇପାରେ ।[୯] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅନିୟମିତ ହୃତ୍ ସ୍ପନ୍ଦନ, ନିମୋନିଆ ଏବଂ ଦ୍ୱନ୍ଦ୍ୱ ହୋଇପାରେ । [୯] ଗର୍ଭାବସ୍ଥାରେ କ୍ଷତିର କୌଣସି ପ୍ରମାଣ ନାହିଁ, କିନ୍ତୁ ଏହିପରି ବ୍ୟବହାର ଭଲ ଭାବରେ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ ।[୧୧] ଏହା ଏକ ଏଚ<sub id="mwRA">୨</sub> ରିସେପ୍ଟର ଆଣ୍ଟାଗୋନିଷ୍ଟ ଔଷଧ ଯାହା ପାକସ୍ଥଳୀରୁ ଅମ୍ଳ ଉତ୍ପାଦନକୁ ପ୍ରତିବନ୍ଧିତ କରେ ।[୨]

ସିମେଟିଡାଇନ ୧୯୭୧ ମସିହାରେ ବିକଶିତ ହୋଇଥିଲା ଏବଂ ୧୯୭୭ରେ ବ୍ୟବସାୟିକ ବ୍ୟବହାର ନିମନ୍ତେ ଆସିଥିଲା ।[୧୨] [୧୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । [୮] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ମସିହାରେ ଏକ ମାସର ଔଷଧ ମୂଲ୍ୟ £16 ଥିଲା ।[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୩୩ ଡଲାର ଥିଲା ।[୧୪]

  1. ↑ ୧.୦ ୧.୧ Anita Gupta; Nina Singh-Radcliff (12 March 2013). Pharmacology in Anesthesia Practice. Oxford University Press. pp. 177–. ISBN 978-0-19-934399-7. Archived from the original on 2 November 2021. Retrieved 4 October 2021.
  2. ↑ ୨.୦ ୨.୧ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 234–. ISBN 978-3-88763-075-1. Archived from the original on 2020-07-29. Retrieved 2021-10-04.
  3. ↑ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Bibliographies. Springer. pp. 275–. ISBN 978-1-4757-2085-3. Archived from the original on 29 July 2020. Retrieved 4 October 2021.
  4. ↑ ୪.୦ ୪.୧ ୪.୨ ୪.୩ ୪.୪ ୪.୫ Jerrold B. Leikin; Frank P. Paloucek (1995). Poisoning & Toxicology Handbook, 1995-1996. Lexi-Comp, Incorporated. p. 184. ISBN 978-0-916589-08-0. Archived from the original on 2021-11-02. Retrieved 2021-10-04.
  5. ↑ Frank J. Dowd; Bart Johnson; Angelo Mariotti (3 September 2016). Pharmacology and Therapeutics for Dentistry - E-Book. Elsevier Health Sciences. pp. 406–. ISBN 978-0-323-44595-5. Archived from the original on 2 November 2021. Retrieved 4 October 2021.
  6. ↑ ୬.୦ ୬.୧ ୬.୨ Profiles of Drug Substances, Excipients and Related Methodology. Academic Press. 24 October 1984. pp. 176–. ISBN 978-0-08-086108-1. Archived from the original on 2 November 2021. Retrieved 4 October 2021.
  7. ↑ Vallerand AH, Sanoski CA, Deglin JH (25 May 2016). Davis's Drug Guide for Nurses. F.A. Davis. pp. 636–. ISBN 978-0-8036-5779-3.
  8. ↑ ୮.୦ ୮.୧ ୮.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 80. ISBN 978-0857114105.
  9. ↑ ୯.୦ ୯.୧ ୯.୨ ୯.୩ ୯.୪ ୯.୫ "Cimetidine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 November 2021. Retrieved 5 January 2022.
  10. ↑ RN, Linda Lane Lilley, PhD; PharmD, Shelly Rainforth Collins; RN-BC, Julie S. Snyder, MSN (15 December 2015). Pharmacology and the Nursing Process (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 806. ISBN 978-0-323-35828-6. Archived from the original on 11 January 2022. Retrieved 5 January 2022.{{cite book}}: CS1 maint: multiple names: authors list (link)
  11. ↑ "Cimetidine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 December 2020. Retrieved 5 January 2022.
  12. ↑ Fischer, Janos; Ganellin, C. Robin (24 August 2010). Analogue-based Drug Discovery II. John Wiley & Sons. p. 4. ISBN 978-3-527-63212-1. Archived from the original on 29 July 2020. Retrieved 4 October 2021. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  13. ↑ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 444. ISBN 9783527607495. Archived from the original on 2020-07-29. Retrieved 2021-10-04.
  14. ↑ "Cimetidine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 December 2021. Retrieved 5 January 2022.
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