ଲିକ୍ସିସେନାଟାଇଡ

ଲିକ୍ସିସେନାଟାଇଡ
Clinical data
Trade names	Lyxumia (EU), Adlyxin (US)
AHFS/Drugs.com	monograph
MedlinePlus	a617005
data	EU EMA: yes; US DailyMed: Lixisenatide;
Pregnancy; category	AU: B3 ; US: N (Not classified yet) ;
Routes of; administration	Subcutaneous
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Identifiers
ECHA InfoCard	100.210.612
Chemical and physical data
Formula	C215H347N61O65S
Molar mass	୪,୮୫୮.୫୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]c2c1cccc2)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC(CO)C(=O)NCC(=O)NC(C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)N)NC(=O)C(Cc6ccccc6)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(Cc7ccccc7)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(Cc8cnc[nH]8)N;
	InChI InChI=1S/C215H347N61O65S/c1-16-115(10)173(210(337)256-141(68-74-170(299)300)194(321)261-148(94-122-98-232-126-50-24-23-49-124(122)126)199(326)258-143(89-111(2)3)196(323)247-134(58-32-40-83-223)189(316)262-149(96-160(226)285)180(307)235-100-161(286)233-104-165(290)274-85-42-60-156(274)207(334)267-154(108-280)206(333)265-151(105-277)181(308)237-101-162(287)239-117(12)213(340)276-87-44-62-158(276)214(341)275-86-43-61-157(275)208(335)268-153(107-279)204(331)249-132(56-30-38-81-221)187(314)246-131(55-29-37-80-220)186(313)245-130(54-28-36-79-219)185(312)244-129(53-27-35-78-218)184(311)243-128(52-26-34-77-217)183(310)242-127(176(227)303)51-25-33-76-216)272-201(328)146(92-120-45-19-17-20-46-120)260-197(324)144(90-112(4)5)257-190(317)135(59-41-84-231-215(228)229)255-209(336)172(114(8)9)271-177(304)116(11)240-182(309)138(65-71-167(293)294)251-192(319)139(66-72-168(295)296)252-193(320)140(67-73-169(297)298)253-195(322)142(75-88-342-15)254-191(318)137(63-69-159(225)284)250-188(315)133(57-31-39-82-222)248-203(330)152(106-278)266-198(325)145(91-113(6)7)259-200(327)150(97-171(301)302)263-205(332)155(109-281)269-212(339)175(119(14)283)273-202(329)147(93-121-47-21-18-22-48-121)264-211(338)174(118(13)282)270-164(289)103-236-179(306)136(64-70-166(291)292)241-163(288)102-234-178(305)125(224)95-123-99-230-110-238-123/h17-24,45-50,98-99,110-119,125,127-158,172-175,232,277-283H,16,25-44,51-97,100-109,216-224H2,1-15H3,(H2,225,284)(H2,226,285)(H2,227,303)(H,230,238)(H,233,286)(H,234,305)(H,235,307)(H,236,306)(H,237,308)(H,239,287)(H,240,309)(H,241,288)(H,242,310)(H,243,311)(H,244,312)(H,245,313)(H,246,314)(H,247,323)(H,248,330)(H,249,331)(H,250,315)(H,251,319)(H,252,320)(H,253,322)(H,254,318)(H,255,336)(H,256,337)(H,257,317)(H,258,326)(H,259,327)(H,260,324)(H,261,321)(H,262,316)(H,263,332)(H,264,338)(H,265,333)(H,266,325)(H,267,334)(H,268,335)(H,269,339)(H,270,289)(H,271,304)(H,272,328)(H,273,329)(H,291,292)(H,293,294)(H,295,296)(H,297,298)(H,299,300)(H,301,302)(H4,228,229,231)/t115-,116-,117-,118+,119+,125-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,172-,173-,174-,175-/m0/s1; Key:XVVOERDUTLJJHN-IAEQDCLQSA-N;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Lixisenatide

ଲିକ୍ସିସେନାଟାଇଡ, ଲିକ୍ସୁମିଆ ଏବଂ ଆଡଲିକ୍ସିନ ଏହାର ବିକ୍ରୟ ନାମ, ହେଉଛି, ଟାଇପ୍-୨ ମଧୁମେହର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୧] ଏହା ସ‌ହିତ ଅନ୍ୟାନ୍ୟ ଔଷଧ, ଉପ‌ଯୁକ୍ତ ଖାଦ୍ୟ ଏବଂ ବ୍ୟାୟାମ ବ୍ୟବହୃତ ହୁଏ ଯେତେବେଳେ ଏଗୁଡ଼ିକ ପର୍ଯ୍ୟାପ୍ତ ନୁହେଁ ।^[୧] ଚର୍ମ ତଳେ ଇଞ୍ଜେକସନ ଆକାରରେ ଏହା ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ତରଳ ଝାଡ଼ା ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ଅନ୍ତର୍ଭୁକ୍ତ | ^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତ ଶର୍କରା ଏବଂ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କରିବାକୁ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୩] ଏହା ଏକ ଜିଏଲପି-୧ ରିସେପ୍ଟର ଆଗୋନିଷ୍ଟ (GLP-1 ରିସେପ୍ଟର ଆଗୋନିଷ୍ଟ) ଯାହା ଅଗ୍ନାଶୟରୁ ଇନସୁଲିନ୍ ଉତ୍ପାଦନ ବୃଦ୍ଧି କରିଥାଏ ।^[୨] ^[୧]

୨୦୧୩ ମସିହାରେ ୟୁରୋପରେ ଏବଂ ୨୦୧୬ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ଲିକ୍ସିସେନାଟାଇଡ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୧] ^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହି ଔଷଧର ଏକ ମାସର ଖର୍ଚ୍ଚ ମୂଲ୍ୟ ୫୮ ପାଉଣ୍ଡ ଥିଲା । ^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୬୬୦ ଡଲାର ଅଟେ ।^[୪] ଇନସୁଲିନ୍ ଗ୍ଲାର୍ଜିନ୍ ସହିତ ଏହି ଔଷଧର ଏକ ମିଶ୍ରଣ ଉପଲବ୍ଧ ହୁଏ ।^[୩]

ଆଧାର

1 2 3 4 5 6 "Lyxumia". Archived from the original on 11 November 2020. Retrieved 23 November 2021.
1 2 3 "Lixisenatide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 January 2021. Retrieved 23 November 2021.
1 2 3 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 740. ISBN 978-0857114105.
↑ "Lixisenatide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 April 2020. Retrieved 24 November 2021.

[EPAR2021-1] 1 2 3 4 5 6 "Lyxumia". Archived from the original on 11 November 2020. Retrieved 23 November 2021.

[AHFS2021-2] 1 2 3 "Lixisenatide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 January 2021. Retrieved 23 November 2021.

[BNF81-3] 1 2 3 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 740. ISBN 978-0857114105.

[4] "Lixisenatide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 April 2020. Retrieved 24 November 2021.

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